Melatonin can be, more effective than N-acetylcysteine, protecting acute lung injury induced by intestinal ischemia-reperfusion in rat model
The current study compared the impact of pretreatment with melatonin and N-acetylcysteine (NAC) on the prevention of rat lung damage following intestinal ischemia-reperfusion (iIR). Twenty-eight Wistar rats were subjected to intestinal ischemia induced by a 60 min occlusion of the superior mesenteri...
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| container_title | Clinics (São Paulo, Brazil) |
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| creator | Leite, Alberto Andrade Reiter, Russel Joseph Brandão, Julio Cezar Mendes Sakae, Thiago Mamoru Marinho, Marcia Camargo, Celia Regina Oliveira-Junior, Itamar Souza |
| description | The current study compared the impact of pretreatment with melatonin and N-acetylcysteine (NAC) on the prevention of rat lung damage following intestinal ischemia-reperfusion (iIR).
Twenty-eight Wistar rats were subjected to intestinal ischemia induced by a 60 min occlusion of the superior mesenteric artery, followed by reperfusion for 120 min. Animals were divided into the following groups (n=7 per group): sham, only abdominal incision; SS+iIR, pretreated with saline solution and iIR; NAC+iIR, pretreated with NAC (20 mg/kg) and iIR; MEL+iIR, pretreated with melatonin (20 mg/kg) and iIR. Oxidative stress and inflammatory mediators were measured and histological analyses were performed in the lung tissues.
Data showed a reduction in malondialdehyde (MDA), myeloperoxidase (MPO), and TNF-alpha in the animals pretreated with NAC or MEL when compared to those treated with SS+iIR (p |
| doi_str_mv | 10.6061/clinics/2021/e2513 |
| format | Article |
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Twenty-eight Wistar rats were subjected to intestinal ischemia induced by a 60 min occlusion of the superior mesenteric artery, followed by reperfusion for 120 min. Animals were divided into the following groups (n=7 per group): sham, only abdominal incision; SS+iIR, pretreated with saline solution and iIR; NAC+iIR, pretreated with NAC (20 mg/kg) and iIR; MEL+iIR, pretreated with melatonin (20 mg/kg) and iIR. Oxidative stress and inflammatory mediators were measured and histological analyses were performed in the lung tissues.
Data showed a reduction in malondialdehyde (MDA), myeloperoxidase (MPO), and TNF-alpha in the animals pretreated with NAC or MEL when compared to those treated with SS+iIR (p<0.05). An increase in superoxide dismutase (SOD) levels in the NAC- and MEL-pretreated animals as compared to the SS+iIR group (34±8 U/g of tissue; p<0.05) was also observed. TNF-α levels were lower in the MEL+iIR group (91±5 pg/mL) than in the NAC+iIR group (101±6 pg/mL). Histological analysis demonstrated a higher lung lesion score in the SS+iIR group than in the pretreated groups.
Both agents individually provided tissue protective effect against intestinal IR-induced lung injury, but melatonin was more effective in ameliorating the parameters analyzed in this study.</description><identifier>ISSN: 1807-5932</identifier><identifier>ISSN: 1980-5322</identifier><identifier>EISSN: 1980-5322</identifier><identifier>DOI: 10.6061/clinics/2021/e2513</identifier><identifier>PMID: 33978073</identifier><language>eng</language><publisher>MADRID: Elsevier España, S.L.U</publisher><subject>Acute Respiratory Distress Syndrome ; Experimental Model ; General & Internal Medicine ; Intestinal Ischemia-Reperfusion ; Life Sciences & Biomedicine ; MEDICINE, GENERAL & INTERNAL ; Melatonin ; NAC ; Original ; Science & Technology</subject><ispartof>Clinics (São Paulo, Brazil), 2021-01, Vol.76, p.e2513-e2513, Article e2513</ispartof><rights>2021 CLINICS</rights><rights>Copyright © 2021 CLINICS 2021</rights><rights>This work is licensed under a Creative Commons Attribution 4.0 International License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>0</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000651623600001</woscitedreferencesoriginalsourcerecordid><cites>FETCH-LOGICAL-c511t-d585a7c87727337b7a0e9ce570d002ebf248f722a11fdd8e9e9a040781a6c2e3</cites><orcidid>0000-0001-6763-4225 ; 0000-0002-0603-3685 ; 0000-0003-0849-9734 ; 0000-0001-9621-2566 ; 0000-0001-5620-7295 ; 0000-0003-2177-6214 ; 0000-0001-5085-1389</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8075110/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8075110/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,2104,2116,27931,27932,39265,53798,53800</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33978073$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leite, Alberto Andrade</creatorcontrib><creatorcontrib>Reiter, Russel Joseph</creatorcontrib><creatorcontrib>Brandão, Julio Cezar Mendes</creatorcontrib><creatorcontrib>Sakae, Thiago Mamoru</creatorcontrib><creatorcontrib>Marinho, Marcia</creatorcontrib><creatorcontrib>Camargo, Celia Regina</creatorcontrib><creatorcontrib>Oliveira-Junior, Itamar Souza</creatorcontrib><title>Melatonin can be, more effective than N-acetylcysteine, protecting acute lung injury induced by intestinal ischemia-reperfusion in rat model</title><title>Clinics (São Paulo, Brazil)</title><addtitle>CLINICS</addtitle><addtitle>Clinics (Sao Paulo)</addtitle><description>The current study compared the impact of pretreatment with melatonin and N-acetylcysteine (NAC) on the prevention of rat lung damage following intestinal ischemia-reperfusion (iIR).
