Energy and corticosteroid mobilization following an induced stress response in an elasmobranch fish, the North Pacific spiny dogfish (Squalus acanthias suckleyi)
•1α-OHB is not correlated with glucose in a representative elasmobranch.•1α-OHB is weakly correlated with β-HB in a representative elasmobranch.•Other hormonal factors may play a role in regulating energy metabolism.•Circulating levels of 1αOH-B were elevated post-induced stressors. The dominant cor...
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| creator | Schoen, Alexandra N. Treberg, Jason R. Wheaton, Catharine J. Mylniczenko, Natalie Gary Anderson, W. |
| description | •1α-OHB is not correlated with glucose in a representative elasmobranch.•1α-OHB is weakly correlated with β-HB in a representative elasmobranch.•Other hormonal factors may play a role in regulating energy metabolism.•Circulating levels of 1αOH-B were elevated post-induced stressors.
The dominant corticosteroid in elasmobranchs, 1α-hydroxycorticosterone (1α-OHB), has a described role in mineral regulation but a presumptive role in energy balance. Energy demand in vertebrates following exposure to a stressor typically involves an immediate but transient release of glucocorticoids as a means of mobilizing available energy stores, usually in the form of glucose. Although a glucocorticoid role for 1α-OHB would be expected, direct glucocorticoid function of this steroid has yet to be reported in any elasmobranch. In addition, elasmobranchs also utilize the metabolite β-hydroxybutyrate (β-HB), which is thought to replace the role fatty acids play in most vertebrates as a predominant fuel source in extrahepatic tissues. To determine the mobilization of metabolites and corticosteroids during a stress event, North Pacific spiny dogfish, Squalus acanthias suckleyi, were cannulated and held in a darkened isolation box to recover (24–48 h) before being subjected to an acute air exposure or corticosterone injection. Dogfish were then serially blood sampled at nine timepoints over 48 h. Glucose, β-HB, 1α-OHB, corticosterone, as well as lactate, pH, and osmolality were quantified in plasma samples. All measured variables increased in control and treatment groups within 48 h from the start of experimentation, and β-HB and 1α-OHB remained elevated for the duration of the experiment. There was no linear correlation between glucose and 1α-OHB, but there was a weak (R2 = 0.230) although significant (p = 0.001), positive correlation between β-HB and 1α-OHB. Interestingly, there were also significant correlations between increasing circulating glucose and corticosterone (R2 = 0.349; p |
| doi_str_mv | 10.1016/j.ygcen.2021.113799 |
| format | Article |
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The dominant corticosteroid in elasmobranchs, 1α-hydroxycorticosterone (1α-OHB), has a described role in mineral regulation but a presumptive role in energy balance. Energy demand in vertebrates following exposure to a stressor typically involves an immediate but transient release of glucocorticoids as a means of mobilizing available energy stores, usually in the form of glucose. Although a glucocorticoid role for 1α-OHB would be expected, direct glucocorticoid function of this steroid has yet to be reported in any elasmobranch. In addition, elasmobranchs also utilize the metabolite β-hydroxybutyrate (β-HB), which is thought to replace the role fatty acids play in most vertebrates as a predominant fuel source in extrahepatic tissues. To determine the mobilization of metabolites and corticosteroids during a stress event, North Pacific spiny dogfish, Squalus acanthias suckleyi, were cannulated and held in a darkened isolation box to recover (24–48 h) before being subjected to an acute air exposure or corticosterone injection. Dogfish were then serially blood sampled at nine timepoints over 48 h. Glucose, β-HB, 1α-OHB, corticosterone, as well as lactate, pH, and osmolality were quantified in plasma samples. All measured variables increased in control and treatment groups within 48 h from the start of experimentation, and β-HB and 1α-OHB remained elevated for the duration of the experiment. There was no linear correlation between glucose and 1α-OHB, but there was a weak (R2 = 0.230) although significant (p = 0.001), positive correlation between β-HB and 1α-OHB. Interestingly, there were also significant correlations between increasing circulating glucose and corticosterone (R2 = 0.349; p < 0.001), and decreasing β-HB and corticosterone concentrations (R2 = 0.180; p = 0.008). Our data suggest that following successive stressors of capture, surgery, and confinement, 1α-OHB was not correlated with circulating glucose, only weakly correlated with circulating β-HB concentrations (R2 = 0.230; p = 0.001), and that corticosterone may also serve a role in energy mobilization in this species.</description><identifier>ISSN: 0016-6480</identifier><identifier>EISSN: 1095-6840</identifier><identifier>DOI: 10.1016/j.ygcen.2021.113799</identifier><identifier>PMID: 33961877</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>1α-hydroxycorticosterone ; Animals ; Corticosteroid ; Corticosterone - metabolism ; Dogfish ; Elasmobranch ; Elasmobranchii ; Glucose ; Metabolism ; Squalus - metabolism ; Squalus acanthias ; Stress ; β-hydroxybutyrate</subject><ispartof>General and comparative endocrinology, 2021-09, Vol.310, p.113799-113799, Article 113799</ispartof><rights>2021 Elsevier Inc.</rights><rights>Copyright © 2021 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-f8133fd7441778aba05bfa38d499c0efbe8fc3c80eb12fefa99b78d51a4cb7783</citedby><cites>FETCH-LOGICAL-c359t-f8133fd7441778aba05bfa38d499c0efbe8fc3c80eb12fefa99b78d51a4cb7783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ygcen.2021.113799$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33961877$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schoen, Alexandra N.</creatorcontrib><creatorcontrib>Treberg, Jason R.</creatorcontrib><creatorcontrib>Wheaton, Catharine J.</creatorcontrib><creatorcontrib>Mylniczenko, Natalie</creatorcontrib><creatorcontrib>Gary Anderson, W.</creatorcontrib><title>Energy and corticosteroid mobilization following an induced stress response in an elasmobranch fish, the North Pacific spiny dogfish (Squalus acanthias suckleyi)</title><title>General and comparative endocrinology</title><addtitle>Gen Comp Endocrinol</addtitle><description>•1α-OHB is not correlated with glucose in a representative elasmobranch.•1α-OHB is weakly correlated with β-HB in a representative elasmobranch.•Other hormonal factors may play a role in regulating energy metabolism.•Circulating levels of 1αOH-B were elevated post-induced stressors.
