Immobilization of cellulase on monolith supported with Zr(IV)-based metal-organic framework as chiral stationary phase for enantioseparation of five basic drugs in capillary electrochromatography
Metal-organic framework (UiO-66-NH 2 )-incorporated organic polymer monolith was prepared by thermal polymerization. By virtue of the superior physical and chemical properties, the UiO-66-NH 2 -modified organic monolith was then functionalized by chiral selector cellulase via the condensation reacti...
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| Veröffentlicht in: | Mikrochimica acta (1966) 2021-06, Vol.188 (6), p.186-186, Article 186 |
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| creator | Ma, Mingxuan Zhang, Jian Li, Peipei Du, Yingxiang Gan, Jie Yang, Jiangxia Zhang, Liu |
| description | Metal-organic framework (UiO-66-NH
2
)-incorporated organic polymer monolith was prepared by thermal polymerization. By virtue of the superior physical and chemical properties, the UiO-66-NH
2
-modified organic monolith was then functionalized by chiral selector cellulase via the condensation reaction between the primary amino groups and aldehyde groups. The synthesized materials were characterized by Fourier transform infrared spectroscopy, high-resolution transmission electron microscopy, scanning electron microscopy, X-ray photoelectron spectrometry, thermogravimetric analysis, and nitrogen sorption isotherm. The cellulase@poly(glycidyl methacrylate-UiO-66-NH
2
-ethylene glycol dimethacrylate) (cellulase@poly(GMA-UiO-66-NH
2
-EDMA)) monolith was applied to enantiomerically separate the basic racemic forms of metoprolol, atenolol, esmolol, bisoprolol, and propranolol. In contrast to the cellulase@poly(GMA-co-EDMA) monolith without UiO-66-NH
2
, the cellulase@poly(GMA-UiO-66-NH
2
-EDMA) monolith reveals significantly improved enantiodiscrimination performance for metoprolol (Rs: 0 → 1.67), atenolol (Rs: 0 → 1.50), esmolol (Rs: 0 → 1.52), bisoprolol (Rs: 0 → 0.36), and propranolol (Rs: 0 → 0.44). The immobilization pH of cellulase, buffer pH, UiO-66-NH
2
concentration, and the proportion of organic modifier were evaluated in detail with enantiomerically separating chiral molecules. The intra-day, inter-day, column-to-column, and inter-batch precision have been discussed, the result was preferable, and the relative standard deviation (RSD) of separation parameters was |
| doi_str_mv | 10.1007/s00604-021-04840-y |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2526136725</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A715056514</galeid><sourcerecordid>A715056514</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-78aadd1d73987852bb258547bf3b54d74041a2d18e7e933f075f321f74d1b4543</originalsourceid><addsrcrecordid>eNp9ks1u1DAUhSMEokPhBVggS2zKIsW_cWZZVfyMVIkNsGBjOfH1jItjBzuhGl6PF8OZKa1ACHlh-fo759pXp6qeE3xOMJavM8YN5jWmpMa85bjeP6hWhLOmFliyh9UKY9rUrJH0pHqS8zXGRDaUP65OGFvLtuVsVf3cDEPsnHc_9ORiQNGiHryfvc6AynmIIXo37VCexzGmCQy6WY5f0tnm86u6K5hBA0za1zFtdXA9skkPcBPTV6Qz6ncuaY_ydLDXaY_G3WJtY0IQdCjVDKNOd92t-w6o2BYjk-ZtRi6gXo_O-0UMHvopxX6X4qCnuE163O2fVo-s9hme3e6n1ae3bz5evq-vPrzbXF5c1T3ndKplq7UxxEi2bmUraNdR0QouO8s6wY3kmBNNDWlBwpoxi6WwjBIruSEdF5ydVmdH3zHFbzPkSQ0uL9PSAeKcFRW0Icu4RUFf_oVexzmF8roDxUjp3NxTW-1BuWDjlHS_mKoLSQQWjSBL2_N_UGUZGFwfA1hX6n8I6FHQp5hzAqvG5IYyPkWwWpKjjslRJTnqkBy1L6IXty-euwHMneR3VArAjkAuV2EL6f5L_7H9BbmY0c8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2526315856</pqid></control><display><type>article</type><title>Immobilization of cellulase on monolith supported with Zr(IV)-based metal-organic framework as chiral stationary phase for enantioseparation of five basic drugs in capillary electrochromatography</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Ma, Mingxuan ; Zhang, Jian ; Li, Peipei ; Du, Yingxiang ; Gan, Jie ; Yang, Jiangxia ; Zhang, Liu</creator><creatorcontrib>Ma, Mingxuan ; Zhang, Jian ; Li, Peipei ; Du, Yingxiang ; Gan, Jie ; Yang, Jiangxia ; Zhang, Liu</creatorcontrib><description>Metal-organic framework (UiO-66-NH
2
