Novel SeS2-loaded Co MOF with Au@PANI comprised electroanalytical molecularly imprinted polymer-based disposable sensor for patulin mycotoxin

An SeS2-loaded Co MOF and Au@PANI nanocomposite comprising the base matrix of the electrode was developed with electropolymerized molecularly imprinted polymer (MIP) consisting of p-aminobenzoic acid (PABA) and patulin (PT) to detect PT molecules based on the PT imprinted cavities. SeS2@Co MOF and A...

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Veröffentlicht in:Biosensors & bioelectronics 2021-09, Vol.187, p.113302-113302, Article 113302
Hauptverfasser: Selvam, Sathish Panneer, Kadam, Abhijit N., Maiyelvaganan, K. Rudharachari, Prakash, Muthuramalingam, Cho, Sungbo
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container_title Biosensors & bioelectronics
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creator Selvam, Sathish Panneer
Kadam, Abhijit N.
Maiyelvaganan, K. Rudharachari
Prakash, Muthuramalingam
Cho, Sungbo
description An SeS2-loaded Co MOF and Au@PANI nanocomposite comprising the base matrix of the electrode was developed with electropolymerized molecularly imprinted polymer (MIP) consisting of p-aminobenzoic acid (PABA) and patulin (PT) to detect PT molecules based on the PT imprinted cavities. SeS2@Co MOF and Au@PANI were synthesized using hydrothermal synthesis and interfacial polymerization strategies, respectively. A suitable functional monomer to fabricate the MIP platform was selected using the density functional theory (DFT/M06-2X method). Higher electrochemical active surface area (0.985 cm2 which is 6.99 times higher than the bare SPE) and a lower charge transfer resistance (Rct = 27.8 Ω) at the MIP/Au@PANI/SeS2@Co MOF electrode was achieved based on the higher number of adsorptive sites and enhanced conductivity (electron transfer rate constant (ks = 3.24 × 10−3 s−1) of the sensing platform. The fabricated MIP sensor performance was studied in 10 mM PBS (pH = 6.4), where an improved detection limit (0.66 pM) for PT and a broad logarithmic linear dynamic range (0.001–100 nM) were both observed. The sensor possessed higher selectivity (Imprinting factor = 15.4 for PT), excellent reusability (%RSD of 10 cycles = 2.49%), high storage stability (6.7% lost after 35 days), and robust reproducibility (%RSD = 3.22%) The as-prepared MIP-based PT sensor was applied to detect PT in a real-time apple juice sample (10% diluted with PBS) with a recovery % ranging from 94.5 to 106.4%. The proposed sensor possesses great advantages in terms of cost-effectiveness, providing a simple detection strategy for long-term storage stability, and reversible cycle measurements. [Display omitted] •A novel SeS2 incorporated Co MOF and Au@PANI nanocomposite was developed.•PABA was optimized as a suitable functional monomer based on the density functional theory.•The developed MIP exhibited a large number of PT binding sites with higher binding energy.•Au@PANI/SeS2@Co MOF generated an excellent electrochemical response.•The sensor shows excellent selectivity, long-term stability and reversible behavior.
