Efficacy and acceptability of noninvasive brain stimulation interventions for weight reduction in obesity: a pilot network meta-analysis
Background/Objectives: Obesity has recently been recognized as a neurocognitive disorder involving circuits associated with the reward system and the dorsolateral prefrontal cortex (DLPFC). Noninvasive brain stimulation (NIBS) has been proposed as a strategy for the management of obesity. However, t...
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| Veröffentlicht in: | International Journal of Obesity 2021-08, Vol.45 (8), p.1705-1716 |
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| container_title | International Journal of Obesity |
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| creator | Zeng, Bing-Yan Zeng, Bing-Syuan Chen, Yen-Wen Hung, Chao-Ming Sun, Cheuk-Kwan Cheng, Yu-Shian Stubbs, Brendon Carvalho, Andre F. Brunoni, Andre R. Su, Kuan-Pin Tu, Yu-Kang Wu, Yi-Cheng Chen, Tien-Yu Lin, Pao-Yen Liang, Chih-Sung Hsu, Chih-Wei Tseng, Ping-Tao Li, Cheng-Ta |
| description | Background/Objectives:
Obesity has recently been recognized as a neurocognitive disorder involving circuits associated with the reward system and the dorsolateral prefrontal cortex (DLPFC). Noninvasive brain stimulation (NIBS) has been proposed as a strategy for the management of obesity. However, the results have been inconclusive. The aim of the current network meta-analysis (NMA) was to evaluate the efficacy and acceptability of different NIBS modalities for weight reduction in participants with obesity.
Methods:
Randomized controlled trials (RCTs) examining NIBS interventions in patients with obesity were analyzed using the frequentist model of NMA. The coprimary outcome was change in body mass index (BMI) and acceptability, which was calculated using the dropout rate.
Results:
Overall, the current NMA, consisting of eight RCTs, revealed that the high-frequency repetitive transcranial magnetic stimulation (TMS) over the left DLPFC was ranked to be associated with the second-largest decrease in BMI and the largest decrease in total energy intake and craving severity, whereas the high-frequency deep TMS over bilateral DLPFC and the insula was ranked to be associated with the largest decrease in BMI.
Conclusion:
This pilot study provided a “signal” for the design of more methodologically robust and larger RCTs based on the findings of the potentially beneficial effect on weight reduction in participants with obesity by different NIBS interventions. |
| doi_str_mv | 10.1038/s41366-021-00833-2 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2525653540</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A669615440</galeid><sourcerecordid>A669615440</sourcerecordid><originalsourceid>FETCH-LOGICAL-c539t-20be4043db67c644b805a68d41450ff175076141624a512a2ccd886d9625301f3</originalsourceid><addsrcrecordid>eNp9kl1rFDEUhoModlv9A15IQCjeTM33zHhXSq1CwRu9DpnMyW7qTLImmS37D_zZzn5orYjk4pCc533JObwIvaLkghLevMuCcqUqwmhFSMN5xZ6gBRW1qqRo66doQTipKyKVPEGnOd8RQqQk7Dk64bytmWrrBfpx7Zy3xm6xCT021sK6mM4PvmxxdDjE4MPGZL8B3CXjA87Fj9Ngio8B-1AgbSDsLhm7mPA9-OWq4AT9ZI8Ijh3k2e49Nnjth1hwgHIf0zc8QjGVCWbYZp9foGfODBleHusZ-vrh-svVx-r2882nq8vbykreloqRDgQRvO9UbZUQXUOkUU0vqJDEOVpLUisqqGLCSMoMs7ZvGtW3iklOqONn6O3Bd53i9wly0aPPFobBBIhT1kyyeWFcCjKjb_5C7-KU5v_uKCmaVhHKH6ilGUD74GJJxu5M9aVSraJS7L0u_kHNp4fR2xjA-fn9keD8D8EKzFBWOQ7TftePQXYAbYo5J3B6nfxo0lZTonc50Yec6Dknep8TzWbR6-NoUzdC_1vyKxgzwA9AnlthCelh9v_Y_gQ0osco</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2554896013</pqid></control><display><type>article</type><title>Efficacy and acceptability of noninvasive brain stimulation interventions for weight reduction in obesity: a pilot network meta-analysis</title><source>MEDLINE</source><source>Nature Journals Online</source><source>SpringerLink Journals - AutoHoldings</source><creator>Zeng, Bing-Yan ; Zeng, Bing-Syuan ; Chen, Yen-Wen ; Hung, Chao-Ming ; Sun, Cheuk-Kwan ; Cheng, Yu-Shian ; Stubbs, Brendon ; Carvalho, Andre F. ; Brunoni, Andre R. ; Su, Kuan-Pin ; Tu, Yu-Kang ; Wu, Yi-Cheng ; Chen, Tien-Yu ; Lin, Pao-Yen ; Liang, Chih-Sung ; Hsu, Chih-Wei ; Tseng, Ping-Tao ; Li, Cheng-Ta</creator><creatorcontrib>Zeng, Bing-Yan ; Zeng, Bing-Syuan ; Chen, Yen-Wen ; Hung, Chao-Ming ; Sun, Cheuk-Kwan ; Cheng, Yu-Shian ; Stubbs, Brendon ; Carvalho, Andre F. ; Brunoni, Andre R. ; Su, Kuan-Pin ; Tu, Yu-Kang ; Wu, Yi-Cheng ; Chen, Tien-Yu ; Lin, Pao-Yen ; Liang, Chih-Sung ; Hsu, Chih-Wei ; Tseng, Ping-Tao ; Li, Cheng-Ta</creatorcontrib><description>Background/Objectives:
