Incidence of enterovirus in patients with acute gastroenteritis
Enteroviruses (EV) have been linked to lymphocytic meningitis and exanthems, but they may also be involved in acute gastroenteritis (AGE), a condition whose aetiological agent often remains unidentified. In this work 1214 samples from individuals with AGE were studied with the aim of establishing th...
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| Veröffentlicht in: | European journal of clinical microbiology & infectious diseases 2021-10, Vol.40 (10), p.2185-2190 |
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| creator | Pérez-Martínez, Z. Álvarez-Argüelles, M. E. Rojo-Alba, S. Castello-Abietar, C. Boga, J. A. Morilla-Morilla, A. Vivanco-Allende, A. Rodríguez-Suárez, J. Alonso-Álvarez, M. A. Melón, S. |
| description | Enteroviruses (EV) have been linked to lymphocytic meningitis and exanthems, but they may also be involved in acute gastroenteritis (AGE), a condition whose aetiological agent often remains unidentified. In this work 1214 samples from individuals with AGE were studied with the aim of establishing the incidence of EV. The samples were collected between September and December in three different years and subjected to real-time genomic amplification in order to determine the viral load (VL). Of the 1214 samples studied, infection by a single virus was found in 328 cases (27%) and coinfection in 69 (5.7%). While adenoviruses (AdV) were the most frequent (14.8% of total), EV were present in 126 (10.4%) of the individuals tested. Of the 126 EV-positive samples, this virus was found as a single infection and coinfection in 76 (6.3%) and 50 (4.1%) cases, respectively. VL for EV was 5.58±1.51 log copies/ml (range 3.73–9.69) in the former and 6.27±1.75 (range 3.73–10.5) (p=0.02) in the latter. EV were identified in 97 children under 5 (16.9%) and in 29 (4.5%) patients over 5. Patients less than 5 years showed a higher VL that those more than 5 years age [6.08±1.57 (range 3.82–9.69) vs. 5.07±1.53 (range 3.73–10.58); (p=0.002)]. There was a high incidence of EV in AGE patients, and they were more frequent in those under 5, where they were found to replicate more efficiently. These results therefore indicate that testing for EV should be included in the diagnosis of AGE. |
| doi_str_mv | 10.1007/s10096-021-04275-6 |
| format | Article |
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E. ; Rojo-Alba, S. ; Castello-Abietar, C. ; Boga, J. A. ; Morilla-Morilla, A. ; Vivanco-Allende, A. ; Rodríguez-Suárez, J. ; Alonso-Álvarez, M. A. ; Melón, S.</creator><creatorcontrib>Pérez-Martínez, Z. ; Álvarez-Argüelles, M. E. ; Rojo-Alba, S. ; Castello-Abietar, C. ; Boga, J. A. ; Morilla-Morilla, A. ; Vivanco-Allende, A. ; Rodríguez-Suárez, J. ; Alonso-Álvarez, M. A. ; Melón, S.</creatorcontrib><description>Enteroviruses (EV) have been linked to lymphocytic meningitis and exanthems, but they may also be involved in acute gastroenteritis (AGE), a condition whose aetiological agent often remains unidentified. In this work 1214 samples from individuals with AGE were studied with the aim of establishing the incidence of EV. The samples were collected between September and December in three different years and subjected to real-time genomic amplification in order to determine the viral load (VL). Of the 1214 samples studied, infection by a single virus was found in 328 cases (27%) and coinfection in 69 (5.7%). While adenoviruses (AdV) were the most frequent (14.8% of total), EV were present in 126 (10.4%) of the individuals tested. Of the 126 EV-positive samples, this virus was found as a single infection and coinfection in 76 (6.3%) and 50 (4.1%) cases, respectively. VL for EV was 5.58±1.51 log copies/ml (range 3.73–9.69) in the former and 6.27±1.75 (range 3.73–10.5) (p=0.02) in the latter. EV were identified in 97 children under 5 (16.9%) and in 29 (4.5%) patients over 5. Patients less than 5 years showed a higher VL that those more than 5 years age [6.08±1.57 (range 3.82–9.69) vs. 5.07±1.53 (range 3.73–10.58); (p=0.002)]. There was a high incidence of EV in AGE patients, and they were more frequent in those under 5, where they were found to replicate more efficiently. These results therefore indicate that testing for EV should be included in the diagnosis of AGE.