Sesquiterpene coumarins from Ferula samarkandica Korovin and their bioactivity

Phytochemical study on the ethanolic extract of the dried roots of Ferula samarkandica Korovin led to the isolation of nine undiscribed sesquiterpene coumarins, samarcandicins A−I, along with thirteen known sesquiterpene coumarins. Their structures were characterized by detailed spectroscopic analysis including NMR and HR-ESI-MS. Mogoltacin and nevskin exhibited high inhibitory activity against MV-4-11 cell with IC50 values of 3.94 ± 0.06 μM and 3.87 ± 0.10 μM, respectively, and nevskin and feshurin showed high inhibitory activity against mino cell with IC50 values of 1.48 ± 0.06 μM and 7.88 ± 0.60 μM, respectively. [Display omitted] •Nine undiscribed sesquiterpene coumarins were identified from the roots of Ferula samarcandica Korovin.•Mogoltacin and nevskin exhibited high inhibitory activity against MV-4-11 cell.•Nevskin and feshurin showed high inhibitory activity against mino cell.