MRI Analysis Of the Water Content Change In the Brain During Acute Ethanol Consumption Via Quantitative Water Mapping

MRI Analysis Of the Water Content Change In the Brain During Acute Ethanol Consumption Via Quantitative Water Mapping

Abstract Aims Alcohol consumption influences the water balance in the brain. While the impact of chronic alcohol misuse on cerebral water content has been the subject of several studies, less is known about the effects of acute alcohol misuse, with contradictory results in the literature. Therefore,...

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Veröffentlicht in:Alcohol and alcoholism (Oxford) 2022-07, Vol.57 (4), p.429-436
Hauptverfasser: Furtmann, Johanna K, Sichtermann, Thorsten, Oros-Peusquens, Ana-Maria, Dekeyzer, Sven, Shah, Nadim J, Wiesmann, Martin, Nikoubashman, Omid
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container_end_page 436
container_issue 4
container_start_page 429
container_title Alcohol and alcoholism (Oxford)
container_volume 57
creator Furtmann, Johanna K
Sichtermann, Thorsten
Oros-Peusquens, Ana-Maria
Dekeyzer, Sven
Shah, Nadim J
Wiesmann, Martin
Nikoubashman, Omid
description Abstract Aims Alcohol consumption influences the water balance in the brain. While the impact of chronic alcohol misuse on cerebral water content has been the subject of several studies, less is known about the effects of acute alcohol misuse, with contradictory results in the literature. Therefore, we investigated the effects of acute alcohol intoxication on cerebral water content using a precise quantitative magnetic resonance imaging (MRI) sequence. Methods In a prospective study, we measured cerebral water content in 20 healthy volunteers before alcohol consumption and after reaching a breath alcohol concentration of 1 ‰. A quantitative MRI water mapping sequence was conducted on a clinical 3 T system. Non-alcoholic fluid input and output were documented and accounted for. Water content was assessed for whole brain, grey and white matter and more specifically for regions known to be affected by acute or chronic alcohol misuse (occipital and frontal lobes, thalamus and pons). Changes in the volume of grey and white matter as well as the whole brain were examined. Results Quantitative cerebral water content before and after acute alcohol consumption did not differ significantly (P ≥ 0.07), with changes often being within the range of measurement accuracy. Whole brain, white and grey matter volume did not change significantly (P ≥ 0.12). Conclusion The results of our study show no significant water content or volume change in the brain after recent alcohol intake in healthy volunteers. This accounts for the whole brain, grey and white matter, occipital and frontal lobes, thalamus and pons. Short Summary: We applied a precise quantitative MRI water mapping sequence in a prospective study in 20 healthy, alcohol-intoxicated volunteers. No significant water content or volume change in the brain, after recent alcohol intake, was found in the whole brain, grey and white matter, occipital and frontal lobes, thalamus and pons.
doi_str_mv 10.1093/alcalc/agab026
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While the impact of chronic alcohol misuse on cerebral water content has been the subject of several studies, less is known about the effects of acute alcohol misuse, with contradictory results in the literature. Therefore, we investigated the effects of acute alcohol intoxication on cerebral water content using a precise quantitative magnetic resonance imaging (MRI) sequence. Methods In a prospective study, we measured cerebral water content in 20 healthy volunteers before alcohol consumption and after reaching a breath alcohol concentration of 1 ‰. A quantitative MRI water mapping sequence was conducted on a clinical 3 T system. Non-alcoholic fluid input and output were documented and accounted for. Water content was assessed for whole brain, grey and white matter and more specifically for regions known to be affected by acute or chronic alcohol misuse (occipital and frontal lobes, thalamus and pons). Changes in the volume of grey and white matter as well as the whole brain were examined. Results Quantitative cerebral water content before and after acute alcohol consumption did not differ significantly (P ≥ 0.07), with changes often being within the range of measurement accuracy. Whole brain, white and grey matter volume did not change significantly (P ≥ 0.12). Conclusion The results of our study show no significant water content or volume change in the brain after recent alcohol intake in healthy volunteers. This accounts for the whole brain, grey and white matter, occipital and frontal lobes, thalamus and pons. Short Summary: We applied a precise quantitative MRI water mapping sequence in a prospective study in 20 healthy, alcohol-intoxicated volunteers. No significant water content or volume change in the brain, after recent alcohol intake, was found in the whole brain, grey and white matter, occipital and frontal lobes, thalamus and pons.