Membrane anchoring of a curvature-inducing peptide, EpN18, promotes membrane translocation of octaarginine

[Display omitted] EpN18 is a curvature-inducing peptide, which loosens lipid packing upon interaction with the cell membrane, and facilitates cell-membrane penetration by arginine-rich cell-penetrating peptides, including octaarginine (R8). In the present study, we conjugated the N-terminal of EpN18...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2021-07, Vol.43, p.128103-128103, Article 128103
Hauptverfasser:	Kuroki, Kakeru, Sakai, Takayuki, Masuda, Toshihiro, Kawano, Kenichi, Futaki, Shiroh
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell membrane translocation Curvature-inducing peptide Lipid packing loosening Octaarginine Pyrenebutyric acid
Online-Zugang:	Volltext
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