Longitudinal changes in adherence to the portfolio and DASH dietary patterns and cardiometabolic risk factors in the PREDIMED-Plus study
The Portfolio and Dietary Approaches to Stop Hypertension (DASH) diets have been shown to lower cardiometabolic risk factors in randomized controlled trials (RCTs). However, the Portfolio diet has only been assessed in RCTs of hyperlipidemic patients. Therefore, to assess the Portfolio diet in a pop...
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creator | Glenn, Andrea J. Hernández-Alonso, Pablo Kendall, Cyril W.C. Martínez-González, Miguel Ángel Corella, Dolores Fitó, Montserrat Martínez, J.Alfredo Alonso-Gómez, Ángel M. Wärnberg, Julia Vioque, Jesús Romaguera, Dora López-Miranda, José Estruch, Ramon Tinahones, Francisco J. Lapetra, José Serra-Majem, J. Luís Bueno-Cavanillas, Aurora Tur, Josep A. Celada, Sofia Reguero Pintó, Xavier Delgado-Rodríguez, Miguel Matía-Martín, Pilar Vidal, Josep Mas-Fontao, Sebastian Daimiel, Lidia Ros, Emilio Jenkins, David J.A. Toledo, Estefania Sorlí, José V. Castañer, Olga Abete, Itziar Rodriguez, Anai Moreno Barceló, Olga Fernández Oncina-Canovas, Alejandro Konieczna, Jadwiga Garcia-Rios, Antonio Casas, Rosa Gómez-Pérez, Ana Maria Santos-Lozano, José Manuel Vazquez-Ruiz, Zenaida Portolés, Olga Schröder, Helmut Zulet, Maria A. Eguaras, Sonia Lete, Itziar Salaverria Zomeño, María Dolores Sievenpiper, John L. Salas-Salvadó, Jordi |
description | The Portfolio and Dietary Approaches to Stop Hypertension (DASH) diets have been shown to lower cardiometabolic risk factors in randomized controlled trials (RCTs). However, the Portfolio diet has only been assessed in RCTs of hyperlipidemic patients. Therefore, to assess the Portfolio diet in a population with metabolic syndrome (MetS), we conducted a longitudinal analysis of one-year data of changes in the Portfolio and DASH diet scores and their association with cardiometabolic risk factors in Prevención con Dieta Mediterránea (PREDIMED)-Plus trial.
PREDIMED-Plus is an ongoing clinical trial (Trial registration: ISRCTN89898) conducted in Spain that includes 6874 older participants (mean age 65 y, 48% women) with overweight/obesity fulfilling at least three criteria for MetS. Data for this analysis were collected at baseline, six months and one year. Adherence to the Portfolio and DASH diet scores were derived from a validated 143-item food frequency questionnaire. We used linear mixed models to examine the associations of 1-SD increase and quartile changes in the diet scores with concomitant changes in cardiometabolic risk factors.
After adjusting for several potential confounders, a 1-SD increase in the Portfolio diet score was significantly associated with lower HbA1c (β [95% CI]: −0.02% [−0.02, −0.01], P |
doi_str_mv | 10.1016/j.clnu.2021.03.016 |
format | Article |
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PREDIMED-Plus is an ongoing clinical trial (Trial registration: ISRCTN89898) conducted in Spain that includes 6874 older participants (mean age 65 y, 48% women) with overweight/obesity fulfilling at least three criteria for MetS. Data for this analysis were collected at baseline, six months and one year. Adherence to the Portfolio and DASH diet scores were derived from a validated 143-item food frequency questionnaire. We used linear mixed models to examine the associations of 1-SD increase and quartile changes in the diet scores with concomitant changes in cardiometabolic risk factors.
After adjusting for several potential confounders, a 1-SD increase in the Portfolio diet score was significantly associated with lower HbA1c (β [95% CI]: −0.02% [−0.02, −0.01], P < 0.001), fasting glucose (−0.47 mg/dL [−0.83, −0.11], P = 0.01), triglycerides (−1.29 mg/dL [−2.31, −0.28], P = 0.01), waist circumference (WC) (−0.51 cm [−0.59, −0.43], P < 0.001), and body mass index (BMI) (−0.17 kg/m2 [−0.19, −0.15], P < 0.001). A 1-SD increase in the DASH diet score was significantly associated with lower HbA1c (−0.03% [−0.04, −0.02], P < 0.001), glucose (−0.84 mg/dL [−1.18, −0.51], P < 0.001), triglycerides (−3.38 mg/dL [−4.37, −2.38], P < 0.001), non-HDL-cholesterol (−0.47 mg/dL [−0.91, −0.04], P = 0.03), WC (−0.69 cm [−0.76, −0.60 cm], P < 0.001), BMI (−0.25 kg/m2 [−0.28, −0.26 kg/m2], P < 0.001), systolic blood pressure (−0.57 mmHg [−0.81, −0.32 mmHg], P < 0.001), diastolic blood pressure (−0.15 mmHg [−0.29, −0.01 mmHg], P = 0.03), and with higher HDL-cholesterol (0.21 mg/dL [0.09, 0.34 mg/dL, P = 0.001]). Similar associations were seen when both diet scores were assessed as quartiles, comparing extreme categories of adherence.
