Bilateral diffuse uveal melanocytic proliferation with multifocal diffuse integumentary melanocytic proliferation paraneoplastic syndrome: A case report

Bilateral diffuse uveal melanocytic proliferation (B‐DUMP) is a rare paraneoplastic syndrome typically presenting with bilateral visual loss. B‐DUMP is associated with extraocular systemic malignancies with the most common being lung cancer in males and uro‐gynaecological cancer in females (mainly o...

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Veröffentlicht in:Australasian journal of dermatology 2021-08, Vol.62 (3), p.386-389
Hauptverfasser: Navarrete‐Dechent, Cristián, Monnier, Jilliana, Marghoob, Nadeem G, Liopyris, Konstantinos, Busam, Klaus J, Francis, Jasmine H, Marghoob, Ashfaq A
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container_title Australasian journal of dermatology
container_volume 62
creator Navarrete‐Dechent, Cristián
Monnier, Jilliana
Marghoob, Nadeem G
Liopyris, Konstantinos
Busam, Klaus J
Francis, Jasmine H
Marghoob, Ashfaq A
description Bilateral diffuse uveal melanocytic proliferation (B‐DUMP) is a rare paraneoplastic syndrome typically presenting with bilateral visual loss. B‐DUMP is associated with extraocular systemic malignancies with the most common being lung cancer in males and uro‐gynaecological cancer in females (mainly ovarian cancer). Cutaneous and/or mucosal involvement in patients with B‐DUMP has been reported but it is not well characterised. Herein, we present a female in her 70s with diagnosis of stage IV vaginal clear‐cell carcinoma and metastatic melanoma of unknown primary that developed progressive bilateral loss of visual acuity compatible with ‘B‐DUMP’. Simultaneously, she developed multifocal bilateral bluish‐greyish patches on the skin that were shown to have a proliferation of dermal melanocytes. We propose that the clinical and histopathologic cutaneous findings seen in patients with B‐DUMP be termed ‘diffuse integumentary melanocytic proliferation (DIMP)’.
doi_str_mv 10.1111/ajd.13617
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subjects Acuity
Adenocarcinoma, Clear Cell - complications
Adenocarcinoma, Clear Cell - pathology
Aged
bilateral diffuse uveal melanocytic proliferation
Cancer
Case reports
dermatology
Female
Humans
Lung cancer
Melanocytes
Melanoma
Metastases
Mucosa
ocular
Ovarian cancer
Paraneoplastic syndrome
Paraneoplastic Syndromes, Ocular - complications
Paraneoplastic Syndromes, Ocular - pathology
Patients
Uvea - pathology
Vagina
Vaginal Neoplasms - complications
Vaginal Neoplasms - pathology
title Bilateral diffuse uveal melanocytic proliferation with multifocal diffuse integumentary melanocytic proliferation paraneoplastic syndrome: A case report
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