Benzyl and phenethyl isothiocyanates as promising epigenetic drug compounds by modulating histone acetylation and methylation marks in malignant melanoma
Summary Melanoma is an aggressive skin cancer with increasing incidence rates globally. On the other hand, isothiocyanates are derived from cruciferous vegetables and are known to exert a wide range of anti-cancer activities including, among others, their ability to interact with the epigenome in or...
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| Veröffentlicht in: | Investigational new drugs 2021-12, Vol.39 (6), p.1460-1468 |
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| creator | Mitsiogianni, Melina Anestopoulos, Ioannis Kyriakou, Sotiris Trafalis, Dimitrios T. Franco, Rodrigo Pappa, Aglaia Panayiotidis, Mihalis I. |
| description | Summary
Melanoma is an aggressive skin cancer with increasing incidence rates globally. On the other hand, isothiocyanates are derived from cruciferous vegetables and are known to exert a wide range of anti-cancer activities including, among others, their ability to interact with the epigenome in order to supress cancer progression. The aim of this study was to determine the role of phenethyl and benzyl isothiocyanates in modulating histone acetylation and methylation as a potential epigenetic therapeutic strategy in an
in vitro
model of malignant melanoma. We report that both isothiocyanates induced cytotoxicity and influenced acetylation and methylation status of specific lysine residues on histones H3 and H4 by modulating the expression of various histone acetyltransferases, deacetylases and methyltransferases in malignant melanoma cells. Our data highlight novel insights on the interaction of isothiocyanates with components of the histone regulatory machinery in order to exert their anti-cancer action in malignant melanoma. |
| doi_str_mv | 10.1007/s10637-021-01127-0 |
| format | Article |
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Melanoma is an aggressive skin cancer with increasing incidence rates globally. On the other hand, isothiocyanates are derived from cruciferous vegetables and are known to exert a wide range of anti-cancer activities including, among others, their ability to interact with the epigenome in order to supress cancer progression. The aim of this study was to determine the role of phenethyl and benzyl isothiocyanates in modulating histone acetylation and methylation as a potential epigenetic therapeutic strategy in an
in vitro
model of malignant melanoma. We report that both isothiocyanates induced cytotoxicity and influenced acetylation and methylation status of specific lysine residues on histones H3 and H4 by modulating the expression of various histone acetyltransferases, deacetylases and methyltransferases in malignant melanoma cells. Our data highlight novel insights on the interaction of isothiocyanates with components of the histone regulatory machinery in order to exert their anti-cancer action in malignant melanoma.</description><identifier>ISSN: 0167-6997</identifier><identifier>EISSN: 1573-0646</identifier><identifier>DOI: 10.1007/s10637-021-01127-0</identifier><identifier>PMID: 33963962</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Acetylation ; Acetylation - drug effects ; Anticancer properties ; Cell Line, Tumor ; Cell Survival ; Cytotoxicity ; Epigenesis, Genetic ; Epigenetics ; Histones ; Histones - drug effects ; Humans ; Isothiocyanates - pharmacology ; Lysine ; Medicine ; Medicine & Public Health ; Melanoma ; Melanoma - physiopathology ; Methylation ; Methylation - drug effects ; Oncology ; Pharmacology/Toxicology ; Preclinical Studies ; Skin cancer ; Skin Neoplasms - physiopathology ; Toxicity</subject><ispartof>Investigational new drugs, 2021-12, Vol.39 (6), p.1460-1468</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-87f0dddf49c1ec8d597445eb9f752099655be0e721404fb81aacb30989e808283</citedby><cites>FETCH-LOGICAL-c375t-87f0dddf49c1ec8d597445eb9f752099655be0e721404fb81aacb30989e808283</cites><orcidid>0000-0002-1450-3552</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10637-021-01127-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10637-021-01127-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33963962$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mitsiogianni, Melina</creatorcontrib><creatorcontrib>Anestopoulos, Ioannis</creatorcontrib><creatorcontrib>Kyriakou, Sotiris</creatorcontrib><creatorcontrib>Trafalis, Dimitrios T.</creatorcontrib><creatorcontrib>Franco, Rodrigo</creatorcontrib><creatorcontrib>Pappa, Aglaia</creatorcontrib><creatorcontrib>Panayiotidis, Mihalis I.</creatorcontrib><title>Benzyl and phenethyl isothiocyanates as promising epigenetic drug compounds by modulating histone acetylation and methylation marks in malignant melanoma</title><title>Investigational new drugs</title><addtitle>Invest New Drugs</addtitle><addtitle>Invest New Drugs</addtitle><description>Summary
