Conservation of metabolic regulation by phosphorylation and non-covalent small-molecule interactions

Here, we review extant observations of protein phosphorylation and small-molecule interactions in metabolism and ask which of their specific regulatory functions are conserved in Escherichia coli and Homo sapiens. While the number of phosphosites is dramatically higher in humans, the number of metab...

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Veröffentlicht in:	Cell systems 2021-06, Vol.12 (6), p.538-546
Hauptverfasser:	Gruber, Christoph H., Diether, Maren, Sauer, Uwe
Format:	Artikel
Sprache:	eng
Schlagworte:	metabolism post-translational regulation protein phosphorylation protein-metabolite interactions systems biology
Online-Zugang:	Volltext
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