T2 Relaxometry Evidence of Microstructural Changes in Diffusely Abnormal White Matter in Relapsing–Remitting Multiple Sclerosis and Clinically Isolated Syndrome: Impact on Visuomotor Performance
Background Although diffusely abnormal white matter (DAWM) is commonly seen in multiple sclerosis (MS), it is rarely considered in clinical/imaging studies. Purpose To evaluate quantitative markers of microstructural changes in DAWM of patients with clinically isolated syndrome (CIS) and relapsing–r...
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| Veröffentlicht in: | Journal of magnetic resonance imaging 2021-10, Vol.54 (4), p.1077-1087 |
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| creator | Papadaki, Efrosini Mastorodemos, Vasileios Panou, Theodora Pouli, Styliani Spyridaki, Eirini Kavroulakis, Eleftherios Kalaitzakis, Georgios Maris, Thomas G. Simos, Panagiotis |
| description | Background
Although diffusely abnormal white matter (DAWM) is commonly seen in multiple sclerosis (MS), it is rarely considered in clinical/imaging studies.
Purpose
To evaluate quantitative markers of microstructural changes in DAWM of patients with clinically isolated syndrome (CIS) and relapsing–remitting MS (RR‐MS) in relation to MS lesions and degree of neurocognitive impairment, by using a multi‐echo spin echo (MESE) Proton Density PD‐to‐T2 sequence.
Study Type
Prospective, cross‐sectional.
Population
Thirty‐seven RR‐MS patients, 33 CIS patients, and 52 healthy controls.
Field Strength/Sequence
1.5 T/T1‐, T2‐weighted, fluid‐attenuated inversion recovery, and MESE sequences.
Assessment
Long T2, short T2, and myelin water fraction (MWF) values were estimated as indices of intra/extracellular water content and myelin content, respectively, in DAWM, posterior periventricular normal appearing white matter (NAWM), and focal MS lesions, classified according to their signal intensity on T1 sequences. Patients were, also, administered a battery of neuropsychological tests.
Statistical Tests
Comparisons of T2 and MWF values in DAWM, NAWM, and MS lesions were examined, using two‐way mixed analyses of variance. Associations of Grooved Pegboard performance with T2 and MWF values in DAWM and NAWM were assessed using Pearson correlation coefficients.
Results
T2 and MWF values of DAWM were intermediate between the respective values of NAWM and T1 hypointense focal lesions, while there was no difference between the respective values of DAWM and T1‐isointense lesions. T2 values in DAWM were strongly associated with visuomotor performance in CIS patients.
Data Conclusion
Intra/extracellular water and myelin water content of DAWM are similar to those of T1‐isointense lesions and predict visuomotor performance in CIS patients.
Level of Evidence
2
Technical Efficacy
Stage 2 |