Melanoma is an aggressive skin cancer with increasing incidence rates globally. On the other hand, isothiocyanates are derived from cruciferous vegetables and are known to exert a wide range of anti-cancer activities including, among others, their ability to interact with the epigenome in order to supress cancer progression. The aim of this study was to determine the role of phenethyl and benzyl isothiocyanates in modulating histone acetylation and methylation as a potential epigenetic therapeutic strategy in an
in vitro
model of malignant melanoma. We report that both isothiocyanates induced cytotoxicity and influenced acetylation and methylation status of specific lysine residues on histones H3 and H4 by modulating the expression of various histone acetyltransferases, deacetylases and methyltransferases in malignant melanoma cells. Our data highlight novel insights on the interaction of isothiocyanates with components of the histone regulatory machinery in order to exert their anti-cancer action in malignant melanoma.</description><subject>Acetylation</subject><subject>Acetylation - drug effects</subject><subject>Anticancer properties</subject><subject>Cell Line, Tumor</subject><subject>Cell Survival</subject><subject>Cytotoxicity</subject><subject>Epigenesis, Genetic</subject><subject>Epigenetics</subject><subject>Histones</subject><subject>Histones - drug effects</subject><subject>Humans</subject><subject>Isothiocyanates - pharmacology</subject><subject>Lysine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Melanoma</subject><subject>Melanoma - physiopathology</subject><subject>Methylation</subject><subject>Methylation - drug effects</subject><subject>Oncology</subject><subject>Pharmacology/Toxicology</subject><subject>Preclinical Studies</subject><subject>Skin cancer</subject><subject>Skin Neoplasms - physiopathology</subject><subject>Toxicity</subject><issn>0167-6997</issn><issn>1573-0646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp9kctu1TAQhi0EoocDL8ACWWLDJuBLHMdLqLhJlbpp15bjTHJcEjvEziJ9E962zkkBiQWSJc94vrn5R-g1Je8pIfJDpKTisiCMFoRSlq0n6ECF5AWpyuopOhBayaJSSl6gFzHeEUK4kuVzdMG5qvJhB_TrE_j7dcDGt3g6gYd0yp6LIZ1csKvxJkHEJuJpDqOLzvcYJtdvoLO4nZce2zBOYfFtxM2Kx9Aug0kbd3IxBQ_YWEjr9hb8uc147rH7o5l_ROw2Y3C9Nz7l8GB8GM1L9KwzQ4RXj_cR3X75fHP5rbi6_vr98uNVYbkUqahlR9q27UplKdi6FXnDUkCjOikYUaoSogECktGSlF1TU2Nsw4mqFdSkZjU_ond73bzhzwVi0nlPC0OeAsISNROs5KJSYkPf_oPehWX2ebpM1WUthchffERsp-wcYpyh09Ps8qKrpkRvwuldOJ2F02fh9Jb05rH00ozQ_kn5rVQG-A7EHPI9zH97_6fsAyDOpx4</recordid><startdate>20211201</startdate><enddate>20211201</enddate><creator>Mitsiogianni, Melina</creator><creator>Anestopoulos, Ioannis</creator><creator>Kyriakou, Sotiris</creator><creator>Trafalis, Dimitrios T.</creator><creator>Franco, Rodrigo</creator><creator>Pappa, Aglaia</creator><creator>Panayiotidis, Mihalis I.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X7</scope><scope>7XB</scope><scope>87Z</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FL</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FRNLG</scope><scope>FYUFA</scope><scope>F~G</scope><scope>GHDGH</scope><scope>K60</scope><scope>K6~</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>L.-</scope><scope>M0C</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1450-3552</orcidid></search><sort><creationdate>20211201</creationdate><title>Benzyl and phenethyl isothiocyanates as promising epigenetic drug compounds by modulating histone acetylation and methylation marks in malignant melanoma</title><author>Mitsiogianni, Melina ; Anestopoulos, Ioannis ; Kyriakou, Sotiris ; Trafalis, Dimitrios T. ; Franco, Rodrigo ; Pappa, Aglaia ; Panayiotidis, Mihalis I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-87f0dddf49c1ec8d597445eb9f752099655be0e721404fb81aacb30989e808283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acetylation</topic><topic>Acetylation - drug effects</topic><topic>Anticancer properties</topic><topic>Cell Line, Tumor</topic><topic>Cell Survival</topic><topic>Cytotoxicity</topic><topic>Epigenesis, Genetic</topic><topic>Epigenetics</topic><topic>Histones</topic><topic>Histones - drug effects</topic><topic>Humans</topic><topic>Isothiocyanates - pharmacology</topic><topic>Lysine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Melanoma</topic><topic>Melanoma - physiopathology</topic><topic>Methylation</topic><topic>Methylation - drug effects</topic><topic>Oncology</topic><topic>Pharmacology/Toxicology</topic><topic>Preclinical Studies</topic><topic>Skin cancer</topic><topic>Skin Neoplasms - physiopathology</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mitsiogianni, Melina</creatorcontrib><creatorcontrib>Anestopoulos, Ioannis</creatorcontrib><creatorcontrib>Kyriakou, Sotiris</creatorcontrib><creatorcontrib>Trafalis, Dimitrios T.