</description><identifier>ISSN: 0934-9723</identifier><identifier>EISSN: 1435-4373</identifier><identifier>DOI: 10.1007/s10096-021-04275-6</identifier><identifier>PMID: 33987803</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adenoviruses ; Age ; Biomedical and Life Sciences ; Biomedicine ; Child ; Child, Preschool ; Coinfection - epidemiology ; Coinfection - virology ; Enterovirus - classification ; Enterovirus - genetics ; Enterovirus - isolation & purification ; Enterovirus - physiology ; Enterovirus Infections - epidemiology ; Enterovirus Infections - virology ; Enteroviruses ; Feces - virology ; Female ; Gastroenteritis ; Gastroenteritis - epidemiology ; Gastroenteritis - virology ; Genotype ; Humans ; Infant ; Internal Medicine ; Male ; Medical Microbiology ; Meningitis ; Original Article ; Phylogeny ; Viral Load</subject><ispartof>European journal of clinical microbiology & infectious diseases, 2021-10, Vol.40 (10), p.2185-2190</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-b8c6ea238bee9651aa973a0c428c518649bcdf193138cdb1dff4d12297983bfe3</citedby><cites>FETCH-LOGICAL-c375t-b8c6ea238bee9651aa973a0c428c518649bcdf193138cdb1dff4d12297983bfe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10096-021-04275-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10096-021-04275-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33987803$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pérez-Martínez, Z.</creatorcontrib><creatorcontrib>Álvarez-Argüelles, M. E.</creatorcontrib><creatorcontrib>Rojo-Alba, S.</creatorcontrib><creatorcontrib>Castello-Abietar, C.</creatorcontrib><creatorcontrib>Boga, J. A.</creatorcontrib><creatorcontrib>Morilla-Morilla, A.</creatorcontrib><creatorcontrib>Vivanco-Allende, A.</creatorcontrib><creatorcontrib>Rodríguez-Suárez, J.</creatorcontrib><creatorcontrib>Alonso-Álvarez, M. A.</creatorcontrib><creatorcontrib>Melón, S.</creatorcontrib><title>Incidence of enterovirus in patients with acute gastroenteritis</title><title>European journal of clinical microbiology & infectious diseases</title><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><description>Enteroviruses (EV) have been linked to lymphocytic meningitis and exanthems, but they may also be involved in acute gastroenteritis (AGE), a condition whose aetiological agent often remains unidentified. In this work 1214 samples from individuals with AGE were studied with the aim of establishing the incidence of EV. The samples were collected between September and December in three different years and subjected to real-time genomic amplification in order to determine the viral load (VL). Of the 1214 samples studied, infection by a single virus was found in 328 cases (27%) and coinfection in 69 (5.7%). While adenoviruses (AdV) were the most frequent (14.8% of total), EV were present in 126 (10.4%) of the individuals tested. Of the 126 EV-positive samples, this virus was found as a single infection and coinfection in 76 (6.3%) and 50 (4.1%) cases, respectively. VL for EV was 5.58±1.51 log copies/ml (range 3.73–9.69) in the former and 6.27±1.75 (range 3.73–10.5) (p=0.02) in the latter. EV were identified in 97 children under 5 (16.9%) and in 29 (4.5%) patients over 5. Patients less than 5 years showed a higher VL that those more than 5 years age [6.08±1.57 (range 3.82–9.69) vs. 5.07±1.53 (range 3.73–10.58); (p=0.002)]. There was a high incidence of EV in AGE patients, and they were more frequent in those under 5, where they were found to replicate more efficiently. These results therefore indicate that testing for EV should be included in the diagnosis of AGE.