)-incorporated organic polymer monolith was prepared by thermal polymerization. By virtue of the superior physical and chemical properties, the UiO-66-NH
2
-modified organic monolith was then functionalized by chiral selector cellulase via the condensation reaction between the primary amino groups and aldehyde groups. The synthesized materials were characterized by Fourier transform infrared spectroscopy, high-resolution transmission electron microscopy, scanning electron microscopy, X-ray photoelectron spectrometry, thermogravimetric analysis, and nitrogen sorption isotherm. The cellulase@poly(glycidyl methacrylate-UiO-66-NH
2
-ethylene glycol dimethacrylate) (cellulase@poly(GMA-UiO-66-NH
2
-EDMA)) monolith was applied to enantiomerically separate the basic racemic forms of metoprolol, atenolol, esmolol, bisoprolol, and propranolol. In contrast to the cellulase@poly(GMA-co-EDMA) monolith without UiO-66-NH
2
, the cellulase@poly(GMA-UiO-66-NH
2
-EDMA) monolith reveals significantly improved enantiodiscrimination performance for metoprolol (Rs: 0 → 1.67), atenolol (Rs: 0 → 1.50), esmolol (Rs: 0 → 1.52), bisoprolol (Rs: 0 → 0.36), and propranolol (Rs: 0 → 0.44). The immobilization pH of cellulase, buffer pH, UiO-66-NH
2
concentration, and the proportion of organic modifier were evaluated in detail with enantiomerically separating chiral molecules. The intra-day, inter-day, column-to-column, and inter-batch precision have been discussed, the result was preferable, and the relative standard deviation (RSD) of separation parameters was <4.3%.
Graphical abstract
Schematic representation of the preparation of a UiO-66-NH
2
-modified organic polymer monolith for enantioseparating five racemic β-blockers. UiO-66-NH
2
was synthesized and converted into a monolith as the stationary phase. Then, the modified monolith containing cellulase as the chiral selector was applied in a capillary electrochromatography system for enantioseparating chiral drugs.</description><identifier>ISSN: 0026-3672</identifier><identifier>EISSN: 1436-5073</identifier><identifier>DOI: 10.1007/s00604-021-04840-y</identifier><identifier>PMID: 33978843</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Adrenergic beta blockers ; Adrenergic beta-1 Receptor Antagonists - chemistry ; Adrenergic beta-1 Receptor Antagonists - isolation & purification ; Aldehydes ; Analysis ; Analytical Chemistry ; Capillary Electrochromatography ; Cellulase ; Cellulase - chemistry ; Characterization and Evaluation of Materials ; Chemical properties ; Chemistry ; Chemistry and Materials Science ; Chromatography ; Degassing of metals ; Electrochromatography ; Enzymes, Immobilized - chemistry ; Ethylene glycol ; Fourier transforms ; Glycol dimethacrylates ; High resolution electron microscopy ; Hypocreales - enzymology ; Immobilization ; Infrared spectroscopy ; Metal-organic frameworks ; Metal-Organic Frameworks - chemistry ; Metals ; Methacrylates - chemistry ; Microengineering ; Microscopy ; Nanochemistry ; Nanotechnology ; Original Paper ; Phenoxypropanolamines - chemistry ; Phenoxypropanolamines - isolation & purification ; Photoelectrons ; Polymerization ; Polymethacrylic Acids - chemistry ; Stereoisomerism ; Thermogravimetric analysis ; Zirconium ; Zirconium - chemistry</subject><ispartof>Mikrochimica acta (1966), 2021-06, Vol.188 (6), p.186-186, Article 186</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature 2021</rights><rights>COPYRIGHT 2021 Springer</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-78aadd1d73987852bb258547bf3b54d74041a2d18e7e933f075f321f74d1b4543</citedby><cites>FETCH-LOGICAL-c442t-78aadd1d73987852bb258547bf3b54d74041a2d18e7e933f075f321f74d1b4543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00604-021-04840-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00604-021-04840-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33978843$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ma, Mingxuan</creatorcontrib><creatorcontrib>Zhang, Jian</creatorcontrib><creatorcontrib>Li, Peipei</creatorcontrib><creatorcontrib>Du, Yingxiang</creatorcontrib><creatorcontrib>Gan, Jie</creatorcontrib><creatorcontrib>Yang, Jiangxia</creatorcontrib><creatorcontrib>Zhang, Liu</creatorcontrib><title>Immobilization of cellulase on monolith supported with Zr(IV)-based metal-organic framework as chiral stationary phase for enantioseparation of five basic drugs in capillary electrochromatography</title><title>Mikrochimica acta (1966)</title><addtitle>Microchim Acta</addtitle><addtitle>Mikrochim Acta</addtitle><description>Metal-organic framework (UiO-66-NH
