The Polyamine Regulator AMD1 Upregulates Spermine Levels to Drive Epidermal Differentiation

Maintaining tissue homeostasis depends on a balance between cell proliferation, differentiation, and apoptosis. Within the epidermis, the levels of the polyamines putrescine, spermidine, and spermine are altered in many different skin conditions, yet their role in epidermal tissue homeostasis is poo...

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Veröffentlicht in:	Journal of investigative dermatology 2021-09, Vol.141 (9), p.2178-2188.e6
Hauptverfasser:	Rahim, Anisa B., Lim, Hui Kheng, Tan, Christina Yan Ru, Jia, Li, Leo, Vonny Ivon, Uemura, Takeshi, Hardman-Smart, Jonathan, Common, John E.A., Lim, Thiam Chye, Bellanger, Sophie, Paus, Ralf, Igarashi, Kazuei, Yang, Henry, Vardy, Leah A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosylmethionine Decarboxylase - genetics Adenosylmethionine Decarboxylase - metabolism Animals Cell Differentiation Cell Proliferation Cells, Cultured Epidermal Cells - metabolism Epidermal Cells - pathology Gene Knockdown Techniques Humans Kruppel-Like Factor 4 - metabolism Mice Polyamines - metabolism Signal Transduction Spermine - metabolism Transcription Factors - metabolism Tumor Suppressor Proteins - metabolism Up-Regulation
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