</description><subject>Adenoviruses</subject><subject>Age</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Coinfection - epidemiology</subject><subject>Coinfection - virology</subject><subject>Enterovirus - classification</subject><subject>Enterovirus - genetics</subject><subject>Enterovirus - isolation & purification</subject><subject>Enterovirus - physiology</subject><subject>Enterovirus Infections - epidemiology</subject><subject>Enterovirus Infections - virology</subject><subject>Enteroviruses</subject><subject>Feces - virology</subject><subject>Female</subject><subject>Gastroenteritis</subject><subject>Gastroenteritis - epidemiology</subject><subject>Gastroenteritis - virology</subject><subject>Genotype</subject><subject>Humans</subject><subject>Infant</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medical Microbiology</subject><subject>Meningitis</subject><subject>Original Article</subject><subject>Phylogeny</subject><subject>Viral Load</subject><issn>0934-9723</issn><issn>1435-4373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kE9LwzAYh4Mobk6_gAcpePESTfK2TXISGf4ZCF70HNI0nRlbO5NU8dubrVPBg5e8kPf5_RIehE4puaSE8KuQTlliwigmOeMFLvfQmOZQ4Bw47KMxkZBjyRmM0FEIC5JCgvNDNAKQggsCY3Q9a42rbWts1jWZbaP13bvzfchcm611dOkqZB8uvmba9NFmcx2i77agiy4co4NGL4M92c0Jerm7fZ4-4Men-9n05hEb4EXElTCl1QxEZa0sC6q15KCJyZkwBRVlLitTN1QCBWHqitZNk9eUMcmlgKqxMEEXQ-_ad2-9DVGtXDB2udSt7fqgWMEE3cAioed_0EXX-zb9LlEcJC2By0SxgTK-C8HbRq29W2n_qShRG71q0KuSXrXVq8oUOttV99XK1j-Rb58JgAEIadXOrf99-5_aL9CVhSo</recordid><startdate>20211001</startdate><enddate>20211001</enddate><creator>Pérez-Martínez, Z.</creator><creator>Álvarez-Argüelles, M. 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E.</au><au>Rojo-Alba, S.</au><au>Castello-Abietar, C.</au><au>Boga, J. A.</au><au>Morilla-Morilla, A.</au><au>Vivanco-Allende, A.</au><au>Rodríguez-Suárez, J.</au><au>Alonso-Álvarez, M. A.</au><au>Melón, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incidence of enterovirus in patients with acute gastroenteritis</atitle><jtitle>European journal of clinical microbiology & infectious diseases</jtitle><stitle>Eur J Clin Microbiol Infect Dis</stitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><date>2021-10-01</date><risdate>2021</risdate><volume>40</volume><issue>10</issue><spage>2185</spage><epage>2190</epage><pages>2185-2190</pages><issn>0934-9723</issn><eissn>1435-4373</eissn><abstract>Enteroviruses (EV) have been linked to lymphocytic meningitis and exanthems, but they may also be involved in acute gastroenteritis (AGE), a condition whose aetiological agent often remains unidentified. In this work 1214 samples from individuals with AGE were studied with the aim of establishing the incidence of EV. The samples were collected between September and December in three different years and subjected to real-time genomic amplification in order to determine the viral load (VL). Of the 1214 samples studied, infection by a single virus was found in 328 cases (27%) and coinfection in 69 (5.7%). While adenoviruses (AdV) were the most frequent (14.8% of total), EV were present in 126 (10.4%) of the individuals tested. Of the 126 EV-positive samples, this virus was found as a single infection and coinfection in 76 (6.3%) and 50 (4.1%) cases, respectively. VL for EV was 5.58±1.51 log copies/ml (range 3.73–9.69) in the former and 6.27±1.75 (range 3.73–10.5) (p=0.02) in the latter. EV were identified in 97 children under 5 (16.9%) and in 29 (4.5%) patients over 5. Patients less than 5 years showed a higher VL that those more than 5 years age [6.08±1.57 (range 3.82–9.69) vs. 5.07±1.53 (range 3.73–10.58); (p=0.002)]. There was a high incidence of EV in AGE patients, and they were more frequent in those under 5, where they were found to replicate more efficiently. These results therefore indicate that testing for EV should be included in the diagnosis of AGE.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33987803</pmid><doi>10.1007/s10096-021-04275-6</doi><tpages>6</tpages></addata></record> |
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| subjects | Adenoviruses Age Biomedical and Life Sciences Biomedicine Child Child, Preschool Coinfection - epidemiology Coinfection - virology Enterovirus - classification Enterovirus - genetics Enterovirus - isolation & purification Enterovirus - physiology Enterovirus Infections - epidemiology Enterovirus Infections - virology Enteroviruses Feces - virology Female Gastroenteritis Gastroenteritis - epidemiology Gastroenteritis - virology Genotype Humans Infant Internal Medicine Male Medical Microbiology Meningitis Original Article Phylogeny Viral Load |
| title | Incidence of enterovirus in patients with acute gastroenteritis |
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