Association between serum level of C-reactive protein and risk of cardiovascular events based on cohort studies
Although the association between serum level of C-reactive protein (CRP) and risk of cardiovascular events (CVEs) has been reported, the comprehensive assessment of the quantitative association of CRP level with risk of CVEs has not been reported. Our meta-analysis aims to quantitatively evaluate th...
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| Veröffentlicht in: | Journal of human hypertension 2021-12, Vol.35 (12), p.1149-1158 |
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| creator | Yang, Xingjin Zhang, Dongdong Zhao, Yang Liu, Dechen Li, Quanman Guo, Chunmei Tian, Gang Han, Minghui Qie, Ranran Huang, Shengbing Zhou, Qionggui Feng, Yifei Wu, Xiaoyan Zhang, Yanyan Li, Yang Wu, Yuying Cheng, Cheng Hu, Dongsheng Sun, Liang |
| description | Although the association between serum level of C-reactive protein (CRP) and risk of cardiovascular events (CVEs) has been reported, the comprehensive assessment of the quantitative association of CRP level with risk of CVEs has not been reported. Our meta-analysis aims to quantitatively evaluate the association of CRP level and risk of CVEs. We searched PubMed and Embase databases for articles published up to December 6, 2019. Studies with data on men and women, different types of CVEs and multiple cohorts within a study were treated as independent studies. Generalized least-squares regression models were used to assess the quantitative association between CRP level and risk of CVEs. Restricted cubic splines were used to model the possible linear association between CRP and CVEs. We included 36 articles (60 studies; 227,715 participants) in the analysis. The pooled relative risks (RRs) of high versus low CRP level for cardiovascular disease (CVD), stroke and coronary heart disease (CHD) were 1.64 (95% confidence interval [CI], 1.49–1.82), 1.46 (95% CI, 1.35–1.58), and 1.55 (95% CI, 1.47–1.63), respectively. A linear association was found between CRP level and CVD (
P
= 0.429), stroke (
P
= 0.940), and CHD (
P
= 0.931); with each 1-mg/L increase in CRP level, the pooled RRs for CVD, stroke, and CHD were 1.18 (95% CI, 1.12–1.24), 1.07 (95% CI, 1.04–1.09), and 1.12 (95% CI, 1.08–1.16), respectively. This meta-analysis suggests that risk of CVEs increases with increasing serum CRP level. |
| doi_str_mv | 10.1038/s41371-021-00546-z |
| format | Article |
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P
= 0.429), stroke (
P
= 0.940), and CHD (
P
= 0.931); with each 1-mg/L increase in CRP level, the pooled RRs for CVD, stroke, and CHD were 1.18 (95% CI, 1.12–1.24), 1.07 (95% CI, 1.04–1.09), and 1.12 (95% CI, 1.08–1.16), respectively. This meta-analysis suggests that risk of CVEs increases with increasing serum CRP level.</description><identifier>ISSN: 0950-9240</identifier><identifier>EISSN: 1476-5527</identifier><identifier>DOI: 10.1038/s41371-021-00546-z</identifier><identifier>PMID: 33980977</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/499 ; 692/699/75 ; 692/699/75/230 ; 82 ; 82/1 ; C-Reactive Protein ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - epidemiology ; Cohort analysis ; Cohort Studies ; Coronary artery disease ; Diagnosis ; Epidemiology ; Health Administration ; Health aspects ; Heart diseases ; Humans ; Measurement ; Medicine ; Medicine & Public Health ; Meta-analysis ; Public Health ; Regression analysis ; Review Article ; Risk assessment ; Risk factors ; Stroke</subject><ispartof>Journal of human hypertension, 2021-12, Vol.35 (12), p.1149-1158</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Limited 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer Nature Limited.