| doi_str_mv | 10.1002/jmri.27661 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_2524363485</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2524363485</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3571-1eb5411274730bd4f2e2ebbfa85ea56c50c8e469990dc361aa5a847d6b0fa1583</originalsourceid><addsrcrecordid>eNqNkUFu1DAUhiMEoqWw4QDIEhsESrEd20m6q0KBQR2BpgWWkeO8tB459mA7wOy4A1fiJJwEhxm6YIFY-Un-3u9f_rLsIcHHBGP6fD16fUxLIcit7JBwSnPKK3E7zZgXOalweZDdC2GNMa5rxu9mB0VRC4yFOMx-XFK0AiO_uhGi36Kzz7oHqwC5AS218i5EP6k4eWlQcy3tFQSkLXqhh2EKYLbotLPOj-n247WOgJYyRvAzMqdugrZXP799X8GoY0wzWk4m6o0BdKEMpHQdkLQ9aoy2WkmTAhfBGRmhRxdb2_tU6wQtxo1UETmLPugwudFF59E78MP8cip7P7szSBPgwf48yt6_PLtsXufnb18tmtPzXBW8JDmBjjNCaMnKAnc9GyhQ6LpBVhwkF4pjVQETdV3jXhWCSMllxcpedHiQhFfFUfZkl7vx7tMEIbajDgqMkRbcFFrKKStEwSqe0Md_oWs3eZvaJaqktKgrxhL1dEfNHx08DO3G61H6bUtwO7ttZ7ftb7cJfrSPnLoR-hv0j8wEVDvgC3RuCErPIm-wZF-wssY1TxMmjY4yamcbN9mYVp_9_2qiyZ7WBrb_6Ny-Wa4Wu_a_AL361KA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2572239844</pqid></control><display><type>article</type><title>T2 Relaxometry Evidence of Microstructural Changes in Diffusely Abnormal White Matter in Relapsing–Remitting Multiple Sclerosis and Clinically Isolated Syndrome: Impact on Visuomotor Performance</title><source>Access via Wiley Online Library</source><source>Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><creator>Papadaki, Efrosini ; Mastorodemos, Vasileios ; Panou, Theodora ; Pouli, Styliani ; Spyridaki, Eirini ; Kavroulakis, Eleftherios ; Kalaitzakis, Georgios ; Maris, Thomas G. ; Simos, Panagiotis</creator><creatorcontrib>Papadaki, Efrosini ; Mastorodemos, Vasileios ; Panou, Theodora ; Pouli, Styliani ; Spyridaki, Eirini ; Kavroulakis, Eleftherios ; Kalaitzakis, Georgios ; Maris, Thomas G. ; Simos, Panagiotis</creatorcontrib><description>Background
Although diffusely abnormal white matter (DAWM) is commonly seen in multiple sclerosis (MS), it is rarely considered in clinical/imaging studies.
Purpose
To evaluate quantitative markers of microstructural changes in DAWM of patients with clinically isolated syndrome (CIS) and relapsing–remitting MS (RR‐MS) in relation to MS lesions and degree of neurocognitive impairment, by using a multi‐echo spin echo (MESE) Proton Density PD‐to‐T2 sequence.
Study Type
Prospective, cross‐sectional.
Population
Thirty‐seven RR‐MS patients, 33 CIS patients, and 52 healthy controls.
Field Strength/Sequence
1.5 T/T1‐, T2‐weighted, fluid‐attenuated inversion recovery, and MESE sequences.
Assessment
Long T2, short T2, and myelin water fraction (MWF) values were estimated as indices of intra/extracellular water content and myelin content, respectively, in DAWM, posterior periventricular normal appearing white matter (NAWM), and focal MS lesions, classified according to their signal intensity on T1 sequences. Patients were, also, administered a battery of neuropsychological tests.
Statistical Tests
Comparisons of T2 and MWF values in DAWM, NAWM, and MS lesions were examined, using two‐way mixed analyses of variance. Associations of Grooved Pegboard performance with T2 and MWF values in DAWM and NAWM were assessed using Pearson correlation coefficients.
Results
T2 and MWF values of DAWM were intermediate between the respective values of NAWM and T1 hypointense focal lesions, while there was no difference between the respective values of DAWM and T1‐isointense lesions. T2 values in DAWM were strongly associated with visuomotor performance in CIS patients.
Data Conclusion
Intra/extracellular water and myelin water content of DAWM are similar to those of T1‐isointense lesions and predict visuomotor performance in CIS patients.