The dominant corticosteroid in elasmobranchs, 1α-hydroxycorticosterone (1α-OHB), has a described role in mineral regulation but a presumptive role in energy balance. Energy demand in vertebrates following exposure to a stressor typically involves an immediate but transient release of glucocorticoids as a means of mobilizing available energy stores, usually in the form of glucose. Although a glucocorticoid role for 1α-OHB would be expected, direct glucocorticoid function of this steroid has yet to be reported in any elasmobranch. In addition, elasmobranchs also utilize the metabolite β-hydroxybutyrate (β-HB), which is thought to replace the role fatty acids play in most vertebrates as a predominant fuel source in extrahepatic tissues. To determine the mobilization of metabolites and corticosteroids during a stress event, North Pacific spiny dogfish, Squalus acanthias suckleyi, were cannulated and held in a darkened isolation box to recover (24–48 h) before being subjected to an acute air exposure or corticosterone injection. Dogfish were then serially blood sampled at nine timepoints over 48 h. Glucose, β-HB, 1α-OHB, corticosterone, as well as lactate, pH, and osmolality were quantified in plasma samples. All measured variables increased in control and treatment groups within 48 h from the start of experimentation, and β-HB and 1α-OHB remained elevated for the duration of the experiment. There was no linear correlation between glucose and 1α-OHB, but there was a weak (R2 = 0.230) although significant (p = 0.001), positive correlation between β-HB and 1α-OHB. Interestingly, there were also significant correlations between increasing circulating glucose and corticosterone (R2 = 0.349; p < 0.001), and decreasing β-HB and corticosterone concentrations (R2 = 0.180; p = 0.008). Our data suggest that following successive stressors of capture, surgery, and confinement, 1α-OHB was not correlated with circulating glucose, only weakly correlated with circulating β-HB concentrations (R2 = 0.230; p = 0.001), and that corticosterone may also serve a role in energy mobilization in this species.</description><subject>1α-hydroxycorticosterone</subject><subject>Animals</subject><subject>Corticosteroid</subject><subject>Corticosterone - metabolism</subject><subject>Dogfish</subject><subject>Elasmobranch</subject><subject>Elasmobranchii</subject><subject>Glucose</subject><subject>Metabolism</subject><subject>Squalus - metabolism</subject><subject>Squalus acanthias</subject><subject>Stress</subject><subject>β-hydroxybutyrate</subject><issn>0016-6480</issn><issn>1095-6840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9u1DAQhy0EokvhCZCQj0VqFjvOPx84oKqFSlVBAs6WY483XrL21pOAwtv0TfGyLUcuHsn-fjPyfIS85mzNGW_ebdfLxkBYl6zka85FK-UTsuJM1kXTVewpWbGMFU3VsRPyAnHLGKtFw5-TEyFkw7u2XZH7ywBps1AdLDUxTd5EnCBFb-ku9n70v_XkY6AujmP85cMmk9QHOxuwFKcEiDQf-xgQ8v3hFUaNOZt0MAN1HodzOg1Ab3P3gX7RxjtvKO59WKiNmwNAz77ezXqckWqjwzR4jRRn82OExb99SZ45PSK8eqin5PvV5beLT8XN54_XFx9uCiNqORWu40I421YVb9tO95rVvdOis5WUhoHroXNGmI5Bz0sHTkvZt52tua5MnxPilJwd--5TvJsBJ7XzaGAcdYA4oyrrshJ1U0qWUXFETYqICZzaJ7_TaVGcqYMbtVV_3aiDG3V0k1NvHgbM_Q7sv8yjjAy8PwKQv_nTQ1JoPIS8aZ_ATMpG_98BfwDSGKWp</recordid><startdate>20210901</startdate><enddate>20210901</enddate><creator>Schoen, Alexandra N.</creator><creator>Treberg, Jason R.</creator><creator>Wheaton, Catharine J.</creator><creator>Mylniczenko, Natalie</creator><creator>Gary Anderson, W.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20210901</creationdate><title>Energy and corticosteroid mobilization following an induced stress response in an elasmobranch fish, the North Pacific spiny dogfish (Squalus acanthias suckleyi)</title><author>Schoen, Alexandra N. ; Treberg, Jason R. ; Wheaton, Catharine J. ; Mylniczenko, Natalie ; Gary Anderson, W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-f8133fd7441778aba05bfa38d499c0efbe8fc3c80eb12fefa99b78d51a4cb7783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>1α-hydroxycorticosterone</topic><topic>Animals</topic><topic>Corticosteroid</topic><topic>Corticosterone - metabolism</topic><topic>Dogfish</topic><topic>Elasmobranch</topic><topic>Elasmobranchii</topic><topic>Glucose</topic><topic>Metabolism</topic><topic>Squalus - metabolism</topic><topic>Squalus acanthias</topic><topic>Stress</topic><topic>β-hydroxybutyrate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schoen, Alexandra N.