Extremely Low Birth Weight and Accelerated Biological Aging
Extremely low birth weight (ELBW) (2500 g) control participants. Buccal cells were collected from 45 ELBW survivors and 49 NBW control participants at 30 to 35 years of age. Epigenetic age was calculated from the weighted average of DNA methylation at 353 cytosine-phosphate-guanine sequence within D...
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| Veröffentlicht in: | Pediatrics (Evanston) 2021-06, Vol.147 (6), p.1 |
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| container_title | Pediatrics (Evanston) |
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| creator | Van Lieshout, Ryan J McGowan, Patrick O de Vega, Wilfred C Savoy, Calan D Morrison, Katherine M Saigal, Saroj Mathewson, Karen J Schmidt, Louis A |
| description | Extremely low birth weight (ELBW) (2500 g) control participants.
Buccal cells were collected from 45 ELBW survivors and 49 NBW control participants at 30 to 35 years of age. Epigenetic age was calculated from the weighted average of DNA methylation at 353 cytosine-phosphate-guanine sequence within DNA sites, by using the Illumina Infinium Human Methylation EPIC 850k BeadChip array.
Before and after statistically adjusting for neurosensory impairment and the presence of chronic health conditions, a significant sex by birth weight group interaction was observed in the 353-site epigenetic-clock assay (
= .03), whereby ELBW men had a significantly older epigenetic age than NBW men (4.6 years;
= .01). Women born at ELBW were not found to be epigenetically older than their NBW peers.
The results of this study suggest that prenatal exposures may play an important role in aging, and that men born preterm may experience accelerated aging relative to their peers. We further highlight the need to monitor and promote the health of preterm survivors, with a particular focus on healthy aging across the life span. |
| doi_str_mv | 10.1542/peds.2020-001230 |
| format | Article |
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Buccal cells were collected from 45 ELBW survivors and 49 NBW control participants at 30 to 35 years of age. Epigenetic age was calculated from the weighted average of DNA methylation at 353 cytosine-phosphate-guanine sequence within DNA sites, by using the Illumina Infinium Human Methylation EPIC 850k BeadChip array.
Before and after statistically adjusting for neurosensory impairment and the presence of chronic health conditions, a significant sex by birth weight group interaction was observed in the 353-site epigenetic-clock assay (
= .03), whereby ELBW men had a significantly older epigenetic age than NBW men (4.6 years;
= .01). Women born at ELBW were not found to be epigenetically older than their NBW peers.
The results of this study suggest that prenatal exposures may play an important role in aging, and that men born preterm may experience accelerated aging relative to their peers. We further highlight the need to monitor and promote the health of preterm survivors, with a particular focus on healthy aging across the life span.</description><identifier>ISSN: 0031-4005</identifier><identifier>EISSN: 1098-4275</identifier><identifier>DOI: 10.1542/peds.2020-001230</identifier><identifier>PMID: 34001643</identifier><language>eng</language><publisher>United States: American Academy of Pediatrics</publisher><subject>Aging ; Aging (Biology) ; Birth weight ; Birth weight, Low ; Chronic illnesses ; Cohort Studies ; Cytosine ; Deoxyribonucleic acid ; DNA ; DNA methylation ; Epigenesis, Genetic ; Epigenetic inheritance ; Epigenetics ; Female ; Forecasts and trends ; Genetic aspects ; Guanine ; Humans ; Infant, Extremely Low Birth Weight ; Infant, Newborn ; Influence ; Life span ; Low birth weight ; Male ; Market trend/market analysis ; Nucleotide sequence ; Pediatrics ; Physiological aspects ; Prenatal experience</subject><ispartof>Pediatrics (Evanston), 2021-06, Vol.147 (6), p.1</ispartof><rights>Copyright © 2021 by the American Academy of Pediatrics.</rights><rights>COPYRIGHT 2021 American Academy of Pediatrics</rights><rights>Copyright American Academy of Pediatrics Jun 1, 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-ad48ee44df82b9e19966ff2e898807e02885d67c00b895ffca8ef5253ac1a4da3</citedby><cites>FETCH-LOGICAL-c365t-ad48ee44df82b9e19966ff2e898807e02885d67c00b895ffca8ef5253ac1a4da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34001643$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Van Lieshout, Ryan J</creatorcontrib><creatorcontrib>McGowan, Patrick O</creatorcontrib><creatorcontrib>de Vega, Wilfred C</creatorcontrib><creatorcontrib>Savoy, Calan D</creatorcontrib><creatorcontrib>Morrison, Katherine M</creatorcontrib><creatorcontrib>Saigal, Saroj</creatorcontrib><creatorcontrib>Mathewson, Karen J</creatorcontrib><creatorcontrib>Schmidt, Louis A</creatorcontrib><title>Extremely Low Birth Weight and Accelerated Biological Aging</title><title>Pediatrics (Evanston)</title><addtitle>Pediatrics</addtitle><description>Extremely low birth weight (ELBW) (<1000 g) survivors are exposed to elevated levels of physiologic stress during their lives and may be susceptible to accelerated aging. Using the oldest known longitudinally followed cohort of ELBW survivors, we compared biological aging in this group using an epigenetic clock to a sample of matched normal birth weight (NBW) (>2500 g) control participants.
