Adrenalitis and anasarca in idiopathic multicentric Castleman's disease
A 46-year-old man presented to our hospital with abdominal pain and fever. In his medical history he reported three previous episodes of varicella zoster. On examination, he had a temperature of 38·3°C, small cervical lymph nodes, and some right upper quadrant tenderness.A CT of the patient's a...
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| Veröffentlicht in: | The Lancet (British edition) 2021-05, Vol.397 (10286), p.1749-1749 |
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| container_issue | 10286 |
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| creator | Chen, Luke Y C Skinnider, Brian F Wilson, Don Fajgenbaum, David C |
| description | A 46-year-old man presented to our hospital with abdominal pain and fever. In his medical history he reported three previous episodes of varicella zoster. On examination, he had a temperature of 38·3°C, small cervical lymph nodes, and some right upper quadrant tenderness.A CT of the patient's abdomen showed bilateral adrenalitis (figure). Laboratory investigations showed marked cholestatic hepatitis—including a raised alkaline phosphatase (1 995 U/mL; normal 30–135). |
| doi_str_mv | 10.1016/S0140-6736(21)00674-7 |
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In his medical history he reported three previous episodes of varicella zoster. On examination, he had a temperature of 38·3°C, small cervical lymph nodes, and some right upper quadrant tenderness.A CT of the patient's abdomen showed bilateral adrenalitis (figure). Laboratory investigations showed marked cholestatic hepatitis—including a raised alkaline phosphatase (1 995 U/mL; normal 30–135).</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(21)00674-7</identifier><identifier>PMID: 33965090</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject><![CDATA[Abdomen ; Abdominal Pain - diagnosis ; Abdominal Pain - etiology ; Adrenal Gland Diseases - pathology ; Antibodies, Monoclonal - administration & dosage ; Antibodies, Monoclonal - therapeutic use ; Antineoplastic Agents - administration & dosage ; Antineoplastic Agents - therapeutic use ; Antineoplastic Agents, Hormonal - administration & dosage ; Antineoplastic Agents, Hormonal - therapeutic use ; Ascites ; Azetidines - administration & dosage ; Azetidines - therapeutic use ; Biopsy ; Bone marrow ; Bone Marrow - metabolism ; Bone Marrow - pathology ; Bortezomib - administration & dosage ; Bortezomib - therapeutic use ; Case reports ; Castleman Disease - diagnosis ; Castleman Disease - drug therapy ; Castleman Disease - pathology ; Castleman's disease ; Creatinine ; Cyclosporine - administration & dosage ; Cyclosporine - therapeutic use ; Cytokines ; Dexamethasone - administration & dosage ; Dexamethasone - therapeutic use ; Drug Therapy, Combination ; Edema ; Edema - pathology ; Fever - diagnosis ; Fever - etiology ; Humans ; Immunosuppressive Agents - administration & dosage ; Immunosuppressive Agents - therapeutic use ; Janus Kinase Inhibitors - administration & dosage ; Janus Kinase Inhibitors - therapeutic use ; Lymph nodes ; Male ; Middle Aged ; Purines - administration & dosage ; Purines - therapeutic use ; Pyrazoles - administration & dosage ; Pyrazoles - therapeutic use ; Renal Insufficiency - etiology ; Reticulin ; Severe acute respiratory syndrome coronavirus 2 ; Sulfonamides - administration & dosage ; Sulfonamides - therapeutic use ; Thrombocytopenia ; Thrombocytopenia - etiology]]></subject><ispartof>The Lancet (British edition), 2021-05, Vol.397 (10286), p.1749-1749</ispartof><rights>2021 Elsevier Ltd</rights><rights>2021. Elsevier Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c492t-274480d3b1bbf8f5e1653dd942e2da4aa700bbfc972cbfd5c3bf8d7e3369ec5b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0140673621006747$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33965090$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Luke Y C</creatorcontrib><creatorcontrib>Skinnider, Brian F</creatorcontrib><creatorcontrib>Wilson, Don</creatorcontrib><creatorcontrib>Fajgenbaum, David C</creatorcontrib><title>Adrenalitis and anasarca in idiopathic multicentric Castleman's disease</title><title>The Lancet (British edition)</title><addtitle>Lancet</addtitle><description>A 46-year-old man presented to our hospital with abdominal pain and fever. In his medical history he reported three previous episodes of varicella zoster. On examination, he had a temperature of 38·3°C, small cervical lymph nodes, and some right upper quadrant tenderness.A CT of the patient's abdomen showed bilateral adrenalitis (figure). Laboratory investigations showed marked cholestatic hepatitis—including a raised alkaline phosphatase (1 995 U/mL; normal 30–135).