Among older adults at high cardiovascular risk with MetS, greater adherence to the Portfolio and DASH diets showed significant favourable prospective associations with several clinically relevant cardiometabolic risk factors. Both diets are likely beneficial for cardiometabolic risk reduction.]]></description><identifier>ISSN: 0261-5614</identifier><identifier>EISSN: 1532-1983</identifier><identifier>DOI: 10.1016/j.clnu.2021.03.016</identifier><identifier>PMID: 33933749</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>age ; body mass index ; Cardiometabolic risk ; clinical nutrition ; clinical trials ; DASH diet ; diastolic blood pressure ; Dietary Approaches to Stop Hypertension diet ; Dietary patterns ; food frequency questionnaires ; glucose ; high density lipoprotein cholesterol ; hypertension ; longitudinal studies ; Metabolic syndrome ; obesity ; population ; PORTFOLIO diet ; PREDIMED-Plus trial ; risk ; risk reduction ; Spain ; systolic blood pressure ; waist circumference</subject><ispartof>Clinical nutrition (Edinburgh, Scotland), 2021-05, Vol.40 (5), p.2825-2836</ispartof><rights>2021 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism</rights><rights>Copyright © 2021 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c433t-e744d8387433164d15c39f22d6e14d41ceb7ee7b08cb86d6f169b608fab55eb13</citedby><cites>FETCH-LOGICAL-c433t-e744d8387433164d15c39f22d6e14d41ceb7ee7b08cb86d6f169b608fab55eb13</cites><orcidid>0000-0002-0211-9166 ; 0000-0002-0649-3016 ; 0000-0002-6940-0761 ; 0000-0001-9898-6629 ; 0000-0002-3270-5772 ; 0000-0001-6604-3327 ; 0000-0001-6286-964X ; 0000-0002-6828-9627 ; 0000-0002-3926-0892 ; 0000-0002-2947-1338</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0261561421001552$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33933749$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Glenn, Andrea J.</creatorcontrib><creatorcontrib>Hernández-Alonso, Pablo</creatorcontrib><creatorcontrib>Kendall, Cyril W.C.</creatorcontrib><creatorcontrib>Martínez-González, Miguel Ángel</creatorcontrib><creatorcontrib>Corella, Dolores</creatorcontrib><creatorcontrib>Fitó, Montserrat</creatorcontrib><creatorcontrib>Martínez, J.Alfredo</creatorcontrib><creatorcontrib>Alonso-Gómez, Ángel M.</creatorcontrib><creatorcontrib>Wärnberg, Julia</creatorcontrib><creatorcontrib>Vioque, Jesús</creatorcontrib><creatorcontrib>Romaguera, Dora</creatorcontrib><creatorcontrib>López-Miranda, José</creatorcontrib><creatorcontrib>Estruch, Ramon</creatorcontrib><creatorcontrib>Tinahones, Francisco J.</creatorcontrib><creatorcontrib>Lapetra, José</creatorcontrib><creatorcontrib>Serra-Majem, J. Luís</creatorcontrib><creatorcontrib>Bueno-Cavanillas, Aurora</creatorcontrib><creatorcontrib>Tur, Josep A.</creatorcontrib><creatorcontrib>Celada, Sofia Reguero</creatorcontrib><creatorcontrib>Pintó, Xavier</creatorcontrib><creatorcontrib>Delgado-Rodríguez, Miguel</creatorcontrib><creatorcontrib>Matía-Martín, Pilar</creatorcontrib><creatorcontrib>Vidal, Josep</creatorcontrib><creatorcontrib>Mas-Fontao, Sebastian</creatorcontrib><creatorcontrib>Daimiel, Lidia</creatorcontrib><creatorcontrib>Ros, Emilio</creatorcontrib><creatorcontrib>Jenkins, David J.A.</creatorcontrib><creatorcontrib>Toledo, Estefania</creatorcontrib><creatorcontrib>Sorlí, José V.