Twenty-eight Wistar rats were subjected to intestinal ischemia induced by a 60 min occlusion of the superior mesenteric artery, followed by reperfusion for 120 min. Animals were divided into the following groups (n=7 per group): sham, only abdominal incision; SS+iIR, pretreated with saline solution and iIR; NAC+iIR, pretreated with NAC (20 mg/kg) and iIR; MEL+iIR, pretreated with melatonin (20 mg/kg) and iIR. Oxidative stress and inflammatory mediators were measured and histological analyses were performed in the lung tissues.
Data showed a reduction in malondialdehyde (MDA), myeloperoxidase (MPO), and TNF-alpha in the animals pretreated with NAC or MEL when compared to those treated with SS+iIR (p<0.05). An increase in superoxide dismutase (SOD) levels in the NAC- and MEL-pretreated animals as compared to the SS+iIR group (34±8 U/g of tissue; p<0.05) was also observed. TNF-α levels were lower in the MEL+iIR group (91±5 pg/mL) than in the NAC+iIR group (101±6 pg/mL). Histological analysis demonstrated a higher lung lesion score in the SS+iIR group than in the pretreated groups.
Both agents individually provided tissue protective effect against intestinal IR-induced lung injury, but melatonin was more effective in ameliorating the parameters analyzed in this study.</description><subject>Acute Respiratory Distress Syndrome</subject><subject>Experimental Model</subject><subject>General & Internal Medicine</subject><subject>Intestinal Ischemia-Reperfusion</subject><subject>Life Sciences & Biomedicine</subject><subject>MEDICINE, GENERAL & INTERNAL</subject><subject>Melatonin</subject><subject>NAC</subject><subject>Original</subject><subject>Science & Technology</subject><issn>1807-5932</issn><issn>1980-5322</issn><issn>1980-5322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>DOA</sourceid><recordid>eNqNUstuEzEUHSEQLYUfYIFmiQTT-jGeh4QqoYhHpQILurc89nXiaGIH2xOUf-CjudOEiG4QC8tXvucc38cpipeUXDakoVd6dN7pdMUIo1fABOWPinPad6QSnLHHGHekrUTP2VnxLKU1IbzntXhanHHet5jj58WvLzCqHLzzpVa-HOBtuQkRSrAWdHY7KPMK379WSkPej3qfMjiPqG0MeUb4Zan0lKEcJwydX09xj5eZNJhymMMMCWFqLF3SK9g4VUXYQrRTcsFjvowq46cGxufFE6vGBC-O90Vx9_HD3eJzdfvt083i_W2lBaW5MqITqtVd27KW83ZoFYFeg2iJIYTBYFnd2ZYxRak1poMeekVq0nZUNZoBvyhuDrImqLXcRrdRcS-DcvL-IcSlVDE7PYJsaMd1TUG3dqhrKvpBGCDMUmHrmoFBrcuDVtIOxiDXYYrYa5Lf5-HLefjzeggheFjTIOH6QNhOwwaMBp-jGh9U8TDj3Uouw06iHHZPUOD1USCGHxPOVm5wsDCOykOYkmSCNZQ3uF2EsgNUx5BSBHv6hhI5W0geLSTnGuW9hZD06u8CT5Q_nkHAmwPgJwzBzn17DScYdtoI2jCsYG4a0d3_oxcuq4yuWITJZ6S-O1ABvbBzEOWRblxE6-G23L8a-Q30w_pf</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Leite, Alberto Andrade</creator><creator>Reiter, Russel Joseph</creator><creator>Brandão, Julio Cezar Mendes</creator><creator>Sakae, Thiago Mamoru</creator><creator>Marinho, Marcia</creator><creator>Camargo, Celia Regina</creator><creator>Oliveira-Junior, Itamar Souza</creator><general>Elsevier España, S.L.U</general><general>Elsevier</general><general>Faculdade de Medicina / USP</general><general>Elsevier España</general><scope>6I.</scope><scope>AAFTH</scope><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>GPN</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-6763-4225</orcidid><orcidid>https://orcid.org/0000-0002-0603-3685</orcidid><orcidid>https://orcid.org/0000-0003-0849-9734</orcidid><orcidid>https://orcid.org/0000-0001-9621-2566</orcidid><orcidid>https://orcid.org/0000-0001-5620-7295</orcidid><orcidid>https://orcid.org/0000-0003-2177-6214</orcidid><orcidid>https://orcid.org/0000-0001-5085-1389</orcidid></search><sort><creationdate>20210101</creationdate><title>Melatonin can be, more effective than N-acetylcysteine, protecting acute lung injury induced by intestinal ischemia-reperfusion in rat model</title><author>Leite, Alberto Andrade ; Reiter, Russel Joseph ; Brandão, Julio Cezar Mendes ; Sakae, Thiago Mamoru ; Marinho, Marcia ; Camargo, Celia Regina ; Oliveira-Junior, Itamar Souza</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-d585a7c87727337b7a0e9ce570d002ebf248f722a11fdd8e9e9a040781a6c2e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acute Respiratory Distress Syndrome</topic><topic>Experimental