Obesity has recently been recognized as a neurocognitive disorder involving circuits associated with the reward system and the dorsolateral prefrontal cortex (DLPFC). Noninvasive brain stimulation (NIBS) has been proposed as a strategy for the management of obesity. However, the results have been inconclusive. The aim of the current network meta-analysis (NMA) was to evaluate the efficacy and acceptability of different NIBS modalities for weight reduction in participants with obesity.
Methods:
Randomized controlled trials (RCTs) examining NIBS interventions in patients with obesity were analyzed using the frequentist model of NMA. The coprimary outcome was change in body mass index (BMI) and acceptability, which was calculated using the dropout rate.
Results:
Overall, the current NMA, consisting of eight RCTs, revealed that the high-frequency repetitive transcranial magnetic stimulation (TMS) over the left DLPFC was ranked to be associated with the second-largest decrease in BMI and the largest decrease in total energy intake and craving severity, whereas the high-frequency deep TMS over bilateral DLPFC and the insula was ranked to be associated with the largest decrease in BMI.
Conclusion:
This pilot study provided a “signal” for the design of more methodologically robust and larger RCTs based on the findings of the potentially beneficial effect on weight reduction in participants with obesity by different NIBS interventions.</description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/s41366-021-00833-2</identifier><identifier>PMID: 33972697</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/378/1488/393 ; 692/699/2743/393 ; 692/700/2817 ; Acceptability ; Adult ; Body mass index ; Body size ; Brain ; Brain stimulation ; Care and treatment ; Clinical trials ; Cognition ; Energy intake ; Epidemiology ; Female ; Health Promotion and Disease Prevention ; Humans ; Internal Medicine ; Magnetic fields ; Male ; Medicine ; Medicine & Public Health ; Meta-analysis ; Metabolic Diseases ; Methods ; Middle Aged ; Network Meta-Analysis ; Obesity ; Obesity - physiopathology ; Obesity - therapy ; Pilot Projects ; Prefrontal cortex ; Public Health ; Randomized Controlled Trials as Topic ; Reinforcement ; Systematic review ; Testing ; Transcranial Magnetic Stimulation ; Weight Loss - physiology ; Weight reduction</subject><ispartof>International Journal of Obesity, 2021-08, Vol.45 (8), p.1705-1716</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Limited 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer Nature Limited.</rights><rights>COPYRIGHT 2021 Nature Publishing Group</rights><rights>The Author(s), under exclusive licence to Springer Nature Limited 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c539t-20be4043db67c644b805a68d41450ff175076141624a512a2ccd886d9625301f3</citedby><cites>FETCH-LOGICAL-c539t-20be4043db67c644b805a68d41450ff175076141624a512a2ccd886d9625301f3</cites><orcidid>0000-0003-1138-5586 ; 0000-0001-5761-7800 ; 0000-0002-0670-1153 ; 0000-0002-2461-474X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41366-021-00833-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41366-021-00833-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33972697$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zeng, Bing-Yan</creatorcontrib><creatorcontrib>Zeng, Bing-Syuan</creatorcontrib><creatorcontrib>Chen, Yen-Wen</creatorcontrib><creatorcontrib>Hung, Chao-Ming</creatorcontrib><creatorcontrib>Sun, Cheuk-Kwan</creatorcontrib><creatorcontrib>Cheng, Yu-Shian</creatorcontrib><creatorcontrib>Stubbs, Brendon</creatorcontrib><creatorcontrib>Carvalho, Andre F.</creatorcontrib><creatorcontrib>Brunoni, Andre R.