</creatorcontrib><creatorcontrib>Franco, Rodrigo</creatorcontrib><creatorcontrib>Pappa, Aglaia</creatorcontrib><creatorcontrib>Panayiotidis, Mihalis I.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>ProQuest Nursing & Allied Health Database</collection><collection>ABI/INFORM Collection</collection><collection>ABI/INFORM Global (PDF only)</collection><collection>Health Medical collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ABI/INFORM Collection</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ABI/INFORM Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Business Premium Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Business Premium Collection (Alumni)</collection><collection>Health Research Premium Collection</collection><collection>ABI/INFORM Global (Corporate)</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Business Collection (Alumni Edition)</collection><collection>ProQuest Business Collection</collection><collection>Consumer Health Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ABI/INFORM Professional Advanced</collection><collection>ABI/INFORM Global</collection><collection>ProQuest Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>One Business (ProQuest)</collection><collection>ProQuest One Business (Alumni)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Investigational new drugs</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mitsiogianni, Melina</au><au>Anestopoulos, Ioannis</au><au>Kyriakou, Sotiris</au><au>Trafalis, Dimitrios T.</au><au>Franco, Rodrigo</au><au>Pappa, Aglaia</au><au>Panayiotidis, Mihalis I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Benzyl and phenethyl isothiocyanates as promising epigenetic drug compounds by modulating histone acetylation and methylation marks in malignant melanoma</atitle><jtitle>Investigational new drugs</jtitle><stitle>Invest New Drugs</stitle><addtitle>Invest New Drugs</addtitle><date>2021-12-01</date><risdate>2021</risdate><volume>39</volume><issue>6</issue><spage>1460</spage><epage>1468</epage><pages>1460-1468</pages><issn>0167-6997</issn><eissn>1573-0646</eissn><abstract>Summary
Melanoma is an aggressive skin cancer with increasing incidence rates globally. On the other hand, isothiocyanates are derived from cruciferous vegetables and are known to exert a wide range of anti-cancer activities including, among others, their ability to interact with the epigenome in order to supress cancer progression. The aim of this study was to determine the role of phenethyl and benzyl isothiocyanates in modulating histone acetylation and methylation as a potential epigenetic therapeutic strategy in an
in vitro
model of malignant melanoma. We report that both isothiocyanates induced cytotoxicity and influenced acetylation and methylation status of specific lysine residues on histones H3 and H4 by modulating the expression of various histone acetyltransferases, deacetylases and methyltransferases in malignant melanoma cells. Our data highlight novel insights on the interaction of isothiocyanates with components of the histone regulatory machinery in order to exert their anti-cancer action in malignant melanoma.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>33963962</pmid><doi>10.1007/s10637-021-01127-0</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-1450-3552</orcidid></addata></record> |
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| subjects | Acetylation Acetylation - drug effects Anticancer properties Cell Line, Tumor Cell Survival Cytotoxicity Epigenesis, Genetic Epigenetics Histones Histones - drug effects Humans Isothiocyanates - pharmacology Lysine Medicine Medicine & Public Health Melanoma Melanoma - physiopathology Methylation Methylation - drug effects Oncology Pharmacology/Toxicology Preclinical Studies Skin cancer Skin Neoplasms - physiopathology Toxicity |
| title | Benzyl and phenethyl isothiocyanates as promising epigenetic drug compounds by modulating histone acetylation and methylation marks in malignant melanoma |
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