Model</topic><topic>General & Internal Medicine</topic><topic>Intestinal Ischemia-Reperfusion</topic><topic>Life Sciences & Biomedicine</topic><topic>MEDICINE, GENERAL & INTERNAL</topic><topic>Melatonin</topic><topic>NAC</topic><topic>Original</topic><topic>Science & Technology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leite, Alberto Andrade</creatorcontrib><creatorcontrib>Reiter, Russel Joseph</creatorcontrib><creatorcontrib>Brandão, Julio Cezar Mendes</creatorcontrib><creatorcontrib>Sakae, Thiago Mamoru</creatorcontrib><creatorcontrib>Marinho, Marcia</creatorcontrib><creatorcontrib>Camargo, Celia Regina</creatorcontrib><creatorcontrib>Oliveira-Junior, Itamar Souza</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SciELO</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Clinics (São Paulo, Brazil)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leite, Alberto Andrade</au><au>Reiter, Russel Joseph</au><au>Brandão, Julio Cezar Mendes</au><au>Sakae, Thiago Mamoru</au><au>Marinho, Marcia</au><au>Camargo, Celia Regina</au><au>Oliveira-Junior, Itamar Souza</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Melatonin can be, more effective than N-acetylcysteine, protecting acute lung injury induced by intestinal ischemia-reperfusion in rat model</atitle><jtitle>Clinics (São Paulo, Brazil)</jtitle><stitle>CLINICS</stitle><addtitle>Clinics (Sao Paulo)</addtitle><date>2021-01-01</date><risdate>2021</risdate><volume>76</volume><spage>e2513</spage><epage>e2513</epage><pages>e2513-e2513</pages><artnum>e2513</artnum><artnum>2513</artnum><issn>1807-5932</issn><issn>1980-5322</issn><eissn>1980-5322</eissn><abstract>The current study compared the impact of pretreatment with melatonin and N-acetylcysteine (NAC) on the prevention of rat lung damage following intestinal ischemia-reperfusion (iIR).
Twenty-eight Wistar rats were subjected to intestinal ischemia induced by a 60 min occlusion of the superior mesenteric artery, followed by reperfusion for 120 min. Animals were divided into the following groups (n=7 per group): sham, only abdominal incision; SS+iIR, pretreated with saline solution and iIR; NAC+iIR, pretreated with NAC (20 mg/kg) and iIR; MEL+iIR, pretreated with melatonin (20 mg/kg) and iIR. Oxidative stress and inflammatory mediators were measured and histological analyses were performed in the lung tissues.
Data showed a reduction in malondialdehyde (MDA), myeloperoxidase (MPO), and TNF-alpha in the animals pretreated with NAC or MEL when compared to those treated with SS+iIR (p<0.05). An increase in superoxide dismutase (SOD) levels in the NAC- and MEL-pretreated animals as compared to the SS+iIR group (34±8 U/g of tissue; p<0.05) was also observed. TNF-α levels were lower in the MEL+iIR group (91±5 pg/mL) than in the NAC+iIR group (101±6 pg/mL). Histological analysis demonstrated a higher lung lesion score in the SS+iIR group than in the pretreated groups.
Both agents individually provided tissue protective effect against intestinal IR-induced lung injury, but melatonin was more effective in ameliorating the parameters analyzed in this study.</abstract><cop>MADRID</cop><pub>Elsevier España, S.L.U</pub><pmid>33978073</pmid><doi>10.6061/clinics/2021/e2513</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-6763-4225</orcidid><orcidid>https://orcid.org/0000-0002-0603-3685</orcidid><orcidid>https://orcid.org/0000-0003-0849-9734</orcidid><orcidid>https://orcid.org/0000-0001-9621-2566</orcidid><orcidid>https://orcid.org/0000-0001-5620-7295</orcidid><orcidid>https://orcid.org/0000-0003-2177-6214</orcidid><orcidid>https://orcid.org/0000-0001-5085-1389</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acute Respiratory Distress Syndrome Experimental Model General & Internal Medicine Intestinal Ischemia-Reperfusion Life Sciences & Biomedicine MEDICINE, GENERAL & INTERNAL Melatonin NAC Original Science & Technology |
| title | Melatonin can be, more effective than N-acetylcysteine, protecting acute lung injury induced by intestinal ischemia-reperfusion in rat model |
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