</creatorcontrib><creatorcontrib>Castañer, Olga</creatorcontrib><creatorcontrib>Abete, Itziar</creatorcontrib><creatorcontrib>Rodriguez, Anai Moreno</creatorcontrib><creatorcontrib>Barceló, Olga Fernández</creatorcontrib><creatorcontrib>Oncina-Canovas, Alejandro</creatorcontrib><creatorcontrib>Konieczna, Jadwiga</creatorcontrib><creatorcontrib>Garcia-Rios, Antonio</creatorcontrib><creatorcontrib>Casas, Rosa</creatorcontrib><creatorcontrib>Gómez-Pérez, Ana Maria</creatorcontrib><creatorcontrib>Santos-Lozano, José Manuel</creatorcontrib><creatorcontrib>Vazquez-Ruiz, Zenaida</creatorcontrib><creatorcontrib>Portolés, Olga</creatorcontrib><creatorcontrib>Schröder, Helmut</creatorcontrib><creatorcontrib>Zulet, Maria A.</creatorcontrib><creatorcontrib>Eguaras, Sonia</creatorcontrib><creatorcontrib>Lete, Itziar Salaverria</creatorcontrib><creatorcontrib>Zomeño, María Dolores</creatorcontrib><creatorcontrib>Sievenpiper, John L.</creatorcontrib><creatorcontrib>Salas-Salvadó, Jordi</creatorcontrib><title>Longitudinal changes in adherence to the portfolio and DASH dietary patterns and cardiometabolic risk factors in the PREDIMED-Plus study</title><title>Clinical nutrition (Edinburgh, Scotland)</title><addtitle>Clin Nutr</addtitle><description><![CDATA[The Portfolio and Dietary Approaches to Stop Hypertension (DASH) diets have been shown to lower cardiometabolic risk factors in randomized controlled trials (RCTs). However, the Portfolio diet has only been assessed in RCTs of hyperlipidemic patients. Therefore, to assess the Portfolio diet in a population with metabolic syndrome (MetS), we conducted a longitudinal analysis of one-year data of changes in the Portfolio and DASH diet scores and their association with cardiometabolic risk factors in Prevención con Dieta Mediterránea (PREDIMED)-Plus trial.
PREDIMED-Plus is an ongoing clinical trial (Trial registration: ISRCTN89898) conducted in Spain that includes 6874 older participants (mean age 65 y, 48% women) with overweight/obesity fulfilling at least three criteria for MetS. Data for this analysis were collected at baseline, six months and one year. Adherence to the Portfolio and DASH diet scores were derived from a validated 143-item food frequency questionnaire. We used linear mixed models to examine the associations of 1-SD increase and quartile changes in the diet scores with concomitant changes in cardiometabolic risk factors.
After adjusting for several potential confounders, a 1-SD increase in the Portfolio diet score was significantly associated with lower HbA1c (β [95% CI]: −0.02% [−0.02, −0.01], P < 0.001), fasting glucose (−0.47 mg/dL [−0.83, −0.11], P = 0.01), triglycerides (−1.29 mg/dL [−2.31, −0.28], P = 0.01), waist circumference (WC) (−0.51 cm [−0.59, −0.43], P < 0.001), and body mass index (BMI) (−0.17 kg/m2 [−0.19, −0.15], P < 0.001). A 1-SD increase in the DASH diet score was significantly associated with lower HbA1c (−0.03% [−0.04, −0.02], P < 0.001), glucose (−0.84 mg/dL [−1.18, −0.51], P < 0.001), triglycerides (−3.38 mg/dL [−4.37, −2.38], P < 0.001), non-HDL-cholesterol (−0.47 mg/dL [−0.91, −0.04], P = 0.03), WC (−0.69 cm [−0.76, −0.60 cm], P < 0.001), BMI (−0.25 kg/m2 [−0.28, −0.26 kg/m2], P < 0.001), systolic blood pressure (−0.57 mmHg [−0.81, −0.32 mmHg], P < 0.001), diastolic blood pressure (−0.15 mmHg [−0.29, −0.01 mmHg], P = 0.03), and with higher HDL-cholesterol (0.21 mg/dL [0.09, 0.34 mg/dL, P = 0.001]). Similar associations were seen when both diet scores were assessed as quartiles, comparing extreme categories of adherence.