</description><identifier>ISSN: 0735-0414</identifier><identifier>EISSN: 1464-3502</identifier><identifier>DOI: 10.1093/alcalc/agab026</identifier><identifier>PMID: 34002208</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><ispartof>Alcohol and alcoholism (Oxford), 2022-07, Vol.57 (4), p.429-436</ispartof><rights>The Author(s) 2021. Medical Council on Alcohol and Oxford University Press. All rights reserved. 2021</rights><rights>The Author(s) 2021. Medical Council on Alcohol and Oxford University Press. 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While the impact of chronic alcohol misuse on cerebral water content has been the subject of several studies, less is known about the effects of acute alcohol misuse, with contradictory results in the literature. Therefore, we investigated the effects of acute alcohol intoxication on cerebral water content using a precise quantitative magnetic resonance imaging (MRI) sequence. Methods In a prospective study, we measured cerebral water content in 20 healthy volunteers before alcohol consumption and after reaching a breath alcohol concentration of 1 ‰. A quantitative MRI water mapping sequence was conducted on a clinical 3 T system. Non-alcoholic fluid input and output were documented and accounted for. Water content was assessed for whole brain, grey and white matter and more specifically for regions known to be affected by acute or chronic alcohol misuse (occipital and frontal lobes, thalamus and pons). Changes in the volume of grey and white matter as well as the whole brain were examined. Results Quantitative cerebral water content before and after acute alcohol consumption did not differ significantly (P ≥ 0.07), with changes often being within the range of measurement accuracy. Whole brain, white and grey matter volume did not change significantly (P ≥ 0.12). Conclusion The results of our study show no significant water content or volume change in the brain after recent alcohol intake in healthy volunteers. This accounts for the whole brain, grey and white matter, occipital and frontal lobes, thalamus and pons. Short Summary: We applied a precise quantitative MRI water mapping sequence in a prospective study in 20 healthy, alcohol-intoxicated volunteers. 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While the impact of chronic alcohol misuse on cerebral water content has been the subject of several studies, less is known about the effects of acute alcohol misuse, with contradictory results in the literature. Therefore, we investigated the effects of acute alcohol intoxication on cerebral water content using a precise quantitative magnetic resonance imaging (MRI) sequence. Methods In a prospective study, we measured cerebral water content in 20 healthy volunteers before alcohol consumption and after reaching a breath alcohol concentration of 1 ‰. A quantitative MRI water mapping sequence was conducted on a clinical 3 T system. Non-alcoholic fluid input and output were documented and accounted for. Water content was assessed for whole brain, grey and white matter and more specifically for regions known to be affected by acute or chronic alcohol misuse (occipital and frontal lobes, thalamus and pons). Changes in the volume of grey and white matter as well as the whole brain were examined. Results Quantitative cerebral water content before and after acute alcohol consumption did not differ significantly (P ≥ 0.07), with changes often being within the range of measurement accuracy. Whole brain, white and grey matter volume did not change significantly (P ≥ 0.12). Conclusion The results of our study show no significant water content or volume change in the brain after recent alcohol intake in healthy volunteers. This accounts for the whole brain, grey and white matter, occipital and frontal lobes, thalamus and pons. Short Summary: We applied a precise quantitative MRI water mapping sequence in a prospective study in 20 healthy, alcohol-intoxicated volunteers. No significant water content or volume change in the brain, after recent alcohol intake, was found in the whole brain, grey and white matter, occipital and frontal lobes, thalamus and pons.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>34002208</pmid><doi>10.1093/alcalc/agab026</doi><tpages>8</tpages></addata></record>
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title MRI Analysis Of the Water Content Change In the Brain During Acute Ethanol Consumption Via Quantitative Water Mapping
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