Transcription factor 4 controls positioning of cortical projection neurons through regulation of cell adhesion

The establishment of neural circuits depends on precise neuronal positioning in the cortex, which occurs via a tightly coordinated process of neuronal differentiation, migration, and terminal localization. Deficits in this process have been implicated in several psychiatric disorders. Here, we show...

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Veröffentlicht in:	Molecular psychiatry 2021-11, Vol.26 (11), p.6562-6577
Hauptverfasser:	Zhang, Yandong, Cai, Zheping, Hu, Guanglei, Hu, Songhui, Wang, Yafei, Li, Na, Chen, Saiyong, Liu, Qiong, Zeng, Lanhui, Tang, Tianxiang, Zhang, Yilan, Xiao, Lei, Gu, Yu, Xie, Yunli
Format:	Artikel
Sprache:	eng
Schlagworte:	13/51 14/19 38/109 38/39 631/337 631/378 64/60 692/699/476/1373 9/74 Behavioral Sciences Biological Psychology Brain research Causes of Cell Adhesion Cell adhesion & migration Cell adhesion molecules Cellular control mechanisms Central nervous system diseases Cerebral cortex Child development deviations Developmental disabilities Electrophysiology Facies Health aspects Humans Hyperventilation - genetics Hyperventilation - metabolism Intellectual disabilities Intellectual Disability - genetics Localization Medicine Medicine & Public Health Mental disorders Mutation Neural circuitry Neural networks Neurons Neurons - metabolism Neurosciences Pharmacotherapy Physiological aspects Psychiatry Schizophrenia Transcription Factor 4 - genetics Transcription Factor 4 - metabolism Transcription factors
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