MRTF-A regulates Ca2+ release through CACNA1S
Gene therapy is considered a potential treatment for Duchenne muscular dystrophy (DMD). Researchers have been working on this for many years to find effective therapeutic targets. Here, we found that MRTF-A (myocardin-related transcription factor A) could activate the transcription of L-type Ca 2+ -...
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| Veröffentlicht in: | Journal of biosciences 2021-06, Vol.46 (2), Article 40 |
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| creator | Liang, Chen Xu, Yao Peng, Zhen Luo, Ying Zhang, Tongcun |
| description | Gene therapy is considered a potential treatment for Duchenne muscular dystrophy (DMD). Researchers have been working on this for many years to find effective therapeutic targets. Here, we found that MRTF-A (myocardin-related transcription factor A) could activate the transcription of L-type Ca
2+
-channel-related protein CACNA1S (calcium voltage-gated channel subunit alpha1 S) by binding to the CarG box in the promoter of CACNA1S. However, increased phosphorylation and decreased expression of MRTF-A were observed, along with the expression of CACNA1S reduced in mdx mice. Further, the decreased expression and increased phosphorylation of MRTF-A could inhibit the release of Ca
2+
via CACNA1S. Therefore, MRTF-A may be a potential molecular target for the diagnosis and treatment of DMD. |
| doi_str_mv | 10.1007/s12038-021-00160-8 |
| format | Article |
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2+
-channel-related protein CACNA1S (calcium voltage-gated channel subunit alpha1 S) by binding to the CarG box in the promoter of CACNA1S. However, increased phosphorylation and decreased expression of MRTF-A were observed, along with the expression of CACNA1S reduced in mdx mice. Further, the decreased expression and increased phosphorylation of MRTF-A could inhibit the release of Ca
2+
via CACNA1S. Therefore, MRTF-A may be a potential molecular target for the diagnosis and treatment of DMD.</description><identifier>ISSN: 0250-5991</identifier><identifier>EISSN: 0973-7138</identifier><identifier>DOI: 10.1007/s12038-021-00160-8</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Biomedical and Life Sciences ; Biomedicine ; Calcium ; Calcium channels (L-type) ; Calcium channels (voltage-gated) ; Calcium ions ; Cell Biology ; Duchenne's muscular dystrophy ; Dystrophy ; Gene therapy ; Life Sciences ; Microbiology ; Muscular dystrophy ; Phosphorylation ; Plant Sciences ; Therapeutic targets ; Transcription ; Zoology</subject><ispartof>Journal of biosciences, 2021-06, Vol.46 (2), Article 40</ispartof><rights>Indian Academy of Sciences 2021</rights><rights>Indian Academy of Sciences 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c233t-bab5694e40cf30f30062115032debec8793763a1916985086b699afc96a76ddd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12038-021-00160-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12038-021-00160-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27911,27912,41475,42544,51306</link.rule.ids></links><search><creatorcontrib>Liang, Chen</creatorcontrib><creatorcontrib>Xu, Yao</creatorcontrib><creatorcontrib>Peng, Zhen</creatorcontrib><creatorcontrib>Luo, Ying</creatorcontrib><creatorcontrib>Zhang, Tongcun</creatorcontrib><title>MRTF-A regulates Ca2+ release through CACNA1S</title><title>Journal of biosciences</title><addtitle>J Biosci</addtitle><description>Gene therapy is considered a potential treatment for Duchenne muscular dystrophy (DMD). Researchers have been working on this for many years to find effective therapeutic targets. Here, we found that MRTF-A (myocardin-related transcription factor A) could activate the transcription of L-type Ca
2+
-channel-related protein CACNA1S (calcium voltage-gated channel subunit alpha1 S) by binding to the CarG box in the promoter of CACNA1S. However, increased phosphorylation and decreased expression of MRTF-A were observed, along with the expression of CACNA1S reduced in mdx mice. Further, the decreased expression and increased phosphorylation of MRTF-A could inhibit the release of Ca
2+
via CACNA1S. Therefore, MRTF-A may be a potential molecular target for the diagnosis and treatment of DMD.</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Calcium</subject><subject>Calcium channels (L-type)</subject><subject>Calcium channels (voltage-gated)</subject><subject>Calcium ions</subject><subject>Cell Biology</subject><subject>Duchenne's muscular dystrophy</subject><subject>Dystrophy</subject><subject>Gene therapy</subject><subject>Life Sciences</subject><subject>Microbiology</subject><subject>Muscular dystrophy</subject><subject>Phosphorylation</subject><subject>Plant Sciences</subject><subject>Therapeutic targets</subject><subject>Transcription</subject><subject>Zoology</subject><issn>0250-5991</issn><issn>0973-7138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kE1LxDAQhoMouK7-AU8FL4JEJ0nzdSzFVWFV0PUc0jbt7tJt16Q9-O-NVhA8CAMzA887Hy9C5wSuCYC8CYQCUxgowQBEAFYHaAZaMiwJU4exphww15oco5MQthHSKYMZwo8vqwXOEu-asbWDC0lu6VVsW2eDS4a178dmneRZ_pSR11N0VNs2uLOfPEdvi9tVfo-Xz3cPebbEJWVswIUtuNCpS6GsGcQAQQnhwGjlClcqqZkUzBJNhFYclCiE1rYutbBSVFXF5uhymrv3_fvowmB2m1C6trWd68dgKKepkpTH5-bo4g-67UffxesiFTekkjMWKTpRpe9D8K42e7_ZWf9hCJgvB83koIkOmm8HjYoiNolChLvG-d_R_6g-AabVbqo</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Liang, Chen</creator><creator>Xu, Yao</creator><creator>Peng, Zhen</creator><creator>Luo, Ying</creator><creator>Zhang, Tongcun</creator><general>Springer India</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H99</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L.F</scope><scope>L.G</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20210601</creationdate><title>MRTF-A regulates Ca2+ release through CACNA1S</title><author>Liang, Chen ; 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Researchers have been working on this for many years to find effective therapeutic targets. Here, we found that MRTF-A (myocardin-related transcription factor A) could activate the transcription of L-type Ca
2+
-channel-related protein CACNA1S (calcium voltage-gated channel subunit alpha1 S) by binding to the CarG box in the promoter of CACNA1S. However, increased phosphorylation and decreased expression of MRTF-A were observed, along with the expression of CACNA1S reduced in mdx mice. Further, the decreased expression and increased phosphorylation of MRTF-A could inhibit the release of Ca
2+
via CACNA1S. Therefore, MRTF-A may be a potential molecular target for the diagnosis and treatment of DMD.</abstract><cop>New Delhi</cop><pub>Springer India</pub><doi>10.1007/s12038-021-00160-8</doi></addata></record> |
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| subjects | Biomedical and Life Sciences Biomedicine Calcium Calcium channels (L-type) Calcium channels (voltage-gated) Calcium ions Cell Biology Duchenne's muscular dystrophy Dystrophy Gene therapy Life Sciences Microbiology Muscular dystrophy Phosphorylation Plant Sciences Therapeutic targets Transcription Zoology |
| title | MRTF-A regulates Ca2+ release through CACNA1S |
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