Among older adults at high cardiovascular risk with MetS, greater adherence to the Portfolio and DASH diets showed significant favourable prospective associations with several clinically relevant cardiometabolic risk factors. Both diets are likely beneficial for cardiometabolic risk reduction.]]></description><subject>age</subject><subject>body mass index</subject><subject>Cardiometabolic risk</subject><subject>clinical nutrition</subject><subject>clinical trials</subject><subject>DASH diet</subject><subject>diastolic blood pressure</subject><subject>Dietary Approaches to Stop Hypertension diet</subject><subject>Dietary patterns</subject><subject>food frequency questionnaires</subject><subject>glucose</subject><subject>high density lipoprotein cholesterol</subject><subject>hypertension</subject><subject>longitudinal studies</subject><subject>Metabolic syndrome</subject><subject>obesity</subject><subject>population</subject><subject>PORTFOLIO diet</subject><subject>PREDIMED-Plus trial</subject><subject>risk</subject><subject>risk reduction</subject><subject>Spain</subject><subject>systolic blood pressure</subject><subject>waist circumference</subject><issn>0261-5614</issn><issn>1532-1983</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqNkc9u1DAQxi0EosvCC3BAPnJJ6n9xEolL1V1opa1aFThbjj3pesnGi-1U6hvw2DjdlmPFZayZ-eZn6fsQ-khJSQmVp7vSDONUMsJoSXiZR6_QglacFbRt-Gu0IEzSopJUnKB3Me4IIRWvm7fohPOW81q0C_Rn48c7lybrRj1gs9XjHUTsRqztFgKMBnDyOG0BH3xIvR-cx3q0eHX2_QJbB0mHB3zQKUEY4-PG6GCd3-dNl9UGBxd_4V6b5MMjeGbd3K5Xl1frVXEzTBHH_P3De_Sm10OED0_vEv38uv5xflFsrr9dnp9tCiM4TwXUQtiGN3XuqBSWVoa3PWNWAhVWUANdDVB3pDFdI63sqWw7SZped1UFHeVL9PnIPQT_e4KY1N5FA8OgR_BTVKxiGd3IXP9DSkXLaTZzidhRaoKPMUCvDsHtszeKEjWHpXZqDkvNYSnCVR7lo09P_Knbg_138pxOFnw5CiAbcu8gqGjcnIl1AUxS1ruX-H8BimKmXw</recordid><startdate>20210501</startdate><enddate>20210501</enddate><creator>Glenn, Andrea J.</creator><creator>Hernández-Alonso, Pablo</creator><creator>Kendall, Cyril W.C.</creator><creator>Martínez-González, Miguel Ángel</creator><creator>Corella, Dolores</creator><creator>Fitó, Montserrat</creator><creator>Martínez, J.Alfredo</creator><creator>Alonso-Gómez, Ángel M.</creator><creator>Wärnberg, Julia</creator><creator>Vioque, Jesús</creator><creator>Romaguera, Dora</creator><creator>López-Miranda, José</creator><creator>Estruch, Ramon</creator><creator>Tinahones, Francisco J.</creator><creator>Lapetra, José</creator><creator>Serra-Majem, J. 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Luís ; Bueno-Cavanillas, Aurora ; Tur, Josep A. ; Celada, Sofia Reguero ; Pintó, Xavier ; Delgado-Rodríguez, Miguel ; Matía-Martín, Pilar ; Vidal, Josep ; Mas-Fontao, Sebastian ; Daimiel, Lidia ; Ros, Emilio ; Jenkins, David J.A. ; Toledo, Estefania ; Sorlí, José V. ; Castañer, Olga ; Abete, Itziar ; Rodriguez, Anai Moreno ; Barceló, Olga Fernández ; Oncina-Canovas, Alejandro ; Konieczna, Jadwiga ; Garcia-Rios, Antonio ; Casas, Rosa ; Gómez-Pérez, Ana Maria ; Santos-Lozano, José Manuel ; Vazquez-Ruiz, Zenaida ; Portolés, Olga ; Schröder, Helmut ; Zulet, Maria A. ; Eguaras, Sonia ; Lete, Itziar Salaverria ; Zomeño, María Dolores ; Sievenpiper, John L. ; Salas-Salvadó, Jordi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c433t-e744d8387433164d15c39f22d6e14d41ceb7ee7b08cb86d6f169b608fab55eb13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>age</topic><topic>body mass index</topic><topic>Cardiometabolic risk</topic><topic>clinical nutrition</topic><topic>clinical trials</topic><topic>DASH diet</topic><topic>diastolic blood pressure</topic><topic>Dietary Approaches to Stop Hypertension diet</topic><topic>Dietary patterns</topic><topic>food frequency questionnaires</topic><topic>glucose</topic><topic>high density lipoprotein cholesterol</topic><topic>hypertension</topic><topic>longitudinal studies</topic><topic>Metabolic syndrome</topic><topic>obesity</topic><topic>population</topic><topic>PORTFOLIO diet</topic><topic>PREDIMED-Plus trial</topic><topic>risk</topic><topic>risk reduction</topic><topic>Spain</topic><topic>systolic blood pressure</topic><topic>waist circumference</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Glenn, Andrea J.