2
)-incorporated organic polymer monolith was prepared by thermal polymerization. By virtue of the superior physical and chemical properties, the UiO-66-NH
2
-modified organic monolith was then functionalized by chiral selector cellulase via the condensation reaction between the primary amino groups and aldehyde groups. The synthesized materials were characterized by Fourier transform infrared spectroscopy, high-resolution transmission electron microscopy, scanning electron microscopy, X-ray photoelectron spectrometry, thermogravimetric analysis, and nitrogen sorption isotherm. The cellulase@poly(glycidyl methacrylate-UiO-66-NH
2
-ethylene glycol dimethacrylate) (cellulase@poly(GMA-UiO-66-NH
2
-EDMA)) monolith was applied to enantiomerically separate the basic racemic forms of metoprolol, atenolol, esmolol, bisoprolol, and propranolol. In contrast to the cellulase@poly(GMA-co-EDMA) monolith without UiO-66-NH
2
, the cellulase@poly(GMA-UiO-66-NH
2
-EDMA) monolith reveals significantly improved enantiodiscrimination performance for metoprolol (Rs: 0 → 1.67), atenolol (Rs: 0 → 1.50), esmolol (Rs: 0 → 1.52), bisoprolol (Rs: 0 → 0.36), and propranolol (Rs: 0 → 0.44). The immobilization pH of cellulase, buffer pH, UiO-66-NH
2
concentration, and the proportion of organic modifier were evaluated in detail with enantiomerically separating chiral molecules. The intra-day, inter-day, column-to-column, and inter-batch precision have been discussed, the result was preferable, and the relative standard deviation (RSD) of separation parameters was <4.3%.
Graphical abstract
Schematic representation of the preparation of a UiO-66-NH
2
-modified organic polymer monolith for enantioseparating five racemic β-blockers. UiO-66-NH
2
was synthesized and converted into a monolith as the stationary phase. Then, the modified monolith containing cellulase as the chiral selector was applied in a capillary electrochromatography system for enantioseparating chiral drugs.</description><subject>Adrenergic beta blockers</subject><subject>Adrenergic beta-1 Receptor Antagonists - chemistry</subject><subject>Adrenergic beta-1 Receptor Antagonists - isolation & purification</subject><subject>Aldehydes</subject><subject>Analysis</subject><subject>Analytical Chemistry</subject><subject>Capillary Electrochromatography</subject><subject>Cellulase</subject><subject>Cellulase - chemistry</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemical properties</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chromatography</subject><subject>Degassing of metals</subject><subject>Electrochromatography</subject><subject>Enzymes, Immobilized - chemistry</subject><subject>Ethylene glycol</subject><subject>Fourier transforms</subject><subject>Glycol dimethacrylates</subject><subject>High resolution electron microscopy</subject><subject>Hypocreales - enzymology</subject><subject>Immobilization</subject><subject>Infrared spectroscopy</subject><subject>Metal-organic frameworks</subject><subject>Metal-Organic Frameworks - chemistry</subject><subject>Metals</subject><subject>Methacrylates - chemistry</subject><subject>Microengineering</subject><subject>Microscopy</subject><subject>Nanochemistry</subject><subject>Nanotechnology</subject><subject>Original Paper</subject><subject>Phenoxypropanolamines - chemistry</subject><subject>Phenoxypropanolamines - isolation & purification</subject><subject>Photoelectrons</subject><subject>Polymerization</subject><subject>Polymethacrylic