A rare case of high-grade intraductal carcinoma of the upper lip: immunohistochemical and genetic analyses
Although intraductal carcinoma (IDC) of the salivary glands was previously called low-grade cribriform cystadenocarcinoma, it was newly categorized in the 4th version of the World Health Organization classification. We report a case of IDC of the upper lip and examined it immunohistochemically and g...
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| Veröffentlicht in: | Medical molecular morphology 2021-09, Vol.54 (3), p.281-288 |
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| creator | Kusafuka, Kimihide Ito, Ichiro Hirata, Kazuki Miyamoto, Kazuya Shimizu, Takeshi Satomi, Hidetoshi Inagaki, Hiroshi Suzuki, Makoto |
| description | Although intraductal carcinoma (IDC) of the salivary glands was previously called low-grade cribriform cystadenocarcinoma, it was newly categorized in the 4th version of the World Health Organization classification. We report a case of IDC of the upper lip and examined it immunohistochemically and genetically. The patient was a 48-year-old Japanese female, who noticed a tiny nodule on her left upper lip. Histologically, the tumor cells, which had eosinophilic cytoplasm, exhibited papillary and solid growth patterns, and regions of suspected microinvasion or intraductal spread were also seen at the periphery of the tumor. Small necrotic foci were noted. Immunohistochemically, the tumor cells were diffusely positive for the androgen receptor, CK19, CK5/6, EGFR, and SOX10, whereas they were focally positive for GCDFP-15, S-100 protein, and mammaglobin. The tumor nests were surrounded by alpha-smooth muscle actin-p63-/calponin-/CK14-positive myoepithelial cells. The Ki-67 labeling index was 51.2%. Genetic analysis showed no evidence of the
TRIM27-RET
or
NCOA4-RET
fusion gene. We finally diagnosed the tumor as a high-grade mixed intercalated duct/apocrine-type IDC of the upper lip. IDC of the minor salivary glands is exceedingly rare. We discuss diagnostic problems associated with minor salivary gland lesions, and the “basal-like” phenotype of this case. |
| doi_str_mv | 10.1007/s00795-021-00291-9 |
| format | Article |
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TRIM27-RET
or
NCOA4-RET
fusion gene. We finally diagnosed the tumor as a high-grade mixed intercalated duct/apocrine-type IDC of the upper lip. IDC of the minor salivary glands is exceedingly rare. We discuss diagnostic problems associated with minor salivary gland lesions, and the “basal-like” phenotype of this case.</description><identifier>ISSN: 1860-1480</identifier><identifier>EISSN: 1860-1499</identifier><identifier>DOI: 10.1007/s00795-021-00291-9</identifier><identifier>PMID: 34009452</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Actin ; Anatomy ; Androgen receptors ; Asians ; Biomarkers, Tumor - analysis ; Calponin ; Carcinoma, Intraductal, Noninfiltrating - diagnosis ; Carcinoma, Intraductal, Noninfiltrating - metabolism ; Carcinoma, Intraductal, Noninfiltrating - surgery ; Case Report ; Case reports ; Cytoplasm ; ErbB Receptors - analysis ; ErbB Receptors - genetics ; Exocrine glands ; Female ; Fusion protein ; Gene Expression Regulation, Neoplastic ; Genetic analysis ; Growth patterns ; Humans ; Immunohistochemistry ; Japan ; Keratin-19 - analysis ; Keratin-19 - genetics ; Keratin-5 - analysis ; Keratin-5 - genetics ; Keratin-6 - analysis ; Keratin-6 - genetics ; Leukocytes (eosinophilic) ; Lip ; Lip - surgery ; Lip Neoplasms - diagnosis ; Lip Neoplasms - metabolism ; Lip Neoplasms - surgery ; Medicine ; Medicine & Public Health ; Middle Aged ; Molecular Medicine ; Nodules ; Pathology ; Phenotypes ; Receptors, Androgen - analysis ; Receptors, Androgen - genetics ; S100 protein ; Salivary gland ; Smooth muscle ; Sox10 protein ; SOXE Transcription Factors - analysis ; SOXE Transcription Factors - genetics ; Tumor cells</subject><ispartof>Medical molecular morphology, 2021-09, Vol.54 (3), p.281-288</ispartof><rights>The Japanese Society for Clinical Molecular Morphology 2021</rights><rights>2021. The Japanese Society for Clinical Molecular Morphology.