</description><subject>Abdomen</subject><subject>Abdominal Pain - diagnosis</subject><subject>Abdominal Pain - etiology</subject><subject>Adrenal Gland Diseases - pathology</subject><subject>Antibodies, Monoclonal - administration & dosage</subject><subject>Antibodies, Monoclonal - therapeutic use</subject><subject>Antineoplastic Agents - administration & dosage</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Antineoplastic Agents, Hormonal - administration & dosage</subject><subject>Antineoplastic Agents, Hormonal - therapeutic use</subject><subject>Ascites</subject><subject>Azetidines - administration & dosage</subject><subject>Azetidines - therapeutic use</subject><subject>Biopsy</subject><subject>Bone marrow</subject><subject>Bone Marrow - metabolism</subject><subject>Bone Marrow - pathology</subject><subject>Bortezomib - administration & dosage</subject><subject>Bortezomib - therapeutic use</subject><subject>Case reports</subject><subject>Castleman Disease - diagnosis</subject><subject>Castleman Disease - drug therapy</subject><subject>Castleman Disease - pathology</subject><subject>Castleman's disease</subject><subject>Creatinine</subject><subject>Cyclosporine - administration & dosage</subject><subject>Cyclosporine - therapeutic use</subject><subject>Cytokines</subject><subject>Dexamethasone - administration & dosage</subject><subject>Dexamethasone - therapeutic use</subject><subject>Drug Therapy, Combination</subject><subject>Edema</subject><subject>Edema - pathology</subject><subject>Fever - diagnosis</subject><subject>Fever - etiology</subject><subject>Humans</subject><subject>Immunosuppressive Agents - administration & dosage</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Janus Kinase Inhibitors - administration & dosage</subject><subject>Janus Kinase Inhibitors - therapeutic use</subject><subject>Lymph nodes</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Purines - administration & dosage</subject><subject>Purines - therapeutic use</subject><subject>Pyrazoles - administration & dosage</subject><subject>Pyrazoles - therapeutic use</subject><subject>Renal Insufficiency - etiology</subject><subject>Reticulin</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Sulfonamides - administration & dosage</subject><subject>Sulfonamides - therapeutic use</subject><subject>Thrombocytopenia</subject><subject>Thrombocytopenia - etiology</subject><issn>0140-6736</issn><issn>1474-547X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkMtKxTAQhoMoerw8glJwoS6qk1vTrkQO3kBwoYK7kCZTjPRyTFrBtzeeoy7cuAiTMN_8Qz5C9imcUqDF2QNQAXmheHHM6AlAoUSu1siMinSRQj2vk9kvskW2Y3wFAFGA3CRbnFeFhApm5PrCBexN60cfM9O7dEw0wZrM95l3fliY8cXbrJva0Vvsx5AecxPHFjvTH8XM-Ygm4i7ZaEwbce-77pCnq8vH-U1-d399O7-4y62o2JgzJUQJjte0rpuykUgLyZ2rBEPmjDBGAaSOrRSzdeOk5QlzCjkvKrSy5jvkeJW7CMPbhHHUnY8W29b0OExRM8lEWXKoeEIP_6CvwxTSX5cUkxUvaZkouaJsGGIM2OhF8J0JH5qC_jKtl6b1l0bNqF6a1irNHXynT3WH7nfqR20CzlcAJh3vHoOO1mNv0fmAdtRu8P-s-ATN5Y2H</recordid><startdate>20210508</startdate><enddate>20210508</enddate><creator>Chen, Luke Y C</creator><creator>Skinnider, Brian F</creator><creator>Wilson, Don</creator><creator>Fajgenbaum, David C</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TT</scope><scope>0TZ</scope><scope>0U~</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88C</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8C2</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K6X</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>KB~</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20210508</creationdate><title>Adrenalitis and anasarca in idiopathic multicentric Castleman's disease</title><author>Chen, Luke Y C ; Skinnider, Brian F ; Wilson, Don ; Fajgenbaum, David C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c492t-274480d3b1bbf8f5e1653dd942e2da4aa700bbfc972cbfd5c3bf8d7e3369ec5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Abdomen</topic><topic>Abdominal Pain - diagnosis</topic><topic>Abdominal Pain - etiology</topic><topic>Adrenal Gland Diseases - pathology</topic><topic>Antibodies, Monoclonal - administration & dosage</topic><topic>Antibodies, Monoclonal - therapeutic use</topic><topic>Antineoplastic Agents - administration & dosage</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Antineoplastic Agents, Hormonal - administration & dosage</topic><topic>Antineoplastic Agents, Hormonal - therapeutic use</topic><topic>Ascites</topic><topic>Azetidines - administration & dosage</topic><topic>Azetidines - therapeutic use</topic><topic>Biopsy</topic><topic>Bone marrow</topic><topic>Bone Marrow - metabolism</topic><topic>Bone Marrow - pathology</topic><topic>Bortezomib - administration & dosage</topic><topic>Bortezomib - therapeutic use</topic><topic>Case reports</topic><topic>Castleman Disease - diagnosis</topic><topic>Castleman Disease - drug therapy</topic><topic>Castleman Disease - pathology</topic><topic>Castleman's disease</topic><topic>Creatinine</topic><topic>Cyclosporine - administration & dosage</topic><topic>Cyclosporine - therapeutic use</topic><topic>Cytokines</topic><topic>Dexamethasone - administration & dosage</topic><topic>Dexamethasone - therapeutic use</topic><topic>Drug Therapy, Combination</topic><topic>Edema</topic><topic>Edema - pathology</topic><topic>Fever - diagnosis</topic><topic>Fever - etiology</topic><topic>Humans</topic><topic>Immunosuppressive Agents - administration & dosage</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>Janus Kinase Inhibitors - administration & dosage</topic><topic>Janus Kinase Inhibitors - therapeutic use</topic><topic>Lymph nodes</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Purines - administration & dosage</topic><topic>Purines - therapeutic use</topic><topic>Pyrazoles - administration & dosage</topic><topic>Pyrazoles - therapeutic use</topic><topic>Renal Insufficiency - etiology</topic><topic>Reticulin</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Sulfonamides - 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Academic</collection><jtitle>The Lancet (British edition)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Luke Y C</au><au>Skinnider, Brian F</au><au>Wilson, Don</au><au>Fajgenbaum, David C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adrenalitis and anasarca in idiopathic multicentric Castleman's disease</atitle><jtitle>The Lancet (British edition)</jtitle><addtitle>Lancet</addtitle><date>2021-05-08</date><risdate>2021</risdate><volume>397</volume><issue>10286</issue><spage>1749</spage><epage>1749</epage><pages>1749-1749</pages><issn>0140-6736</issn><eissn>1474-547X</eissn><abstract>A 46-year-old man presented to our hospital with abdominal pain and fever. In his medical history he reported three previous episodes of varicella zoster. On examination, he had a temperature of 38·3°C, small cervical lymph nodes, and some right upper quadrant tenderness.A CT of the patient's abdomen showed bilateral adrenalitis (figure). Laboratory investigations showed marked cholestatic hepatitis—including a raised alkaline phosphatase (1 995 U/mL; normal 30–135).</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>33965090</pmid><doi>10.1016/S0140-6736(21)00674-7</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Abdomen Abdominal Pain - diagnosis Abdominal Pain - etiology Adrenal Gland Diseases - pathology Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - therapeutic use Antineoplastic Agents - administration & dosage Antineoplastic Agents - therapeutic use Antineoplastic Agents, Hormonal - administration & dosage Antineoplastic Agents, Hormonal - therapeutic use Ascites Azetidines - administration & dosage Azetidines - therapeutic use Biopsy Bone marrow Bone Marrow - metabolism Bone Marrow - pathology Bortezomib - administration & dosage Bortezomib - therapeutic use Case reports Castleman Disease - diagnosis Castleman Disease - drug therapy Castleman Disease - pathology Castleman's disease Creatinine Cyclosporine - administration & dosage Cyclosporine - therapeutic use Cytokines Dexamethasone - administration & dosage Dexamethasone - therapeutic use Drug Therapy, Combination Edema Edema - pathology Fever - diagnosis Fever - etiology Humans Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - therapeutic use Janus Kinase Inhibitors - administration & dosage Janus Kinase Inhibitors - therapeutic use Lymph nodes Male Middle Aged Purines - administration & dosage Purines - therapeutic use Pyrazoles - administration & dosage Pyrazoles - therapeutic use Renal Insufficiency - etiology Reticulin Severe acute respiratory syndrome coronavirus 2 Sulfonamides - administration & dosage Sulfonamides - therapeutic use Thrombocytopenia Thrombocytopenia - etiology |
| title | Adrenalitis and anasarca in idiopathic multicentric Castleman's disease |
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