Editorial commentary: A heartbreaking relationship: Clonal hematopoiesis and heart failure
The concise review by Kenneth Walsh and colleagues summarizes the clinical association of clonal hematopoiesis and chronic heart failure, and the mechanistic insights into this unexpected relation of mutated blood cells and heart failure progression, which shows great promise to lead into therapeuti...
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| Veröffentlicht in: | Trends in cardiovascular medicine 2022-05, Vol.32 (4), p.204-205 |
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| container_title | Trends in cardiovascular medicine |
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| creator | Rieger, Michael A. |
| description | The concise review by Kenneth Walsh and colleagues summarizes the clinical association of clonal hematopoiesis and chronic heart failure, and the mechanistic insights into this unexpected relation of mutated blood cells and heart failure progression, which shows great promise to lead into therapeutic applications in the future [1]. While the existence of dominant blood cell clones in healthy individuals was described more than 25 years ago [4], only in recent years has the presence of recurrent somatic mutations in the hematopoietic system leading to the expansion of the mutated blood cell clone been widely recognized [5]. Nicholas Chavkin et al. have excellently addressed these and other questions in the context of the current clinical and experimental view of the detrimental relationship of blood stem cell mutations and chronic heart failure progression [1]. |
| doi_str_mv | 10.1016/j.tcm.2021.04.009 |
| format | Article |
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| fulltext | fulltext |
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| ispartof | Trends in cardiovascular medicine, 2022-05, Vol.32 (4), p.204-205 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Aging Blood Blood cells Blood stem cells Chronic heart failure Clonal Hematopoiesis Cloning Congestive heart failure Disease DNA methylation Epigenetics Genes Heart failure Heart Failure - diagnosis Heart Failure - genetics Heart Failure - therapy Hematopoietic stem cells Humans Mutation Patients Somatic mutations Stem cells Therapeutic applications |
| title | Editorial commentary: A heartbreaking relationship: Clonal hematopoiesis and heart failure |
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