Level of Evidence
2
Technical Efficacy
Stage 2</description><identifier>ISSN: 1053-1807</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.27661</identifier><identifier>PMID: 33960066</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>clinically isolated syndrome ; Cognition ; Correlation coefficient ; Correlation coefficients ; diffusely abnormal white matter ; Field strength ; Lesions ; Life Sciences & Biomedicine ; Magnetic resonance imaging ; Moisture content ; Multiple sclerosis ; Myelin ; Patients ; Proton density (concentration) ; Radiology, Nuclear Medicine & Medical Imaging ; Science & Technology ; Sensorimotor integration ; Statistical analysis ; Statistical tests ; Substantia alba ; T2 relaxometry ; Variance analysis ; visuomotor impairment ; Water content</subject><ispartof>Journal of magnetic resonance imaging, 2021-10, Vol.54 (4), p.1077-1087</ispartof><rights>2021 International Society for Magnetic Resonance in Medicine</rights><rights>2021 International Society for Magnetic Resonance in Medicine.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>8</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000647909500001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c3571-1eb5411274730bd4f2e2ebbfa85ea56c50c8e469990dc361aa5a847d6b0fa1583</citedby><cites>FETCH-LOGICAL-c3571-1eb5411274730bd4f2e2ebbfa85ea56c50c8e469990dc361aa5a847d6b0fa1583</cites><orcidid>0000-0003-4409-6983 ; 0000-0002-3428-8298</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmri.27661$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmri.27661$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,27931,27932,39265,45581,45582</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33960066$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Papadaki, Efrosini</creatorcontrib><creatorcontrib>Mastorodemos, Vasileios</creatorcontrib><creatorcontrib>Panou, Theodora</creatorcontrib><creatorcontrib>Pouli, Styliani</creatorcontrib><creatorcontrib>Spyridaki, Eirini</creatorcontrib><creatorcontrib>Kavroulakis, Eleftherios</creatorcontrib><creatorcontrib>Kalaitzakis, Georgios</creatorcontrib><creatorcontrib>Maris, Thomas G.</creatorcontrib><creatorcontrib>Simos, Panagiotis</creatorcontrib><title>T2 Relaxometry Evidence of Microstructural Changes in Diffusely Abnormal White Matter in Relapsing–Remitting Multiple Sclerosis and Clinically Isolated Syndrome: Impact on Visuomotor Performance</title><title>Journal of magnetic resonance imaging</title><addtitle>J MAGN RESON IMAGING</addtitle><addtitle>J Magn Reson Imaging</addtitle><description>Background
Although diffusely abnormal white matter (DAWM) is commonly seen in multiple sclerosis (MS), it is rarely considered in clinical/imaging studies.
Purpose
To evaluate quantitative markers of microstructural changes in DAWM of patients with clinically isolated syndrome (CIS) and relapsing–remitting MS (RR‐MS) in relation to MS lesions and degree of neurocognitive impairment, by using a multi‐echo spin echo (MESE) Proton Density PD‐to‐T2 sequence.
Study Type
Prospective, cross‐sectional.
Population
Thirty‐seven RR‐MS patients, 33 CIS patients, and 52 healthy controls.
Field Strength/Sequence
1.5 T/T1‐, T2‐weighted, fluid‐attenuated inversion recovery, and MESE sequences.
Assessment
Long T2, short T2, and myelin water fraction (MWF) values were estimated as indices of intra/extracellular water content and myelin content, respectively, in DAWM, posterior periventricular normal appearing white matter (NAWM), and focal MS lesions, classified according to their signal intensity on T1 sequences. Patients were, also, administered a battery of neuropsychological tests.
Statistical Tests
Comparisons of T2 and MWF values in DAWM, NAWM, and MS lesions were examined, using two‐way mixed analyses of variance. Associations of Grooved Pegboard performance with T2 and MWF values in DAWM and NAWM were assessed using Pearson correlation coefficients.
Results
T2 and MWF values of DAWM were intermediate between the respective values of NAWM and T1 hypointense focal lesions, while there was no difference between the respective values of DAWM and T1‐isointense lesions. T2 values in DAWM were strongly associated with visuomotor performance in CIS patients.
Data Conclusion
Intra/extracellular water and myelin water content of DAWM are similar to those of T1‐isointense lesions and predict visuomotor performance in CIS patients.