</rights><rights>The Japanese Society for Clinical Molecular Morphology 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-eba040bf6777f2456c82823caf0fa056fda3db1d205c5f2ed7504036798b8bff3</citedby><cites>FETCH-LOGICAL-c399t-eba040bf6777f2456c82823caf0fa056fda3db1d205c5f2ed7504036798b8bff3</cites><orcidid>0000-0001-5315-2540</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00795-021-00291-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00795-021-00291-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34009452$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kusafuka, Kimihide</creatorcontrib><creatorcontrib>Ito, Ichiro</creatorcontrib><creatorcontrib>Hirata, Kazuki</creatorcontrib><creatorcontrib>Miyamoto, Kazuya</creatorcontrib><creatorcontrib>Shimizu, Takeshi</creatorcontrib><creatorcontrib>Satomi, Hidetoshi</creatorcontrib><creatorcontrib>Inagaki, Hiroshi</creatorcontrib><creatorcontrib>Suzuki, Makoto</creatorcontrib><title>A rare case of high-grade intraductal carcinoma of the upper lip: immunohistochemical and genetic analyses</title><title>Medical molecular morphology</title><addtitle>Med Mol Morphol</addtitle><addtitle>Med Mol Morphol</addtitle><description>Although intraductal carcinoma (IDC) of the salivary glands was previously called low-grade cribriform cystadenocarcinoma, it was newly categorized in the 4th version of the World Health Organization classification. We report a case of IDC of the upper lip and examined it immunohistochemically and genetically. The patient was a 48-year-old Japanese female, who noticed a tiny nodule on her left upper lip. Histologically, the tumor cells, which had eosinophilic cytoplasm, exhibited papillary and solid growth patterns, and regions of suspected microinvasion or intraductal spread were also seen at the periphery of the tumor. Small necrotic foci were noted. Immunohistochemically, the tumor cells were diffusely positive for the androgen receptor, CK19, CK5/6, EGFR, and SOX10, whereas they were focally positive for GCDFP-15, S-100 protein, and mammaglobin. The tumor nests were surrounded by alpha-smooth muscle actin-p63-/calponin-/CK14-positive myoepithelial cells. The Ki-67 labeling index was 51.2%. Genetic analysis showed no evidence of the
TRIM27-RET
or
NCOA4-RET
fusion gene. We finally diagnosed the tumor as a high-grade mixed intercalated duct/apocrine-type IDC of the upper lip. IDC of the minor salivary glands is exceedingly rare. We discuss diagnostic problems associated with minor salivary gland lesions, and the “basal-like” phenotype of this case.</description><subject>Actin</subject><subject>Anatomy</subject><subject>Androgen receptors</subject><subject>Asians</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Calponin</subject><subject>Carcinoma, Intraductal, Noninfiltrating - diagnosis</subject><subject>Carcinoma, Intraductal, Noninfiltrating - metabolism</subject><subject>Carcinoma, Intraductal, Noninfiltrating - surgery</subject><subject>Case Report</subject><subject>Case reports</subject><subject>Cytoplasm</subject><subject>ErbB Receptors - analysis</subject><subject>ErbB Receptors - genetics</subject><subject>Exocrine glands</subject><subject>Female</subject><subject>Fusion protein</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Genetic analysis</subject><subject>Growth patterns</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Japan</subject><subject>Keratin-19 - analysis</subject><subject>Keratin-19 - genetics</subject><subject>Keratin-5 - analysis</subject><subject>Keratin-5 - genetics</subject><subject>Keratin-6 - analysis</subject><subject>Keratin-6 - genetics</subject><subject>Leukocytes (eosinophilic)</subject><subject>Lip</subject><subject>Lip - surgery</subject><subject>Lip Neoplasms - diagnosis</subject><subject>Lip Neoplasms - metabolism</subject><subject>Lip Neoplasms - surgery</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Molecular Medicine</subject><subject>Nodules</subject><subject>Pathology</subject><subject>Phenotypes</subject><subject>Receptors, Androgen - analysis</subject><subject>Receptors, Androgen - genetics</subject><subject>S100 protein</subject><subject>Salivary gland</subject><subject>Smooth muscle</subject><subject>Sox10 protein</subject><subject>SOXE Transcription Factors - analysis</subject><subject>SOXE Transcription Factors - genetics</subject><subject>Tumor cells</subject><issn>1860-1480</issn><issn>1860-1499</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kT1P7TAMhiMEAi7wBxhQJBaWgpM0bcOGENx7JSQWmKM0dU5z1C-SduDfk8PhQ2JgsS358WvLLyGnDC4ZQHkVU1AyA84yAK5YpnbIIasKyFiu1O5XXcEB-RPjGkCUBZf75EDkACqX_JCsb2gwAak1EenoaOtXbbYKpkHqhznlxc6mS-1g_TD2ZsPMLdJlmjDQzk_X1Pf9Moytj_NoW-y9TbwZGrrCAWdvU22614jxmOw500U8-chH5Pn-7un2X_bw-Pf_7c1DZoVSc4a1gRxqV5Rl6XguC1vxigtrHDgDsnCNEU3NGg7SSsexKWXiRVGqqq5q58QRudjqTmF8WTDOuvfRYteZAcclai55paCQKk_o-Q90PS4h3buhZMWghEIkim8pG8YYAzo9Bd-b8KoZ6I0TeuuETk7odye0SkNnH9JL3WPzNfL5-gSILRBTa1hh-N79i-wbLbWUAA</recordid><startdate>20210901</startdate><enddate>20210901</enddate><creator>Kusafuka, Kimihide</creator><creator>Ito, Ichiro</creator><creator>Hirata, Kazuki</creator><creator>Miyamoto, Kazuya</creator><creator>Shimizu, Takeshi</creator><creator>Satomi, Hidetoshi</creator><creator>Inagaki, Hiroshi</creator><creator>Suzuki, Makoto</creator><general>Springer Singapore</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5315-2540</orcidid></search><sort><creationdate>20210901</creationdate><title>A rare case of high-grade intraductal carcinoma of the upper lip: immunohistochemical and genetic analyses</title><author>Kusafuka, Kimihide ; Ito, Ichiro ; Hirata, Kazuki ; Miyamoto, Kazuya ; Shimizu, Takeshi ; Satomi, Hidetoshi ; Inagaki, Hiroshi ; Suzuki, Makoto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-eba040bf6777f2456c82823caf0fa056fda3db1d205c5f2ed7504036798b8bff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Actin</topic><topic>Anatomy</topic><topic>Androgen receptors</topic><topic>Asians</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Calponin</topic><topic>Carcinoma, Intraductal, Noninfiltrating - diagnosis</topic><topic>Carcinoma, Intraductal, Noninfiltrating - metabolism</topic><topic>Carcinoma, Intraductal, Noninfiltrating - surgery</topic><topic>Case Report</topic><topic>Case reports</topic><topic>Cytoplasm</topic><topic>ErbB Receptors - analysis</topic><topic>ErbB Receptors - genetics</topic><topic>Exocrine glands</topic><topic>Female</topic><topic>Fusion protein</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Genetic analysis</topic><topic>Growth patterns</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Japan</topic><topic>Keratin-19 - analysis</topic><topic>Keratin-19 - genetics</topic><topic>Keratin-5 - analysis</topic><topic>Keratin-5 - genetics</topic><topic>Keratin-6 - analysis</topic><topic>Keratin-6 - genetics</topic><topic>Leukocytes (eosinophilic)</topic><topic>Lip</topic><topic>Lip - surgery</topic><topic>Lip Neoplasms - diagnosis</topic><topic>Lip Neoplasms - metabolism</topic><topic>Lip Neoplasms - surgery</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Molecular Medicine</topic><topic>Nodules</topic><topic>Pathology</topic><topic>Phenotypes</topic><topic>Receptors, Androgen - analysis</topic><topic>Receptors, Androgen - genetics</topic><topic>S100 protein</topic><topic>Salivary gland</topic><topic>Smooth muscle</topic><topic>Sox10 protein</topic><topic>SOXE Transcription Factors - analysis</topic><topic>SOXE Transcription Factors - genetics</topic><topic>Tumor cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kusafuka, Kimihide</creatorcontrib><creatorcontrib>Ito, Ichiro</creatorcontrib><creatorcontrib>Hirata, Kazuki</creatorcontrib><creatorcontrib>Miyamoto, Kazuya</creatorcontrib><creatorcontrib>Shimizu, Takeshi</creatorcontrib><creatorcontrib>Satomi, Hidetoshi</creatorcontrib><creatorcontrib>Inagaki, Hiroshi</creatorcontrib><creatorcontrib>Suzuki, Makoto</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Medical molecular morphology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kusafuka, Kimihide</au><au>Ito, Ichiro</au><au>Hirata, Kazuki</au><au>Miyamoto, Kazuya</au><au>Shimizu, Takeshi</au><au>Satomi, Hidetoshi</au><au>Inagaki, Hiroshi</au><au>Suzuki, Makoto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A rare case of high-grade intraductal carcinoma of the upper lip: immunohistochemical and genetic analyses</atitle><jtitle>Medical molecular morphology</jtitle><stitle>Med Mol Morphol</stitle><addtitle>Med Mol Morphol</addtitle><date>2021-09-01</date><risdate>2021</risdate><volume>54</volume><issue>3</issue><spage>281</spage><epage>288</epage><pages>281-288</pages><issn>1860-1480</issn><eissn>1860-1499</eissn><abstract>Although intraductal carcinoma (IDC) of the salivary glands was previously called low-grade cribriform cystadenocarcinoma, it was newly categorized in the 4th version of the World Health Organization classification. We report a case of IDC of the upper lip and examined it immunohistochemically and genetically. The patient was a 48-year-old Japanese female, who noticed a tiny nodule on her left upper lip. Histologically, the tumor cells, which had eosinophilic cytoplasm, exhibited papillary and solid growth patterns, and regions of suspected microinvasion or intraductal spread were also seen at the periphery of the tumor. Small necrotic foci were noted. Immunohistochemically, the tumor cells were diffusely positive for the androgen receptor, CK19, CK5/6, EGFR, and SOX10, whereas they were focally positive for GCDFP-15, S-100 protein, and mammaglobin. The tumor nests were surrounded by alpha-smooth muscle actin-p63-/calponin-/CK14-positive myoepithelial cells. The Ki-67 labeling index was 51.2%. Genetic analysis showed no evidence of the
TRIM27-RET
or
NCOA4-RET
fusion gene. We finally diagnosed the tumor as a high-grade mixed intercalated duct/apocrine-type IDC of the upper lip. IDC of the minor salivary glands is exceedingly rare. We discuss diagnostic problems associated with minor salivary gland lesions, and the “basal-like” phenotype of this case.</abstract><cop>Singapore</cop><pub>Springer Singapore</pub><pmid>34009452</pmid><doi>10.1007/s00795-021-00291-9</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-5315-2540</orcidid></addata></record> |
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| ispartof | Medical molecular morphology, 2021-09, Vol.54 (3), p.281-288 |
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| subjects | Actin Anatomy Androgen receptors Asians Biomarkers, Tumor - analysis Calponin Carcinoma, Intraductal, Noninfiltrating - diagnosis Carcinoma, Intraductal, Noninfiltrating - metabolism Carcinoma, Intraductal, Noninfiltrating - surgery Case Report Case reports Cytoplasm ErbB Receptors - analysis ErbB Receptors - genetics Exocrine glands Female Fusion protein Gene Expression Regulation, Neoplastic Genetic analysis Growth patterns Humans Immunohistochemistry Japan Keratin-19 - analysis Keratin-19 - genetics Keratin-5 - analysis Keratin-5 - genetics Keratin-6 - analysis Keratin-6 - genetics Leukocytes (eosinophilic) Lip Lip - surgery Lip Neoplasms - diagnosis Lip Neoplasms - metabolism Lip Neoplasms - surgery Medicine Medicine & Public Health Middle Aged Molecular Medicine Nodules Pathology Phenotypes Receptors, Androgen - analysis Receptors, Androgen - genetics S100 protein Salivary gland Smooth muscle Sox10 protein SOXE Transcription Factors - analysis SOXE Transcription Factors - genetics Tumor cells |
| title | A rare case of high-grade intraductal carcinoma of the upper lip: immunohistochemical and genetic analyses |
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