Circulating C1q/TNF-related protein-12 levels are associated with the severity of coronary artery disease
Coronary artery disease (CAD) is the world's largest cause of death. The association of CAD with inflammation is well established. Recently, it has been confirmed that the C1q/TNF-related protein 12 (CTRP12) has a great anti-inflammatory effect. However, few data are available regarding the ser...
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| Veröffentlicht in: | Cytokine (Philadelphia, Pa.) Pa.), 2021-08, Vol.144, p.155545-155545, Article 155545 |
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| creator | Nadimi Shahraki, Zahra Azimi, Hanie Ilchi, Nasrin Rohani Borj, Mina Pourghadamyari, Hossein Mosallanejad, Saeedeh Abbaszadeh-Goudarzi, Kazem Sahebkar, Amirhossein |
| description | Coronary artery disease (CAD) is the world's largest cause of death. The association of CAD with inflammation is well established. Recently, it has been confirmed that the C1q/TNF-related protein 12 (CTRP12) has a great anti-inflammatory effect. However, few data are available regarding the serum CTRP12 concentration levels in CAD patients.
The study was performed to evaluate the correlation between the serum levels of CTRP12 and the CAD severity regarding to the number of affected vessels.
About 200 suspected CAD patients and 50 healthy ones as a control, were evaluated based on case-control study. According to the results of angiography, patients were divided into CAD+ (n = 150) with any major coronary artery stenosis ≥50% and CAD− (n = 50) with |
| doi_str_mv | 10.1016/j.cyto.2021.155545 |
| format | Article |
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The study was performed to evaluate the correlation between the serum levels of CTRP12 and the CAD severity regarding to the number of affected vessels.
About 200 suspected CAD patients and 50 healthy ones as a control, were evaluated based on case-control study. According to the results of angiography, patients were divided into CAD+ (n = 150) with any major coronary artery stenosis ≥50% and CAD− (n = 50) with <50% stenosis of the arteries. The CAD+patients were categorized into one- (1VD), two- (2VD) and three-vessel disease (3VD) based on the number of stenotic vessels. In the current study, different parameters such as CTRP12, tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), total oxidant status (TOS), total antioxidant capacity (TAC), and malondialdehyde (MDA) levels were evaluated, and also lipid profiles, hs-CRP and demographic factors were investigated as well.
Data revealed that CTRP12 and TAC levels in CAD + group were significantly lower than control subjects (P < 0.05). CTRP12 levels were found to be significantly lower in the 3VD compared with 1VD and 2VD subgroups (p < 0.01 and p < 0.05, respectively).
Our results confirmed that serum CTRP12 level is inversely associated with CAD severity. Therefore, it may be used as a prediction marker for CAD.</description><identifier>ISSN: 1043-4666</identifier><identifier>EISSN: 1096-0023</identifier><identifier>DOI: 10.1016/j.cyto.2021.155545</identifier><identifier>PMID: 33965313</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adipokine ; Adipokines - metabolism ; Antioxidants - metabolism ; Biomarkers - metabolism ; Case-Control Studies ; Complement C1q - metabolism ; Coronary Angiography - methods ; Coronary artery disease (CAD) ; Coronary Artery Disease - metabolism ; Female ; Humans ; Inflammation ; Inflammation - metabolism ; Male ; Malondialdehyde - metabolism ; Middle Aged ; Oxidative stress ; Risk Factors ; Severity of Illness Index</subject><ispartof>Cytokine (Philadelphia, Pa.), 2021-08, Vol.144, p.155545-155545, Article 155545</ispartof><rights>2021 Elsevier Ltd</rights><rights>Copyright © 2021 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-a7e9cd12b1f20cdd911a749f74016ea84a73a0d531020f13cb1e800edde2ac7b3</citedby><cites>FETCH-LOGICAL-c356t-a7e9cd12b1f20cdd911a749f74016ea84a73a0d531020f13cb1e800edde2ac7b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cyto.2021.155545$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33965313$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nadimi Shahraki, Zahra</creatorcontrib><creatorcontrib>Azimi, Hanie</creatorcontrib><creatorcontrib>Ilchi, Nasrin</creatorcontrib><creatorcontrib>Rohani Borj, Mina</creatorcontrib><creatorcontrib>Pourghadamyari, Hossein</creatorcontrib><creatorcontrib>Mosallanejad, Saeedeh</creatorcontrib><creatorcontrib>Abbaszadeh-Goudarzi, Kazem</creatorcontrib><creatorcontrib>Sahebkar, Amirhossein</creatorcontrib><title>Circulating C1q/TNF-related protein-12 levels are associated with the severity of coronary artery disease</title><title>Cytokine (Philadelphia, Pa.)</title><addtitle>Cytokine</addtitle><description>Coronary artery disease (CAD) is the world's largest cause of death. The association of CAD with inflammation is well established. Recently, it has been confirmed that the C1q/TNF-related protein 12 (CTRP12) has a great anti-inflammatory effect. However, few data are available regarding the serum CTRP12 concentration levels in CAD patients.
