Increased sarcolemma chloride conductance as one of the mechanisms of action of carbonic anhydrase inhibitors in muscle excitability disorders

To get insight into the mechanism of action of carbonic anhydrase inhibitors (CAI) in neuromuscular disorders, we investigated effects of dichlorphenamide (DCP) and acetazolamide (ACTZ) on ClC-1 chloride channels and skeletal muscle excitability. We performed patch-clamp experiments to test drugs on...

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Veröffentlicht in:	Experimental neurology 2021-08, Vol.342, p.113758-113758, Article 113758
Hauptverfasser:	Altamura, Concetta, Fonzino, Adriano, Tarantino, Nancy, Conte, Elena, Liantonio, Antonella, Imbrici, Paola, Carratù, Maria Rosaria, Pierno, Sabata, Desaphy, Jean-François
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetazolamide Carbonic anhydrase inhibitors ClC-1 chloride channel Dichlorphenamide Myotonia Sarcolemma excitability
Online-Zugang:	Volltext
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