Aromatic Polyketides and Hydroxamate Siderophores from a Marine-Algae-Derived Streptomyces Species

Aromatic Polyketides and Hydroxamate Siderophores from a Marine-Algae-Derived Streptomyces Species

Four new aromatic polyketides, wailupemycins M–P (1–4), and two new hydroxamate siderophores, streptamides A (5) and B (6), together with the previously reported nocardamine (7), were isolated from the marine-algae-derived Streptomyces sp. OUCMDZ-3434. Wailupemycins M–P (1–4), possessing an α-pyrone...

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Veröffentlicht in:Journal of natural products (Washington, D.C.) D.C.), 2021-05, Vol.84 (5), p.1550-1555
Hauptverfasser: Xia, Kunyu, Luo, Hui, Ma, Rui, Zhang, Rongxin, Zhu, Weiming, Fu, Peng
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container_issue 5
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container_title Journal of natural products (Washington, D.C.)
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creator Xia, Kunyu
Luo, Hui
Ma, Rui
Zhang, Rongxin
Zhu, Weiming
Fu, Peng
description Four new aromatic polyketides, wailupemycins M–P (1–4), and two new hydroxamate siderophores, streptamides A (5) and B (6), together with the previously reported nocardamine (7), were isolated from the marine-algae-derived Streptomyces sp. OUCMDZ-3434. Wailupemycins M–P (1–4), possessing an α-pyrone moiety, were isolated from the extract of a liquid fermentation, and the siderophores (5–7) were isolated from the extract of a solid fermentation. Their structures were assigned based on detailed spectroscopic analysis and quantum chemical calculations. Compounds 5–7 were capable of binding Fe­(III). Compound 5 can form a tighter Fe­(III) complex than that of deferoxamine B mesylate (DFB).
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