The study was performed to evaluate the correlation between the serum levels of CTRP12 and the CAD severity regarding to the number of affected vessels.
About 200 suspected CAD patients and 50 healthy ones as a control, were evaluated based on case-control study. According to the results of angiography, patients were divided into CAD+ (n = 150) with any major coronary artery stenosis ≥50% and CAD− (n = 50) with <50% stenosis of the arteries. The CAD+patients were categorized into one- (1VD), two- (2VD) and three-vessel disease (3VD) based on the number of stenotic vessels. In the current study, different parameters such as CTRP12, tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), total oxidant status (TOS), total antioxidant capacity (TAC), and malondialdehyde (MDA) levels were evaluated, and also lipid profiles, hs-CRP and demographic factors were investigated as well.
Data revealed that CTRP12 and TAC levels in CAD + group were significantly lower than control subjects (P < 0.05). CTRP12 levels were found to be significantly lower in the 3VD compared with 1VD and 2VD subgroups (p < 0.01 and p < 0.05, respectively).
Our results confirmed that serum CTRP12 level is inversely associated with CAD severity. Therefore, it may be used as a prediction marker for CAD.</description><subject>Adipokine</subject><subject>Adipokines - metabolism</subject><subject>Antioxidants - metabolism</subject><subject>Biomarkers - metabolism</subject><subject>Case-Control Studies</subject><subject>Complement C1q - metabolism</subject><subject>Coronary Angiography - methods</subject><subject>Coronary artery disease (CAD)</subject><subject>Coronary Artery Disease - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation - metabolism</subject><subject>Male</subject><subject>Malondialdehyde - metabolism</subject><subject>Middle Aged</subject><subject>Oxidative stress</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><issn>1043-4666</issn><issn>1096-0023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1PAjEURRujEUT_gAvTpZuBfswHk7gxRNSE6AbXTad9IyXDFNoOhn9vR9Clq9e0593cHoRuKRlTQvPJeqwOwY4ZYXRMsyxLszM0pKTME0IYP-_PKU_SPM8H6Mr7NSGk5EVxiQacl3nGKR8iMzNOdY0Mpv3EM7qbLN_miYN4ARpvnQ1g2oQy3MAeGo-lAyy9t8r8AF8mrHBYAfbx2ZlwwLbGyjrbSneIcIA4tPEgPVyji1o2Hm5Oc4Q-5k_L2UuyeH9-nT0uEsWzPCSygFJpyipaM6K0LimVRVrWRRq_DHKayoJLomN7wkhNuaooTAkBrYFJVVR8hO6PubH9rgMfxMZ4BU0jW7CdFyxj6XSaZkUZUXZElbPeO6jF1plNrC4oEb1isRa9YtErFkfFcenulN9VG9B_K79OI_BwBKIw2BtwwisDrQJtHKggtDX_5X8DwfCN3A</recordid><startdate>202108</startdate><enddate>202108</enddate><creator>Nadimi Shahraki, Zahra</creator><creator>Azimi, Hanie</creator><creator>Ilchi, Nasrin</creator><creator>Rohani Borj, Mina</creator><creator>Pourghadamyari, Hossein</creator><creator>Mosallanejad, Saeedeh</creator><creator>Abbaszadeh-Goudarzi, Kazem</creator><creator>Sahebkar, Amirhossein</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202108</creationdate><title>Circulating C1q/TNF-related protein-12 levels are associated with the severity of coronary artery disease</title><author>Nadimi Shahraki, Zahra ; Azimi, Hanie ; Ilchi, Nasrin ; Rohani Borj, Mina ; Pourghadamyari, Hossein ; Mosallanejad, Saeedeh ; Abbaszadeh-Goudarzi, Kazem ; Sahebkar, Amirhossein</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-a7e9cd12b1f20cdd911a749f74016ea84a73a0d531020f13cb1e800edde2ac7b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adipokine</topic><topic>Adipokines - metabolism</topic><topic>Antioxidants - metabolism</topic><topic>Biomarkers - metabolism</topic><topic>Case-Control Studies</topic><topic>Complement C1q - metabolism</topic><topic>Coronary Angiography - methods</topic><topic>Coronary artery disease (CAD)</topic><topic>Coronary Artery Disease - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammation - metabolism</topic><topic>Male</topic><topic>Malondialdehyde - metabolism</topic><topic>Middle Aged</topic><topic>Oxidative stress</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nadimi Shahraki, Zahra</creatorcontrib><creatorcontrib>Azimi, Hanie</creatorcontrib><creatorcontrib>Ilchi, Nasrin</creatorcontrib><creatorcontrib>Rohani Borj, Mina</creatorcontrib><creatorcontrib>Pourghadamyari, Hossein</creatorcontrib><creatorcontrib>Mosallanejad, Saeedeh</creatorcontrib><creatorcontrib>Abbaszadeh-Goudarzi, Kazem</creatorcontrib><creatorcontrib>Sahebkar, Amirhossein</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cytokine (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nadimi Shahraki, Zahra</au><au>Azimi, Hanie</au><au>Ilchi, Nasrin</au><au>Rohani Borj, Mina</au><au>Pourghadamyari, Hossein</au><au>Mosallanejad, Saeedeh</au><au>Abbaszadeh-Goudarzi, Kazem</au><au>Sahebkar, Amirhossein</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating C1q/TNF-related protein-12 levels are associated with the severity of coronary artery disease</atitle><jtitle>Cytokine (Philadelphia, Pa.)</jtitle><addtitle>Cytokine</addtitle><date>2021-08</date><risdate>2021</risdate><volume>144</volume><spage>155545</spage><epage>155545</epage><pages>155545-155545</pages><artnum>155545</artnum><issn>1043-4666</issn><eissn>1096-0023</eissn><abstract>Coronary artery disease (CAD) is the world's largest cause of death. The association of CAD with inflammation is well established. Recently, it has been confirmed that the C1q/TNF-related protein 12 (CTRP12) has a great anti-inflammatory effect. However, few data are available regarding the serum CTRP12 concentration levels in CAD patients.
The study was performed to evaluate the correlation between the serum levels of CTRP12 and the CAD severity regarding to the number of affected vessels.
About 200 suspected CAD patients and 50 healthy ones as a control, were evaluated based on case-control study. According to the results of angiography, patients were divided into CAD+ (n = 150) with any major coronary artery stenosis ≥50% and CAD− (n = 50) with <50% stenosis of the arteries. The CAD+patients were categorized into one- (1VD), two- (2VD) and three-vessel disease (3VD) based on the number of stenotic vessels. In the current study, different parameters such as CTRP12, tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), total oxidant status (TOS), total antioxidant capacity (TAC), and malondialdehyde (MDA) levels were evaluated, and also lipid profiles, hs-CRP and demographic factors were investigated as well.
Data revealed that CTRP12 and TAC levels in CAD + group were significantly lower than control subjects (P < 0.05). CTRP12 levels were found to be significantly lower in the 3VD compared with 1VD and 2VD subgroups (p < 0.01 and p < 0.05, respectively).
Our results confirmed that serum CTRP12 level is inversely associated with CAD severity. Therefore, it may be used as a prediction marker for CAD.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>33965313</pmid><doi>10.1016/j.cyto.2021.155545</doi><tpages>1</tpages></addata></record> |
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| ispartof | Cytokine (Philadelphia, Pa.), 2021-08, Vol.144, p.155545-155545, Article 155545 |
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| subjects | Adipokine Adipokines - metabolism Antioxidants - metabolism Biomarkers - metabolism Case-Control Studies Complement C1q - metabolism Coronary Angiography - methods Coronary artery disease (CAD) Coronary Artery Disease - metabolism Female Humans Inflammation Inflammation - metabolism Male Malondialdehyde - metabolism Middle Aged Oxidative stress Risk Factors Severity of Illness Index |
| title | Circulating C1q/TNF-related protein-12 levels are associated with the severity of coronary artery disease |
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