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Higher electrochemical active surface area (0.985 cm2 which is 6.99 times higher than the bare SPE) and a lower charge transfer resistance (Rct = 27.8 Ω) at the MIP/Au@PANI/SeS2@Co MOF electrode was achieved based on the higher number of adsorptive sites and enhanced conductivity (electron transfer rate constant (ks = 3.24 × 10−3 s−1) of the sensing platform. The fabricated MIP sensor performance was studied in 10 mM PBS (pH = 6.4), where an improved detection limit (0.66 pM) for PT and a broad logarithmic linear dynamic range (0.001–100 nM) were both observed. The sensor possessed higher selectivity (Imprinting factor = 15.4 for PT), excellent reusability (%RSD of 10 cycles = 2.49%), high storage stability (6.7% lost after 35 days), and robust reproducibility (%RSD = 3.22%) The as-prepared MIP-based PT sensor was applied to detect PT in a real-time apple juice sample (10% diluted with PBS) with a recovery % ranging from 94.5 to 106.4%. 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Rudharachari</au><au>Prakash, Muthuramalingam</au><au>Cho, Sungbo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel SeS2-loaded Co MOF with Au@PANI comprised electroanalytical molecularly imprinted polymer-based disposable sensor for patulin mycotoxin</atitle><jtitle>Biosensors &amp; bioelectronics</jtitle><stitle>BIOSENS BIOELECTRON</stitle><addtitle>Biosens Bioelectron</addtitle><date>2021-09-01</date><risdate>2021</risdate><volume>187</volume><spage>113302</spage><epage>113302</epage><pages>113302-113302</pages><artnum>113302</artnum><issn>0956-5663</issn><eissn>1873-4235</eissn><abstract>An SeS2-loaded Co MOF and Au@PANI nanocomposite comprising the base matrix of the electrode was developed with electropolymerized molecularly imprinted polymer (MIP) consisting of p-aminobenzoic acid (PABA) and patulin (PT) to detect PT molecules based on the PT imprinted cavities. SeS2@Co MOF and Au@PANI were synthesized using hydrothermal synthesis and interfacial polymerization strategies, respectively. A suitable functional monomer to fabricate the MIP platform was selected using the density functional theory (DFT/M06-2X method). Higher electrochemical active surface area (0.985 cm2 which is 6.99 times higher than the bare SPE) and a lower charge transfer resistance (Rct = 27.8 Ω) at the MIP/Au@PANI/SeS2@Co MOF electrode was achieved based on the higher number of adsorptive sites and enhanced conductivity (electron transfer rate constant (ks = 3.24 × 10−3 s−1) of the sensing platform. The fabricated MIP sensor performance was studied in 10 mM PBS (pH = 6.4), where an improved detection limit (0.66 pM) for PT and a broad logarithmic linear dynamic range (0.001–100 nM) were both observed. The sensor possessed higher selectivity (Imprinting factor = 15.4 for PT), excellent reusability (%RSD of 10 cycles = 2.49%), high storage stability (6.7% lost after 35 days), and robust reproducibility (%RSD = 3.22%) The as-prepared MIP-based PT sensor was applied to detect PT in a real-time apple juice sample (10% diluted with PBS) with a recovery % ranging from 94.5 to 106.4%. The proposed sensor possesses great advantages in terms of cost-effectiveness, providing a simple detection strategy for long-term storage stability, and reversible cycle measurements. [Display omitted] •A novel SeS2 incorporated Co MOF and Au@PANI nanocomposite was developed.•PABA was optimized as a suitable functional monomer based on the density functional theory.•The developed MIP exhibited a large number of PT binding sites with higher binding energy.•Au@PANI/SeS2@Co MOF generated an excellent electrochemical response.•The sensor shows excellent selectivity, long-term stability and reversible behavior.</abstract><cop>OXFORD</cop><pub>Elsevier B.V</pub><pmid>34000454</pmid><doi>10.1016/j.bios.2021.113302</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-1886-7708</orcidid><orcidid>https://orcid.org/0000-0002-9704-9139</orcidid><orcidid>https://orcid.org/0000-0003-3839-6410</orcidid></addata></record>
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subjects Biophysics
Biotechnology & Applied Microbiology
Chemistry
Chemistry, Analytical
Density functional theory
Electrochemistry
Life Sciences & Biomedicine
Molecularly imprinted polymer
Mycotoxin
Nanoscience & Nanotechnology
Patulin
Physical Sciences
Science & Technology
Science & Technology - Other Topics
SeS2-Loaded Co MOF
title Novel SeS2-loaded Co MOF with Au@PANI comprised electroanalytical molecularly imprinted polymer-based disposable sensor for patulin mycotoxin
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