Bilateral diffuse uveal melanocytic proliferation with multifocal diffuse integumentary melanocytic proliferation paraneoplastic syndrome: A case report
Bilateral diffuse uveal melanocytic proliferation (B‐DUMP) is a rare paraneoplastic syndrome typically presenting with bilateral visual loss. B‐DUMP is associated with extraocular systemic malignancies with the most common being lung cancer in males and uro‐gynaecological cancer in females (mainly o...
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Veröffentlicht in: | Australasian journal of dermatology 2021-08, Vol.62 (3), p.386-389 |
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creator | Navarrete‐Dechent, Cristián Monnier, Jilliana Marghoob, Nadeem G Liopyris, Konstantinos Busam, Klaus J Francis, Jasmine H Marghoob, Ashfaq A |
description | Bilateral diffuse uveal melanocytic proliferation (B‐DUMP) is a rare paraneoplastic syndrome typically presenting with bilateral visual loss. B‐DUMP is associated with extraocular systemic malignancies with the most common being lung cancer in males and uro‐gynaecological cancer in females (mainly ovarian cancer). Cutaneous and/or mucosal involvement in patients with B‐DUMP has been reported but it is not well characterised. Herein, we present a female in her 70s with diagnosis of stage IV vaginal clear‐cell carcinoma and metastatic melanoma of unknown primary that developed progressive bilateral loss of visual acuity compatible with ‘B‐DUMP’. Simultaneously, she developed multifocal bilateral bluish‐greyish patches on the skin that were shown to have a proliferation of dermal melanocytes. We propose that the clinical and histopathologic cutaneous findings seen in patients with B‐DUMP be termed ‘diffuse integumentary melanocytic proliferation (DIMP)’. |
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B‐DUMP is associated with extraocular systemic malignancies with the most common being lung cancer in males and uro‐gynaecological cancer in females (mainly ovarian cancer). Cutaneous and/or mucosal involvement in patients with B‐DUMP has been reported but it is not well characterised. Herein, we present a female in her 70s with diagnosis of stage IV vaginal clear‐cell carcinoma and metastatic melanoma of unknown primary that developed progressive bilateral loss of visual acuity compatible with ‘B‐DUMP’. Simultaneously, she developed multifocal bilateral bluish‐greyish patches on the skin that were shown to have a proliferation of dermal melanocytes. We propose that the clinical and histopathologic cutaneous findings seen in patients with B‐DUMP be termed ‘diffuse integumentary melanocytic proliferation (DIMP)’.</description><identifier>ISSN: 0004-8380</identifier><identifier>EISSN: 1440-0960</identifier><identifier>DOI: 10.1111/ajd.13617</identifier><identifier>PMID: 33974277</identifier><language>eng</language><publisher>Australia: Wiley Subscription Services, Inc</publisher><subject>Acuity ; Adenocarcinoma, Clear Cell - complications ; Adenocarcinoma, Clear Cell - pathology ; Aged ; bilateral diffuse uveal melanocytic proliferation ; Cancer ; Case reports ; dermatology ; Female ; Humans ; Lung cancer ; Melanocytes ; Melanoma ; Metastases ; Mucosa ; ocular ; Ovarian cancer ; Paraneoplastic syndrome ; Paraneoplastic Syndromes, Ocular - complications ; Paraneoplastic Syndromes, Ocular - pathology ; Patients ; Uvea - pathology ; Vagina ; Vaginal Neoplasms - complications ; Vaginal Neoplasms - pathology</subject><ispartof>Australasian journal of dermatology, 2021-08, Vol.62 (3), p.386-389</ispartof><rights>2021 The Australasian College of Dermatologists</rights><rights>2021 The Australasian College of Dermatologists.</rights><rights>Copyright © 2021 The Australasian College of Dermatologists</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3487-b3854b7d8828642f4d83bb7b12597f77cd739c0e2bdef3f964140a9afc3316f93</cites><orcidid>0000-0003-4040-3640 ; 0000-0003-0888-9601 ; 0000-0002-8747-5011 ; 0000-0001-9566-8238 ; 0000-0001-6068-0114 ; 0000-0002-7637-3108</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fajd.13617$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fajd.13617$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33974277$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Navarrete‐Dechent, Cristián</creatorcontrib><creatorcontrib>Monnier, Jilliana</creatorcontrib><creatorcontrib>Marghoob, Nadeem G</creatorcontrib><creatorcontrib>Liopyris, Konstantinos</creatorcontrib><creatorcontrib>Busam, Klaus J</creatorcontrib><creatorcontrib>Francis, Jasmine H</creatorcontrib><creatorcontrib>Marghoob, Ashfaq A</creatorcontrib><title>Bilateral diffuse uveal melanocytic proliferation with multifocal diffuse integumentary melanocytic proliferation paraneoplastic syndrome: A case report</title><title>Australasian journal of dermatology</title><addtitle>Australas J Dermatol</addtitle><description>Bilateral diffuse uveal melanocytic proliferation (B‐DUMP) is a rare paraneoplastic syndrome typically presenting with bilateral visual loss. B‐DUMP is associated with extraocular systemic malignancies with the most common being lung cancer in males and uro‐gynaecological cancer in females (mainly ovarian cancer). Cutaneous and/or mucosal involvement in patients with B‐DUMP has been reported but it is not well characterised. Herein, we present a female in her 70s with diagnosis of stage IV vaginal clear‐cell carcinoma and metastatic melanoma of unknown primary that developed progressive bilateral loss of visual acuity compatible with ‘B‐DUMP’. Simultaneously, she developed multifocal bilateral bluish‐greyish patches on the skin that were shown to have a proliferation of dermal melanocytes. 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B‐DUMP is associated with extraocular systemic malignancies with the most common being lung cancer in males and uro‐gynaecological cancer in females (mainly ovarian cancer). Cutaneous and/or mucosal involvement in patients with B‐DUMP has been reported but it is not well characterised. Herein, we present a female in her 70s with diagnosis of stage IV vaginal clear‐cell carcinoma and metastatic melanoma of unknown primary that developed progressive bilateral loss of visual acuity compatible with ‘B‐DUMP’. Simultaneously, she developed multifocal bilateral bluish‐greyish patches on the skin that were shown to have a proliferation of dermal melanocytes. 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subjects | Acuity Adenocarcinoma, Clear Cell - complications Adenocarcinoma, Clear Cell - pathology Aged bilateral diffuse uveal melanocytic proliferation Cancer Case reports dermatology Female Humans Lung cancer Melanocytes Melanoma Metastases Mucosa ocular Ovarian cancer Paraneoplastic syndrome Paraneoplastic Syndromes, Ocular - complications Paraneoplastic Syndromes, Ocular - pathology Patients Uvea - pathology Vagina Vaginal Neoplasms - complications Vaginal Neoplasms - pathology |
title | Bilateral diffuse uveal melanocytic proliferation with multifocal diffuse integumentary melanocytic proliferation paraneoplastic syndrome: A case report |
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