Acids - chemistry</subject><subject>Stereoisomerism</subject><subject>Thermogravimetric analysis</subject><subject>Zirconium</subject><subject>Zirconium - chemistry</subject><issn>0026-3672</issn><issn>1436-5073</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9ks1u1DAUhSMEokPhBVggS2zKIsW_cWZZVfyMVIkNsGBjOfH1jItjBzuhGl6PF8OZKa1ACHlh-fo759pXp6qeE3xOMJavM8YN5jWmpMa85bjeP6hWhLOmFliyh9UKY9rUrJH0pHqS8zXGRDaUP65OGFvLtuVsVf3cDEPsnHc_9ORiQNGiHryfvc6AynmIIXo37VCexzGmCQy6WY5f0tnm86u6K5hBA0za1zFtdXA9skkPcBPTV6Qz6ncuaY_ydLDXaY_G3WJtY0IQdCjVDKNOd92t-w6o2BYjk-ZtRi6gXo_O-0UMHvopxX6X4qCnuE163O2fVo-s9hme3e6n1ae3bz5evq-vPrzbXF5c1T3ndKplq7UxxEi2bmUraNdR0QouO8s6wY3kmBNNDWlBwpoxi6WwjBIruSEdF5ydVmdH3zHFbzPkSQ0uL9PSAeKcFRW0Icu4RUFf_oVexzmF8roDxUjp3NxTW-1BuWDjlHS_mKoLSQQWjSBL2_N_UGUZGFwfA1hX6n8I6FHQp5hzAqvG5IYyPkWwWpKjjslRJTnqkBy1L6IXty-euwHMneR3VArAjkAuV2EL6f5L_7H9BbmY0c8</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Ma, Mingxuan</creator><creator>Zhang, Jian</creator><creator>Li, Peipei</creator><creator>Du, Yingxiang</creator><creator>Gan, Jie</creator><creator>Yang, Jiangxia</creator><creator>Zhang, Liu</creator><general>Springer Vienna</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20210601</creationdate><title>Immobilization of cellulase on monolith supported with Zr(IV)-based metal-organic framework as chiral stationary phase for enantioseparation of five basic drugs in capillary electrochromatography</title><author>Ma, Mingxuan ; Zhang, Jian ; Li, Peipei ; Du, Yingxiang ; Gan, Jie ; Yang, Jiangxia ; Zhang, Liu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-78aadd1d73987852bb258547bf3b54d74041a2d18e7e933f075f321f74d1b4543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adrenergic beta blockers</topic><topic>Adrenergic beta-1 Receptor Antagonists - chemistry</topic><topic>Adrenergic beta-1 Receptor Antagonists - isolation & purification</topic><topic>Aldehydes</topic><topic>Analysis</topic><topic>Analytical Chemistry</topic><topic>Capillary Electrochromatography</topic><topic>Cellulase</topic><topic>Cellulase - chemistry</topic><topic>Characterization and Evaluation of Materials</topic><topic>Chemical properties</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chromatography</topic><topic>Degassing of metals</topic><topic>Electrochromatography</topic><topic>Enzymes, Immobilized - chemistry</topic><topic>Ethylene glycol</topic><topic>Fourier transforms</topic><topic>Glycol dimethacrylates</topic><topic>High resolution electron microscopy</topic><topic>Hypocreales - enzymology</topic><topic>Immobilization</topic><topic>Infrared spectroscopy</topic><topic>Metal-organic frameworks</topic><topic>Metal-Organic Frameworks - chemistry</topic><topic>Metals</topic><topic>Methacrylates - chemistry</topic><topic>Microengineering</topic><topic>Microscopy</topic><topic>Nanochemistry</topic><topic>Nanotechnology</topic><topic>Original Paper</topic><topic>Phenoxypropanolamines - chemistry</topic><topic>Phenoxypropanolamines - isolation & purification</topic><topic>Photoelectrons</topic><topic>Polymerization</topic><topic>Polymethacrylic Acids - chemistry</topic><topic>Stereoisomerism</topic><topic>Thermogravimetric analysis</topic><topic>Zirconium</topic><topic>Zirconium - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ma, Mingxuan</creatorcontrib><creatorcontrib>Zhang, Jian</creatorcontrib><creatorcontrib>Li, Peipei</creatorcontrib><creatorcontrib>Du, Yingxiang</creatorcontrib><creatorcontrib>Gan, Jie</creatorcontrib><creatorcontrib>Yang, Jiangxia</creatorcontrib><creatorcontrib>Zhang, Liu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Mikrochimica acta (1966)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ma, Mingxuan</au><au>Zhang, Jian</au><au>Li, Peipei</au><au>Du, Yingxiang</au><au>Gan, Jie</au><au>Yang, Jiangxia</au><au>Zhang, Liu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immobilization of cellulase on monolith supported with Zr(IV)-based metal-organic framework as chiral stationary phase for enantioseparation of five basic drugs in capillary electrochromatography</atitle><jtitle>Mikrochimica acta (1966)</jtitle><stitle>Microchim Acta</stitle><addtitle>Mikrochim Acta</addtitle><date>2021-06-01</date><risdate>2021</risdate><volume>188</volume><issue>6</issue><spage>186</spage><epage>186</epage><pages>186-186</pages><artnum>186</artnum><issn>0026-3672</issn><eissn>1436-5073</eissn><abstract>Metal-organic framework (UiO-66-NH