</creatorcontrib><creatorcontrib>Su, Kuan-Pin</creatorcontrib><creatorcontrib>Tu, Yu-Kang</creatorcontrib><creatorcontrib>Wu, Yi-Cheng</creatorcontrib><creatorcontrib>Chen, Tien-Yu</creatorcontrib><creatorcontrib>Lin, Pao-Yen</creatorcontrib><creatorcontrib>Liang, Chih-Sung</creatorcontrib><creatorcontrib>Hsu, Chih-Wei</creatorcontrib><creatorcontrib>Tseng, Ping-Tao</creatorcontrib><creatorcontrib>Li, Cheng-Ta</creatorcontrib><title>Efficacy and acceptability of noninvasive brain stimulation interventions for weight reduction in obesity: a pilot network meta-analysis</title><title>International Journal of Obesity</title><addtitle>Int J Obes</addtitle><addtitle>Int J Obes (Lond)</addtitle><description>Background/Objectives:
Obesity has recently been recognized as a neurocognitive disorder involving circuits associated with the reward system and the dorsolateral prefrontal cortex (DLPFC). Noninvasive brain stimulation (NIBS) has been proposed as a strategy for the management of obesity. However, the results have been inconclusive. The aim of the current network meta-analysis (NMA) was to evaluate the efficacy and acceptability of different NIBS modalities for weight reduction in participants with obesity.
Methods:
Randomized controlled trials (RCTs) examining NIBS interventions in patients with obesity were analyzed using the frequentist model of NMA. The coprimary outcome was change in body mass index (BMI) and acceptability, which was calculated using the dropout rate.
Results:
Overall, the current NMA, consisting of eight RCTs, revealed that the high-frequency repetitive transcranial magnetic stimulation (TMS) over the left DLPFC was ranked to be associated with the second-largest decrease in BMI and the largest decrease in total energy intake and craving severity, whereas the high-frequency deep TMS over bilateral DLPFC and the insula was ranked to be associated with the largest decrease in BMI.
Conclusion:
This pilot study provided a “signal” for the design of more methodologically robust and larger RCTs based on the findings of the potentially beneficial effect on weight reduction in participants with obesity by different NIBS interventions.</description><subject>631/378/1488/393</subject><subject>692/699/2743/393</subject><subject>692/700/2817</subject><subject>Acceptability</subject><subject>Adult</subject><subject>Body mass index</subject><subject>Body size</subject><subject>Brain</subject><subject>Brain stimulation</subject><subject>Care and treatment</subject><subject>Clinical trials</subject><subject>Cognition</subject><subject>Energy intake</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Health Promotion and Disease Prevention</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Magnetic fields</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Meta-analysis</subject><subject>Metabolic Diseases</subject><subject>Methods</subject><subject>Middle Aged</subject><subject>Network Meta-Analysis</subject><subject>Obesity</subject><subject>Obesity - physiopathology</subject><subject>Obesity - therapy</subject><subject>Pilot Projects</subject><subject>Prefrontal cortex</subject><subject>Public Health</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Reinforcement</subject><subject>Systematic review</subject><subject>Testing</subject><subject>Transcranial Magnetic Stimulation</subject><subject>Weight Loss - physiology</subject><subject>Weight reduction</subject><issn>0307-0565</issn><issn>1476-5497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kl1rFDEUhoModlv9A15IQCjeTM33zHhXSq1CwRu9DpnMyW7qTLImmS37D_zZzn5orYjk4pCc533JObwIvaLkghLevMuCcqUqwmhFSMN5xZ6gBRW1qqRo66doQTipKyKVPEGnOd8RQqQk7Dk64bytmWrrBfpx7Zy3xm6xCT021sK6mM4PvmxxdDjE4MPGZL8B3CXjA87Fj9Ngio8B-1AgbSDsLhm7mPA9-OWq4AT9ZI8Ijh3k2e49Nnjth1hwgHIf0zc8QjGVCWbYZp9foGfODBleHusZ-vrh-svVx-r2882nq8vbykreloqRDgQRvO9UbZUQXUOkUU0vqJDEOVpLUisqqGLCSMoMs7ZvGtW3iklOqONn6O3Bd53i9wly0aPPFobBBIhT1kyyeWFcCjKjb_5C7-KU5v_uKCmaVhHKH6ilGUD74GJJxu5M9aVSraJS7L0u_kHNp4fR2xjA-fn9keD8D8EKzFBWOQ7TftePQXYAbYo5J3B6nfxo0lZTonc50Yec6Dknep8TzWbR6-NoUzdC_1vyKxgzwA9AnlthCelh9v_Y_gQ0osco</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Zeng, Bing-Yan</creator><creator>Zeng, Bing-Syuan</creator><creator>Chen, Yen-Wen</creator><creator>Hung, Chao-Ming</creator><creator>Sun, Cheuk-Kwan</creator><creator>Cheng, Yu-Shian</creator><creator>Stubbs, Brendon</creator><creator>Carvalho, Andre F.