Buccal cells were collected from 45 ELBW survivors and 49 NBW control participants at 30 to 35 years of age. Epigenetic age was calculated from the weighted average of DNA methylation at 353 cytosine-phosphate-guanine sequence within DNA sites, by using the Illumina Infinium Human Methylation EPIC 850k BeadChip array.
Before and after statistically adjusting for neurosensory impairment and the presence of chronic health conditions, a significant sex by birth weight group interaction was observed in the 353-site epigenetic-clock assay (
= .03), whereby ELBW men had a significantly older epigenetic age than NBW men (4.6 years;
= .01). Women born at ELBW were not found to be epigenetically older than their NBW peers.
The results of this study suggest that prenatal exposures may play an important role in aging, and that men born preterm may experience accelerated aging relative to their peers. We further highlight the need to monitor and promote the health of preterm survivors, with a particular focus on healthy aging across the life span.</description><subject>Aging</subject><subject>Aging (Biology)</subject><subject>Birth weight</subject><subject>Birth weight, Low</subject><subject>Chronic illnesses</subject><subject>Cohort Studies</subject><subject>Cytosine</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA methylation</subject><subject>Epigenesis, Genetic</subject><subject>Epigenetic inheritance</subject><subject>Epigenetics</subject><subject>Female</subject><subject>Forecasts and trends</subject><subject>Genetic aspects</subject><subject>Guanine</subject><subject>Humans</subject><subject>Infant, Extremely Low Birth Weight</subject><subject>Infant, Newborn</subject><subject>Influence</subject><subject>Life span</subject><subject>Low birth weight</subject><subject>Male</subject><subject>Market trend/market analysis</subject><subject>Nucleotide sequence</subject><subject>Pediatrics</subject><subject>Physiological aspects</subject><subject>Prenatal experience</subject><issn>0031-4005</issn><issn>1098-4275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkT1PwzAQhi0EglLYmVAkFpbA2bETR0ylKh9SpS4gRst1LmkqNy52Ktp_j6sCA9NJd8-dHt1LyBWFOyo4u19jFe4YMEgBKMvgiAwolDLlrBDHZACQ0ZQDiDNyHsISALgo2Ck5y2KT5jwbkIfJtve4QrtLpu4reWx9v0g-sG0WfaK7KhkZgxa97rGKQ2dd0xptk1HTds0FOam1DXj5U4fk_WnyNn5Jp7Pn1_FomposF32qKy4ROa9qyeYl0rLM87pmKEspoUBgUooqLwzAXJairo2WWAsmMm2o5pXOhuT2cHft3ecGQ69WbYhaVnfoNkExEU_QUsYPDMnNP3TpNr6LdpGKNhxKKCKVHqhGW1RtZ1zX47Y3zlpsUEX58UyNcsmpZILueTjwxrsQPNZq7duV9jtFQe2DUPsg1D4IdQgirlz_iGzmK6z-Fn4_n30D0z6BOg</recordid><startdate>202106</startdate><enddate>202106</enddate><creator>Van Lieshout, Ryan J</creator><creator>McGowan, Patrick O</creator><creator>de Vega, Wilfred C</creator><creator>Savoy, Calan D</creator><creator>Morrison, Katherine M</creator><creator>Saigal, Saroj</creator><creator>Mathewson, Karen J</creator><creator>Schmidt, Louis A</creator><general>American Academy of Pediatrics</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>202106</creationdate><title>Extremely Low Birth Weight and Accelerated Biological Aging</title><author>Van Lieshout, Ryan J ; 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Using the oldest known longitudinally followed cohort of ELBW survivors, we compared biological aging in this group using an epigenetic clock to a sample of matched normal birth weight (NBW) (>2500 g) control participants.
Buccal cells were collected from 45 ELBW survivors and 49 NBW control participants at 30 to 35 years of age. Epigenetic age was calculated from the weighted average of DNA methylation at 353 cytosine-phosphate-guanine sequence within DNA sites, by using the Illumina Infinium Human Methylation EPIC 850k BeadChip array.
Before and after statistically adjusting for neurosensory impairment and the presence of chronic health conditions, a significant sex by birth weight group interaction was observed in the 353-site epigenetic-clock assay (
= .03), whereby ELBW men had a significantly older epigenetic age than NBW men (4.6 years;
= .01). Women born at ELBW were not found to be epigenetically older than their NBW peers.
The results of this study suggest that prenatal exposures may play an important role in aging, and that men born preterm may experience accelerated aging relative to their peers. We further highlight the need to monitor and promote the health of preterm survivors, with a particular focus on healthy aging across the life span.</abstract><cop>United States</cop><pub>American Academy of Pediatrics</pub><pmid>34001643</pmid><doi>10.1542/peds.2020-001230</doi></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Aging Aging (Biology) Birth weight Birth weight, Low Chronic illnesses Cohort Studies Cytosine Deoxyribonucleic acid DNA DNA methylation Epigenesis, Genetic Epigenetic inheritance Epigenetics Female Forecasts and trends Genetic aspects Guanine Humans Infant, Extremely Low Birth Weight Infant, Newborn Influence Life span Low birth weight Male Market trend/market analysis Nucleotide sequence Pediatrics Physiological aspects Prenatal experience |
| title | Extremely Low Birth Weight and Accelerated Biological Aging |
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