Level of Evidence
2
Technical Efficacy
Stage 2</description><subject>clinically isolated syndrome</subject><subject>Cognition</subject><subject>Correlation coefficient</subject><subject>Correlation coefficients</subject><subject>diffusely abnormal white matter</subject><subject>Field strength</subject><subject>Lesions</subject><subject>Life Sciences & Biomedicine</subject><subject>Magnetic resonance imaging</subject><subject>Moisture content</subject><subject>Multiple sclerosis</subject><subject>Myelin</subject><subject>Patients</subject><subject>Proton density (concentration)</subject><subject>Radiology, Nuclear Medicine & Medical Imaging</subject><subject>Science & Technology</subject><subject>Sensorimotor integration</subject><subject>Statistical analysis</subject><subject>Statistical tests</subject><subject>Substantia alba</subject><subject>T2 relaxometry</subject><subject>Variance analysis</subject><subject>visuomotor impairment</subject><subject>Water content</subject><issn>1053-1807</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><recordid>eNqNkUFu1DAUhiMEoqWw4QDIEhsESrEd20m6q0KBQR2BpgWWkeO8tB459mA7wOy4A1fiJJwEhxm6YIFY-Un-3u9f_rLsIcHHBGP6fD16fUxLIcit7JBwSnPKK3E7zZgXOalweZDdC2GNMa5rxu9mB0VRC4yFOMx-XFK0AiO_uhGi36Kzz7oHqwC5AS218i5EP6k4eWlQcy3tFQSkLXqhh2EKYLbotLPOj-n247WOgJYyRvAzMqdugrZXP799X8GoY0wzWk4m6o0BdKEMpHQdkLQ9aoy2WkmTAhfBGRmhRxdb2_tU6wQtxo1UETmLPugwudFF59E78MP8cip7P7szSBPgwf48yt6_PLtsXufnb18tmtPzXBW8JDmBjjNCaMnKAnc9GyhQ6LpBVhwkF4pjVQETdV3jXhWCSMllxcpedHiQhFfFUfZkl7vx7tMEIbajDgqMkRbcFFrKKStEwSqe0Md_oWs3eZvaJaqktKgrxhL1dEfNHx08DO3G61H6bUtwO7ttZ7ftb7cJfrSPnLoR-hv0j8wEVDvgC3RuCErPIm-wZF-wssY1TxMmjY4yamcbN9mYVp_9_2qiyZ7WBrb_6Ny-Wa4Wu_a_AL361KA</recordid><startdate>202110</startdate><enddate>202110</enddate><creator>Papadaki, Efrosini</creator><creator>Mastorodemos, Vasileios</creator><creator>Panou, Theodora</creator><creator>Pouli, Styliani</creator><creator>Spyridaki, Eirini</creator><creator>Kavroulakis, Eleftherios</creator><creator>Kalaitzakis, Georgios</creator><creator>Maris, Thomas G.</creator><creator>Simos, Panagiotis</creator><general>John Wiley & Sons, Inc</general><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4409-6983</orcidid><orcidid>https://orcid.org/0000-0002-3428-8298</orcidid></search><sort><creationdate>202110</creationdate><title>T2 Relaxometry Evidence of Microstructural Changes in Diffusely Abnormal White Matter in Relapsing–Remitting Multiple Sclerosis and Clinically Isolated Syndrome: Impact on Visuomotor Performance</title><author>Papadaki, Efrosini ; Mastorodemos, Vasileios ; Panou, Theodora ; Pouli, Styliani ; Spyridaki, Eirini ; Kavroulakis, Eleftherios ; Kalaitzakis, Georgios ; Maris, Thomas G. ; Simos, Panagiotis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3571-1eb5411274730bd4f2e2ebbfa85ea56c50c8e469990dc361aa5a847d6b0fa1583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>clinically isolated syndrome</topic><topic>Cognition</topic><topic>Correlation coefficient</topic><topic>Correlation coefficients</topic><topic>diffusely abnormal white matter</topic><topic>Field strength</topic><topic>Lesions</topic><topic>Life Sciences & Biomedicine</topic><topic>Magnetic resonance imaging</topic><topic>Moisture content</topic><topic>Multiple sclerosis</topic><topic>Myelin</topic><topic>Patients</topic><topic>Proton density (concentration)</topic><topic>Radiology, Nuclear Medicine & Medical Imaging</topic><topic>Science & Technology</topic><topic>Sensorimotor integration</topic><topic>Statistical analysis</topic><topic>Statistical tests</topic><topic>Substantia alba</topic><topic>T2 relaxometry</topic><topic>Variance analysis</topic><topic>visuomotor impairment</topic><topic>Water content</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Papadaki, Efrosini</creatorcontrib><creatorcontrib>Mastorodemos, Vasileios</creatorcontrib><creatorcontrib>Panou, Theodora</creatorcontrib><creatorcontrib>Pouli, Styliani</creatorcontrib><creatorcontrib>Spyridaki, Eirini</creatorcontrib><creatorcontrib>Kavroulakis, Eleftherios</creatorcontrib><creatorcontrib>Kalaitzakis, Georgios</creatorcontrib><creatorcontrib>Maris, Thomas G.