Chrysin Improves Glucose and Lipid Metabolism Disorders by Regulating the AMPK/PI3K/AKT Signaling Pathway in Insulin-Resistant HepG2 Cells and HFD/STZ-Induced C57BL/6J Mice

Natural products with minor side effects have been reported to be an effective adjuvant therapy for glucose and lipid metabolism disorders. Chrysin, a flavone, has a wide range of physiological effects, such as antioxidant, anti-inflammatory, anti-diabetes, anti-hyperlipidemia, and hepatoprotective....

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Veröffentlicht in:	Journal of agricultural and food chemistry 2021-05, Vol.69 (20), p.5618-5627
Hauptverfasser:	Zhou, Ying-Jun, Xu, Nuo, Zhang, Xiao-Chen, Zhu, Yu-Yan, Liu, Shao-Wei, Chang, Ya-Ning
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases - genetics AMP-Activated Protein Kinases - metabolism Animals Bioactive Constituents, Metabolites, and Functions Flavonoids Glucose Hep G2 Cells Humans Insulin - metabolism Insulin Resistance Lipid Metabolism Lipid Metabolism Disorders Mice Mice, Inbred C57BL Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Signal Transduction
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