</rights><rights>COPYRIGHT 2021 Nature Publishing Group</rights><rights>The Author(s), under exclusive licence to Springer Nature Limited 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c473t-8a78af9856342f06bf001e5e095e9b034117ceccada84e8677bc774023b2d2543</citedby><cites>FETCH-LOGICAL-c473t-8a78af9856342f06bf001e5e095e9b034117ceccada84e8677bc774023b2d2543</cites><orcidid>0000-0002-9998-8041 ; 0000-0002-9795-3574</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33980977$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Xingjin</creatorcontrib><creatorcontrib>Zhang, Dongdong</creatorcontrib><creatorcontrib>Zhao, Yang</creatorcontrib><creatorcontrib>Liu, Dechen</creatorcontrib><creatorcontrib>Li, Quanman</creatorcontrib><creatorcontrib>Guo, Chunmei</creatorcontrib><creatorcontrib>Tian, Gang</creatorcontrib><creatorcontrib>Han, Minghui</creatorcontrib><creatorcontrib>Qie, Ranran</creatorcontrib><creatorcontrib>Huang, Shengbing</creatorcontrib><creatorcontrib>Zhou, Qionggui</creatorcontrib><creatorcontrib>Feng, Yifei</creatorcontrib><creatorcontrib>Wu, Xiaoyan</creatorcontrib><creatorcontrib>Zhang, Yanyan</creatorcontrib><creatorcontrib>Li, Yang</creatorcontrib><creatorcontrib>Wu, Yuying</creatorcontrib><creatorcontrib>Cheng, Cheng</creatorcontrib><creatorcontrib>Hu, Dongsheng</creatorcontrib><creatorcontrib>Sun, Liang</creatorcontrib><title>Association between serum level of C-reactive protein and risk of cardiovascular events based on cohort studies</title><title>Journal of human hypertension</title><addtitle>J Hum Hypertens</addtitle><addtitle>J Hum Hypertens</addtitle><description>Although the association between serum level of C-reactive protein (CRP) and risk of cardiovascular events (CVEs) has been reported, the comprehensive assessment of the quantitative association of CRP level with risk of CVEs has not been reported. Our meta-analysis aims to quantitatively evaluate the association of CRP level and risk of CVEs. We searched PubMed and Embase databases for articles published up to December 6, 2019. Studies with data on men and women, different types of CVEs and multiple cohorts within a study were treated as independent studies. Generalized least-squares regression models were used to assess the quantitative association between CRP level and risk of CVEs. Restricted cubic splines were used to model the possible linear association between CRP and CVEs. We included 36 articles (60 studies; 227,715 participants) in the analysis. The pooled relative risks (RRs) of high versus low CRP level for cardiovascular disease (CVD), stroke and coronary heart disease (CHD) were 1.64 (95% confidence interval [CI], 1.49–1.82), 1.46 (95% CI, 1.35–1.58), and 1.55 (95% CI, 1.47–1.63), respectively. A linear association was found between CRP level and CVD (
P
= 0.429), stroke (
P
= 0.940), and CHD (
P
= 0.931); with each 1-mg/L increase in CRP level, the pooled RRs for CVD, stroke, and CHD were 1.18 (95% CI, 1.12–1.24), 1.07 (95% CI, 1.04–1.09), and 1.12 (95% CI, 1.08–1.16), respectively. This meta-analysis suggests that risk of CVEs increases with increasing serum CRP level.</description><subject>692/499</subject><subject>692/699/75</subject><subject>692/699/75/230</subject><subject>82</subject><subject>82/1</subject><subject>C-Reactive Protein</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - diagnosis</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Coronary artery disease</subject><subject>Diagnosis</subject><subject>Epidemiology</subject><subject>Health Administration</subject><subject>Health aspects</subject><subject>Heart diseases</subject><subject>Humans</subject><subject>Measurement</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Meta-analysis</subject><subject>Public