Apelin improves cardiac function mainly through peripheral vasodilation in a mouse model of dilated cardiomyopathy

•mActin-Tg mice displays a severe dilated cardiomyopathy phenotype.•[Pyr1]apelin-13 improves markedly cardiac function in mActin-Tg mice.•[Pyr1]apelin-13 does not change cardiac intrinsic contractility.•[Pyr1]apelin-13 increases cardiac function through reduction of vascular resistance. There is gro...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2021-08, Vol.142, p.170568-170568, Article 170568
Hauptverfasser:	El Mathari, Brahim, Briand, Pascale, Corbier, Alain, Poirier, Bruno, Briand, Véronique, Raffenne-Devillers, Alice, Harnist, Marie-Pierre, Guillot, Etienne, Guilbert, Frederique, Janiak, Philip
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apelin Apelin - pharmacology Blood Pressure Cardiomyopathy, Dilated - drug therapy Cardiomyopathy, Dilated - pathology Dilated cardiomyopathy Disease Models, Animal Heart failure Heart Rate Humans Mice Mice, Transgenic Peripheral Vascular Diseases - pathology Peripheral Vascular Diseases - prevention & control Peripheral vascular resistance Stroke Volume Vascular Resistance Vasodilation Ventricular load-independent contractility
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