</creatorcontrib><creatorcontrib>Treberg, Jason R.</creatorcontrib><creatorcontrib>Wheaton, Catharine J.</creatorcontrib><creatorcontrib>Mylniczenko, Natalie</creatorcontrib><creatorcontrib>Gary Anderson, W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>General and comparative endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schoen, Alexandra N.</au><au>Treberg, Jason R.</au><au>Wheaton, Catharine J.</au><au>Mylniczenko, Natalie</au><au>Gary Anderson, W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Energy and corticosteroid mobilization following an induced stress response in an elasmobranch fish, the North Pacific spiny dogfish (Squalus acanthias suckleyi)</atitle><jtitle>General and comparative endocrinology</jtitle><addtitle>Gen Comp Endocrinol</addtitle><date>2021-09-01</date><risdate>2021</risdate><volume>310</volume><spage>113799</spage><epage>113799</epage><pages>113799-113799</pages><artnum>113799</artnum><issn>0016-6480</issn><eissn>1095-6840</eissn><abstract>•1α-OHB is not correlated with glucose in a representative elasmobranch.•1α-OHB is weakly correlated with β-HB in a representative elasmobranch.•Other hormonal factors may play a role in regulating energy metabolism.•Circulating levels of 1αOH-B were elevated post-induced stressors.
The dominant corticosteroid in elasmobranchs, 1α-hydroxycorticosterone (1α-OHB), has a described role in mineral regulation but a presumptive role in energy balance. Energy demand in vertebrates following exposure to a stressor typically involves an immediate but transient release of glucocorticoids as a means of mobilizing available energy stores, usually in the form of glucose. Although a glucocorticoid role for 1α-OHB would be expected, direct glucocorticoid function of this steroid has yet to be reported in any elasmobranch. In addition, elasmobranchs also utilize the metabolite β-hydroxybutyrate (β-HB), which is thought to replace the role fatty acids play in most vertebrates as a predominant fuel source in extrahepatic tissues. To determine the mobilization of metabolites and corticosteroids during a stress event, North Pacific spiny dogfish, Squalus acanthias suckleyi, were cannulated and held in a darkened isolation box to recover (24–48 h) before being subjected to an acute air exposure or corticosterone injection. Dogfish were then serially blood sampled at nine timepoints over 48 h. Glucose, β-HB, 1α-OHB, corticosterone, as well as lactate, pH, and osmolality were quantified in plasma samples. All measured variables increased in control and treatment groups within 48 h from the start of experimentation, and β-HB and 1α-OHB remained elevated for the duration of the experiment. There was no linear correlation between glucose and 1α-OHB, but there was a weak (R2 = 0.230) although significant (p = 0.001), positive correlation between β-HB and 1α-OHB. Interestingly, there were also significant correlations between increasing circulating glucose and corticosterone (R2 = 0.349; p < 0.001), and decreasing β-HB and corticosterone concentrations (R2 = 0.180; p = 0.008). Our data suggest that following successive stressors of capture, surgery, and confinement, 1α-OHB was not correlated with circulating glucose, only weakly correlated with circulating β-HB concentrations (R2 = 0.230; p = 0.001), and that corticosterone may also serve a role in energy mobilization in this species.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>33961877</pmid><doi>10.1016/j.ygcen.2021.113799</doi><tpages>1</tpages></addata></record> |
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| subjects | 1α-hydroxycorticosterone Animals Corticosteroid Corticosterone - metabolism Dogfish Elasmobranch Elasmobranchii Glucose Metabolism Squalus - metabolism Squalus acanthias Stress β-hydroxybutyrate |
| title | Energy and corticosteroid mobilization following an induced stress response in an elasmobranch fish, the North Pacific spiny dogfish (Squalus acanthias suckleyi) |
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