Health</subject><subject>Regression analysis</subject><subject>Review Article</subject><subject>Risk assessment</subject><subject>Risk factors</subject><subject>Stroke</subject><issn>0950-9240</issn><issn>1476-5527</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kl1rFDEUhoModq3-AS8kIIg3U_M5mblcFr-g4I1eh0zmTDd1ZlJzMlvsrzfjVmtFJIRAzvO-nJO8hDzn7Iwz2bxBxaXhFRNlM63q6uYB2XBl6kprYR6SDWs1q1qh2Al5gnjJ2FpsHpMTKduGtcZsSNwiRh9cDnGmHeRrgJkipGWiIxxgpHGguyqB8zkcgF6lmCHM1M09TQG_rmXvUh_iwaFfRpdoUc0ZaecQelpMfdzHlCnmpQ-AT8mjwY0Iz27PU_Ll3dvPuw_V-af3H3fb88orI3PVONO4oW10LZUYWN0NpXnQUCaCtmNScW48eO961yhoamM6b4xiQnaiF1rJU_L66Fs6_rYAZjsF9DCOboa4oBVa1LL4mLqgL_9CL-OS5tKdFTUzLW-FlnfUhRvBhnmIOTm_mtpt3ejy0ozzQp39gyqrhyn4OMMQyv09was_BHtwY95jHJf1P_A-KI6gTxExwWCvUphc-m45s2sc7DEOtsTB_oyDvSmiF7ejLd0E_W_Jr_8vgDwCWErzBaS72f9j-wPjwL6R</recordid><startdate>20211201</startdate><enddate>20211201</enddate><creator>Yang, Xingjin</creator><creator>Zhang, Dongdong</creator><creator>Zhao, Yang</creator><creator>Liu, Dechen</creator><creator>Li, Quanman</creator><creator>Guo, Chunmei</creator><creator>Tian, Gang</creator><creator>Han, Minghui</creator><creator>Qie, Ranran</creator><creator>Huang, Shengbing</creator><creator>Zhou, Qionggui</creator><creator>Feng, Yifei</creator><creator>Wu, Xiaoyan</creator><creator>Zhang, Yanyan</creator><creator>Li, Yang</creator><creator>Wu, Yuying</creator><creator>Cheng, Cheng</creator><creator>Hu, Dongsheng</creator><creator>Sun, Liang</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9998-8041</orcidid><orcidid>https://orcid.org/0000-0002-9795-3574</orcidid></search><sort><creationdate>20211201</creationdate><title>Association between serum level of C-reactive protein and risk of cardiovascular events based on cohort studies</title><author>Yang, Xingjin ; Zhang, Dongdong ; Zhao, Yang ; Liu, Dechen ; Li, Quanman ; Guo, Chunmei ; Tian, Gang ; Han, Minghui ; Qie, Ranran ; Huang, Shengbing ; Zhou, Qionggui ; Feng, Yifei ; Wu, Xiaoyan ; Zhang, Yanyan ; Li, Yang ; Wu, Yuying ; Cheng, Cheng ; Hu, Dongsheng ; Sun, Liang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473t-8a78af9856342f06bf001e5e095e9b034117ceccada84e8677bc774023b2d2543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>692/499</topic><topic>692/699/75</topic><topic>692/699/75/230</topic><topic>82</topic><topic>82/1</topic><topic>C-Reactive Protein</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Cardiovascular Diseases - diagnosis</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cohort analysis</topic><topic>Cohort Studies</topic><topic>Coronary artery disease</topic><topic>Diagnosis</topic><topic>Epidemiology</topic><topic>Health Administration</topic><topic>Health aspects</topic><topic>Heart diseases</topic><topic>Humans</topic><topic>Measurement</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Meta-analysis</topic><topic>Public Health</topic><topic>Regression analysis</topic><topic>Review Article</topic><topic>Risk assessment</topic><topic>Risk factors</topic><topic>Stroke</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Xingjin</creatorcontrib><creatorcontrib>Zhang, Dongdong</creatorcontrib><creatorcontrib>Zhao, Yang</creatorcontrib><creatorcontrib>Liu, Dechen</creatorcontrib><creatorcontrib>Li, Quanman</creatorcontrib><creatorcontrib>Guo, Chunmei</creatorcontrib><creatorcontrib>Tian, Gang</creatorcontrib><creatorcontrib>Han, Minghui</creatorcontrib><creatorcontrib>Qie, Ranran</creatorcontrib><creatorcontrib>Huang, Shengbing</creatorcontrib><creatorcontrib>Zhou, Qionggui</creatorcontrib><creatorcontrib>Feng, Yifei</creatorcontrib><creatorcontrib>Wu, Xiaoyan</creatorcontrib><creatorcontrib>Zhang, Yanyan</creatorcontrib><creatorcontrib>Li, Yang</creatorcontrib><creatorcontrib>Wu, Yuying</creatorcontrib><creatorcontrib>Cheng, Cheng</creatorcontrib><creatorcontrib>Hu, Dongsheng</creatorcontrib><creatorcontrib>Sun, Liang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of human hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Xingjin</au><au>Zhang, Dongdong</au><au>Zhao, Yang</au><au>Liu, Dechen</au><au>Li, Quanman</au><au>Guo, Chunmei</au><au>Tian, Gang</au><au>Han, Minghui</au><au>Qie, Ranran</au><au>Huang, Shengbing</au><au>Zhou, Qionggui</au><au>Feng, Yifei</au><au>Wu, Xiaoyan</au><au>Zhang, Yanyan</au><au>Li, Yang</au><au>Wu, Yuying</au><au>Cheng, Cheng</au><au>Hu, Dongsheng</au><au>Sun, Liang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between serum level of C-reactive protein and risk of cardiovascular events based on cohort studies</atitle><jtitle>Journal of human hypertension</jtitle><stitle>J Hum Hypertens</stitle><addtitle>J Hum Hypertens</addtitle><date>2021-12-01</date><risdate>2021</risdate><volume>35</volume><issue>12</issue><spage>1149</spage><epage>1158</epage><pages>1149-1158</pages><issn>0950-9240</issn><eissn>1476-5527</eissn><abstract>Although the association between serum level of C-reactive protein (CRP) and risk of cardiovascular events (CVEs) has been reported, the comprehensive assessment of the quantitative association of CRP level with risk of CVEs has not been reported. Our meta-analysis aims to quantitatively evaluate the association of CRP level and risk of CVEs. We searched PubMed and Embase databases for articles published up to December 6, 2019. Studies with data on men and women, different types of CVEs and multiple cohorts within a study were treated as independent studies. Generalized least-squares regression models were used to assess the quantitative association between CRP level and risk of CVEs. Restricted cubic splines were used to model the possible linear association between CRP and CVEs. We included 36 articles (60 studies; 227,715 participants) in the analysis. The pooled relative risks (RRs) of high versus low CRP level for cardiovascular disease (CVD), stroke and coronary heart disease (CHD) were 1.64 (95% confidence interval [CI], 1.49–1.82), 1.46 (95% CI, 1.35–1.58), and 1.55 (95% CI, 1.47–1.63), respectively. A linear association was found between CRP level and CVD (
P
= 0.429), stroke (
P
= 0.940), and CHD (
P
= 0.931); with each 1-mg/L increase in CRP level, the pooled RRs for CVD, stroke, and CHD were 1.18 (95% CI, 1.12–1.24), 1.07 (95% CI, 1.04–1.09), and 1.12 (95% CI, 1.08–1.16), respectively. This meta-analysis suggests that risk of CVEs increases with increasing serum CRP level.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>33980977</pmid><doi>10.1038/s41371-021-00546-z</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-9998-8041</orcidid><orcidid>https://orcid.org/0000-0002-9795-3574</orcidid></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of human hypertension, 2021-12, Vol.35 (12), p.1149-1158 |
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| subjects | 692/499 692/699/75 692/699/75/230 82 82/1 C-Reactive Protein Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - diagnosis Cardiovascular Diseases - epidemiology Cohort analysis Cohort Studies Coronary artery disease Diagnosis Epidemiology Health Administration Health aspects Heart diseases Humans Measurement Medicine Medicine & Public Health Meta-analysis Public Health Regression analysis Review Article Risk assessment Risk factors Stroke |
| title | Association between serum level of C-reactive protein and risk of cardiovascular events based on cohort studies |
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