</creator><creator>Brunoni, Andre R.</creator><creator>Su, Kuan-Pin</creator><creator>Tu, Yu-Kang</creator><creator>Wu, Yi-Cheng</creator><creator>Chen, Tien-Yu</creator><creator>Lin, Pao-Yen</creator><creator>Liang, Chih-Sung</creator><creator>Hsu, Chih-Wei</creator><creator>Tseng, Ping-Tao</creator><creator>Li, Cheng-Ta</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7TK</scope><scope>7TS</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1138-5586</orcidid><orcidid>https://orcid.org/0000-0001-5761-7800</orcidid><orcidid>https://orcid.org/0000-0002-0670-1153</orcidid><orcidid>https://orcid.org/0000-0002-2461-474X</orcidid></search><sort><creationdate>20210801</creationdate><title>Efficacy and acceptability of noninvasive brain stimulation interventions for weight reduction in obesity: a pilot network meta-analysis</title><author>Zeng, Bing-Yan ; Zeng, Bing-Syuan ; Chen, Yen-Wen ; Hung, Chao-Ming ; Sun, Cheuk-Kwan ; Cheng, Yu-Shian ; Stubbs, Brendon ; Carvalho, Andre F. ; Brunoni, Andre R. ; Su, Kuan-Pin ; Tu, Yu-Kang ; Wu, Yi-Cheng ; Chen, Tien-Yu ; Lin, Pao-Yen ; Liang, Chih-Sung ; Hsu, Chih-Wei ; Tseng, Ping-Tao ; Li, Cheng-Ta</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c539t-20be4043db67c644b805a68d41450ff175076141624a512a2ccd886d9625301f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>631/378/1488/393</topic><topic>692/699/2743/393</topic><topic>692/700/2817</topic><topic>Acceptability</topic><topic>Adult</topic><topic>Body mass index</topic><topic>Body size</topic><topic>Brain</topic><topic>Brain stimulation</topic><topic>Care and treatment</topic><topic>Clinical trials</topic><topic>Cognition</topic><topic>Energy intake</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Health Promotion and Disease Prevention</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Magnetic fields</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Meta-analysis</topic><topic>Metabolic Diseases</topic><topic>Methods</topic><topic>Middle Aged</topic><topic>Network Meta-Analysis</topic><topic>Obesity</topic><topic>Obesity - physiopathology</topic><topic>Obesity - therapy</topic><topic>Pilot Projects</topic><topic>Prefrontal cortex</topic><topic>Public Health</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Reinforcement</topic><topic>Systematic review</topic><topic>Testing</topic><topic>Transcranial Magnetic Stimulation</topic><topic>Weight Loss - physiology</topic><topic>Weight reduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zeng, Bing-Yan</creatorcontrib><creatorcontrib>Zeng, Bing-Syuan</creatorcontrib><creatorcontrib>Chen, Yen-Wen</creatorcontrib><creatorcontrib>Hung, Chao-Ming</creatorcontrib><creatorcontrib>Sun, Cheuk-Kwan</creatorcontrib><creatorcontrib>Cheng, Yu-Shian</creatorcontrib><creatorcontrib>Stubbs, Brendon</creatorcontrib><creatorcontrib>Carvalho, Andre F.</creatorcontrib><creatorcontrib>Brunoni, Andre R.</creatorcontrib><creatorcontrib>Su, Kuan-Pin</creatorcontrib><creatorcontrib>Tu, Yu-Kang</creatorcontrib><creatorcontrib>Wu, Yi-Cheng</creatorcontrib><creatorcontrib>Chen, Tien-Yu</creatorcontrib><creatorcontrib>Lin, Pao-Yen</creatorcontrib><creatorcontrib>Liang, Chih-Sung</creatorcontrib><creatorcontrib>Hsu, Chih-Wei</creatorcontrib><creatorcontrib>Tseng, Ping-Tao</creatorcontrib><creatorcontrib>Li, Cheng-Ta</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>International Journal of Obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zeng, Bing-Yan</au><au>Zeng, Bing-Syuan</au><au>Chen, Yen-Wen</au><au>Hung, Chao-Ming</au><au>Sun, Cheuk-Kwan</au><au>Cheng, Yu-Shian</au><au>Stubbs, Brendon</au><au>Carvalho, Andre F.</au><au>Brunoni, Andre R.</au><au>Su, Kuan-Pin</au><au>Tu, Yu-Kang</au><au>Wu, Yi-Cheng</au><au>Chen, Tien-Yu</au><au>Lin, Pao-Yen</au><au>Liang, Chih-Sung</au><au>Hsu, Chih-Wei</au><au>Tseng, Ping-Tao</au><au>Li, Cheng-Ta</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy and acceptability of noninvasive brain stimulation interventions for weight reduction in obesity: a pilot network meta-analysis</atitle><jtitle>International Journal of Obesity</jtitle><stitle>Int J Obes</stitle><addtitle>Int J Obes (Lond)</addtitle><date>2021-08-01</date><risdate>2021</risdate><volume>45</volume><issue>8</issue><spage>1705</spage><epage>1716</epage><pages>1705-1716</pages><issn>0307-0565</issn><eissn>1476-5497</eissn><abstract>Background/Objectives:
Obesity has recently been recognized as a neurocognitive disorder involving circuits associated with the reward system and the dorsolateral prefrontal cortex (DLPFC). Noninvasive brain stimulation (NIBS) has been proposed as a strategy for the management of obesity. However, the results have been inconclusive. The aim of the current network meta-analysis (NMA) was to evaluate the efficacy and acceptability of different NIBS modalities for weight reduction in participants with obesity.
Methods:
Randomized controlled trials (RCTs) examining NIBS interventions in patients with obesity were analyzed using the frequentist model of NMA. The coprimary outcome was change in body mass index (BMI) and acceptability, which was calculated using the dropout rate.
Results:
Overall, the current NMA, consisting of eight RCTs, revealed that the high-frequency repetitive transcranial magnetic stimulation (TMS) over the left DLPFC was ranked to be associated with the second-largest decrease in BMI and the largest decrease in total energy intake and craving severity, whereas the high-frequency deep TMS over bilateral DLPFC and the insula was ranked to be associated with the largest decrease in BMI.
Conclusion:
This pilot study provided a “signal” for the design of more methodologically robust and larger RCTs based on the findings of the potentially beneficial effect on weight reduction in participants with obesity by different NIBS interventions.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>33972697</pmid><doi>10.1038/s41366-021-00833-2</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-1138-5586</orcidid><orcidid>https://orcid.org/0000-0001-5761-7800</orcidid><orcidid>https://orcid.org/0000-0002-0670-1153</orcidid><orcidid>https://orcid.org/0000-0002-2461-474X</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0307-0565 |
| ispartof | International Journal of Obesity, 2021-08, Vol.45 (8), p.1705-1716 |
| issn | 0307-0565 1476-5497 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2525653540 |
| source | MEDLINE; Nature Journals Online; SpringerLink Journals - AutoHoldings |
| subjects | 631/378/1488/393 692/699/2743/393 692/700/2817 Acceptability Adult Body mass index Body size Brain Brain stimulation Care and treatment Clinical trials Cognition Energy intake Epidemiology Female Health Promotion and Disease Prevention Humans Internal Medicine Magnetic fields Male Medicine Medicine & Public Health Meta-analysis Metabolic Diseases Methods Middle Aged Network Meta-Analysis Obesity Obesity - physiopathology Obesity - therapy Pilot Projects Prefrontal cortex Public Health Randomized Controlled Trials as Topic Reinforcement Systematic review Testing Transcranial Magnetic Stimulation Weight Loss - physiology Weight reduction |
| title | Efficacy and acceptability of noninvasive brain stimulation interventions for weight reduction in obesity: a pilot network meta-analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T06%3A28%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Efficacy%20and%20acceptability%20of%20noninvasive%20brain%20stimulation%20interventions%20for%20weight%20reduction%20in%20obesity:%20a%20pilot%20network%20meta-analysis&rft.jtitle=International%20Journal%20of%20Obesity&rft.au=Zeng,%20Bing-Yan&rft.date=2021-08-01&rft.volume=45&rft.issue=8&rft.spage=1705&rft.epage=1716&rft.pages=1705-1716&rft.issn=0307-0565&rft.eissn=1476-5497&rft_id=info:doi/10.1038/s41366-021-00833-2&rft_dat=%3Cgale_proqu%3EA669615440%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2554896013&rft_id=info:pmid/33972697&rft_galeid=A669615440&rfr_iscdi=true |