Role of Microparticles in Cardiovascular Disease: Implications for Endothelial Dysfunction, Thrombosis, and Inflammation
Microparticles are small cell vesicles that are derived from the cell membrane in response to different biological processes. There is growing evidence supporting the association between microparticles and cardiovascular disease, as their pathophysiology commonly includes endothelial damage and chro...
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| Veröffentlicht in: | Hypertension (Dallas, Tex. 1979) Tex. 1979), 2021-06, Vol.77 (6), p.1825-1844 |
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| container_title | Hypertension (Dallas, Tex. 1979) |
| container_volume | 77 |
| creator | Lugo-Gavidia, Leslie Marisol Burger, Dylan Matthews, Vance B. Nolde, Janis M. Galindo Kiuchi, Márcio Carnagarin, Revathy Kannenkeril, Dennis Chan, Justine Joyson, Anu Herat, Lakshini Y. Azzam, Omar Schlaich, Markus P. |
| description | Microparticles are small cell vesicles that are derived from the cell membrane in response to different biological processes. There is growing evidence supporting the association between microparticles and cardiovascular disease, as their pathophysiology commonly includes endothelial damage and chronic inflammation which also promote a prothrombotic state. The direct causal link between the release of the different subtypes of microparticles and their implications on physiological and pathological conditions is still not completely elucidated. However, evidence suggests microparticles released from platelets, leukocytes, and endothelium may help to evaluate vascular health as they have a relevant role in inflammation, endothelial function, and thrombosis. This review aims to provide a short overview of the biogenesis, characteristics, and detection methodology of microparticles with a special focus on their possible implication in cardiovascular settings. |
| doi_str_mv | 10.1161/HYPERTENSIONAHA.121.16975 |
| format | Article |
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| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Atherosclerosis - physiopathology Cardiovascular Diseases - physiopathology Cell-Derived Microparticles - physiology Endothelium, Vascular - physiopathology Humans Inflammation - physiopathology Thrombosis - physiopathology |
| title | Role of Microparticles in Cardiovascular Disease: Implications for Endothelial Dysfunction, Thrombosis, and Inflammation |
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