2
)-incorporated organic polymer monolith was prepared by thermal polymerization. By virtue of the superior physical and chemical properties, the UiO-66-NH
2
-modified organic monolith was then functionalized by chiral selector cellulase via the condensation reaction between the primary amino groups and aldehyde groups. The synthesized materials were characterized by Fourier transform infrared spectroscopy, high-resolution transmission electron microscopy, scanning electron microscopy, X-ray photoelectron spectrometry, thermogravimetric analysis, and nitrogen sorption isotherm. The cellulase@poly(glycidyl methacrylate-UiO-66-NH
2
-ethylene glycol dimethacrylate) (cellulase@poly(GMA-UiO-66-NH
2
-EDMA)) monolith was applied to enantiomerically separate the basic racemic forms of metoprolol, atenolol, esmolol, bisoprolol, and propranolol. In contrast to the cellulase@poly(GMA-co-EDMA) monolith without UiO-66-NH
2
, the cellulase@poly(GMA-UiO-66-NH
2
-EDMA) monolith reveals significantly improved enantiodiscrimination performance for metoprolol (Rs: 0 → 1.67), atenolol (Rs: 0 → 1.50), esmolol (Rs: 0 → 1.52), bisoprolol (Rs: 0 → 0.36), and propranolol (Rs: 0 → 0.44). The immobilization pH of cellulase, buffer pH, UiO-66-NH
2
concentration, and the proportion of organic modifier were evaluated in detail with enantiomerically separating chiral molecules. The intra-day, inter-day, column-to-column, and inter-batch precision have been discussed, the result was preferable, and the relative standard deviation (RSD) of separation parameters was <4.3%.
Graphical abstract
Schematic representation of the preparation of a UiO-66-NH
2
-modified organic polymer monolith for enantioseparating five racemic β-blockers. UiO-66-NH
2
was synthesized and converted into a monolith as the stationary phase. Then, the modified monolith containing cellulase as the chiral selector was applied in a capillary electrochromatography system for enantioseparating chiral drugs.</abstract><cop>Vienna</cop><pub>Springer Vienna</pub><pmid>33978843</pmid><doi>10.1007/s00604-021-04840-y</doi><tpages>1</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0026-3672 |
| ispartof | Mikrochimica acta (1966), 2021-06, Vol.188 (6), p.186-186, Article 186 |
| issn | 0026-3672 1436-5073 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2526136725 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adrenergic beta blockers Adrenergic beta-1 Receptor Antagonists - chemistry Adrenergic beta-1 Receptor Antagonists - isolation & purification Aldehydes Analysis Analytical Chemistry Capillary Electrochromatography Cellulase Cellulase - chemistry Characterization and Evaluation of Materials Chemical properties Chemistry Chemistry and Materials Science Chromatography Degassing of metals Electrochromatography Enzymes, Immobilized - chemistry Ethylene glycol Fourier transforms Glycol dimethacrylates High resolution electron microscopy Hypocreales - enzymology Immobilization Infrared spectroscopy Metal-organic frameworks Metal-Organic Frameworks - chemistry Metals Methacrylates - chemistry Microengineering Microscopy Nanochemistry Nanotechnology Original Paper Phenoxypropanolamines - chemistry Phenoxypropanolamines - isolation & purification Photoelectrons Polymerization Polymethacrylic Acids - chemistry Stereoisomerism Thermogravimetric analysis Zirconium Zirconium - chemistry |
| title | Immobilization of cellulase on monolith supported with Zr(IV)-based metal-organic framework as chiral stationary phase for enantioseparation of five basic drugs in capillary electrochromatography |
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