</creatorcontrib><creatorcontrib>Simos, Panagiotis</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Papadaki, Efrosini</au><au>Mastorodemos, Vasileios</au><au>Panou, Theodora</au><au>Pouli, Styliani</au><au>Spyridaki, Eirini</au><au>Kavroulakis, Eleftherios</au><au>Kalaitzakis, Georgios</au><au>Maris, Thomas G.</au><au>Simos, Panagiotis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>T2 Relaxometry Evidence of Microstructural Changes in Diffusely Abnormal White Matter in Relapsing–Remitting Multiple Sclerosis and Clinically Isolated Syndrome: Impact on Visuomotor Performance</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><stitle>J MAGN RESON IMAGING</stitle><addtitle>J Magn Reson Imaging</addtitle><date>2021-10</date><risdate>2021</risdate><volume>54</volume><issue>4</issue><spage>1077</spage><epage>1087</epage><pages>1077-1087</pages><issn>1053-1807</issn><eissn>1522-2586</eissn><abstract>Background
Although diffusely abnormal white matter (DAWM) is commonly seen in multiple sclerosis (MS), it is rarely considered in clinical/imaging studies.
Purpose
To evaluate quantitative markers of microstructural changes in DAWM of patients with clinically isolated syndrome (CIS) and relapsing–remitting MS (RR‐MS) in relation to MS lesions and degree of neurocognitive impairment, by using a multi‐echo spin echo (MESE) Proton Density PD‐to‐T2 sequence.
Study Type
Prospective, cross‐sectional.
Population
Thirty‐seven RR‐MS patients, 33 CIS patients, and 52 healthy controls.
Field Strength/Sequence
1.5 T/T1‐, T2‐weighted, fluid‐attenuated inversion recovery, and MESE sequences.
Assessment
Long T2, short T2, and myelin water fraction (MWF) values were estimated as indices of intra/extracellular water content and myelin content, respectively, in DAWM, posterior periventricular normal appearing white matter (NAWM), and focal MS lesions, classified according to their signal intensity on T1 sequences. Patients were, also, administered a battery of neuropsychological tests.
Statistical Tests
Comparisons of T2 and MWF values in DAWM, NAWM, and MS lesions were examined, using two‐way mixed analyses of variance. Associations of Grooved Pegboard performance with T2 and MWF values in DAWM and NAWM were assessed using Pearson correlation coefficients.
Results
T2 and MWF values of DAWM were intermediate between the respective values of NAWM and T1 hypointense focal lesions, while there was no difference between the respective values of DAWM and T1‐isointense lesions. T2 values in DAWM were strongly associated with visuomotor performance in CIS patients.
Data Conclusion
Intra/extracellular water and myelin water content of DAWM are similar to those of T1‐isointense lesions and predict visuomotor performance in CIS patients.
Level of Evidence
2
Technical Efficacy
Stage 2</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>33960066</pmid><doi>10.1002/jmri.27661</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-4409-6983</orcidid><orcidid>https://orcid.org/0000-0002-3428-8298</orcidid></addata></record> |
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| subjects | clinically isolated syndrome Cognition Correlation coefficient Correlation coefficients diffusely abnormal white matter Field strength Lesions Life Sciences & Biomedicine Magnetic resonance imaging Moisture content Multiple sclerosis Myelin Patients Proton density (concentration) Radiology, Nuclear Medicine & Medical Imaging Science & Technology Sensorimotor integration Statistical analysis Statistical tests Substantia alba T2 relaxometry Variance analysis visuomotor impairment Water content |
| title | T2 Relaxometry Evidence of Microstructural Changes in Diffusely Abnormal White Matter in Relapsing–Remitting Multiple Sclerosis and Clinically Isolated Syndrome: Impact on Visuomotor Performance |
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