</creatorcontrib><creatorcontrib>Hernández-Alonso, Pablo</creatorcontrib><creatorcontrib>Kendall, Cyril W.C.</creatorcontrib><creatorcontrib>Martínez-González, Miguel Ángel</creatorcontrib><creatorcontrib>Corella, Dolores</creatorcontrib><creatorcontrib>Fitó, Montserrat</creatorcontrib><creatorcontrib>Martínez, J.Alfredo</creatorcontrib><creatorcontrib>Alonso-Gómez, Ángel M.</creatorcontrib><creatorcontrib>Wärnberg, Julia</creatorcontrib><creatorcontrib>Vioque, Jesús</creatorcontrib><creatorcontrib>Romaguera, Dora</creatorcontrib><creatorcontrib>López-Miranda, José</creatorcontrib><creatorcontrib>Estruch, Ramon</creatorcontrib><creatorcontrib>Tinahones, Francisco J.</creatorcontrib><creatorcontrib>Lapetra, José</creatorcontrib><creatorcontrib>Serra-Majem, J. Luís</creatorcontrib><creatorcontrib>Bueno-Cavanillas, Aurora</creatorcontrib><creatorcontrib>Tur, Josep A.</creatorcontrib><creatorcontrib>Celada, Sofia Reguero</creatorcontrib><creatorcontrib>Pintó, Xavier</creatorcontrib><creatorcontrib>Delgado-Rodríguez, Miguel</creatorcontrib><creatorcontrib>Matía-Martín, Pilar</creatorcontrib><creatorcontrib>Vidal, Josep</creatorcontrib><creatorcontrib>Mas-Fontao, Sebastian</creatorcontrib><creatorcontrib>Daimiel, Lidia</creatorcontrib><creatorcontrib>Ros, Emilio</creatorcontrib><creatorcontrib>Jenkins, David J.A.</creatorcontrib><creatorcontrib>Toledo, Estefania</creatorcontrib><creatorcontrib>Sorlí, José V.</creatorcontrib><creatorcontrib>Castañer, Olga</creatorcontrib><creatorcontrib>Abete, Itziar</creatorcontrib><creatorcontrib>Rodriguez, Anai Moreno</creatorcontrib><creatorcontrib>Barceló, Olga Fernández</creatorcontrib><creatorcontrib>Oncina-Canovas, Alejandro</creatorcontrib><creatorcontrib>Konieczna, Jadwiga</creatorcontrib><creatorcontrib>Garcia-Rios, Antonio</creatorcontrib><creatorcontrib>Casas, Rosa</creatorcontrib><creatorcontrib>Gómez-Pérez, Ana Maria</creatorcontrib><creatorcontrib>Santos-Lozano, José Manuel</creatorcontrib><creatorcontrib>Vazquez-Ruiz, Zenaida</creatorcontrib><creatorcontrib>Portolés, Olga</creatorcontrib><creatorcontrib>Schröder, Helmut</creatorcontrib><creatorcontrib>Zulet, Maria A.</creatorcontrib><creatorcontrib>Eguaras, Sonia</creatorcontrib><creatorcontrib>Lete, Itziar Salaverria</creatorcontrib><creatorcontrib>Zomeño, María Dolores</creatorcontrib><creatorcontrib>Sievenpiper, John L.</creatorcontrib><creatorcontrib>Salas-Salvadó, Jordi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Clinical nutrition (Edinburgh, Scotland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Glenn, Andrea J.</au><au>Hernández-Alonso, Pablo</au><au>Kendall, Cyril W.C.</au><au>Martínez-González, Miguel Ángel</au><au>Corella, Dolores</au><au>Fitó, Montserrat</au><au>Martínez, J.Alfredo</au><au>Alonso-Gómez, Ángel M.</au><au>Wärnberg, Julia</au><au>Vioque, Jesús</au><au>Romaguera, Dora</au><au>López-Miranda, José</au><au>Estruch, Ramon</au><au>Tinahones, Francisco J.</au><au>Lapetra, José</au><au>Serra-Majem, J. Luís</au><au>Bueno-Cavanillas, Aurora</au><au>Tur, Josep A.</au><au>Celada, Sofia Reguero</au><au>Pintó, Xavier</au><au>Delgado-Rodríguez, Miguel</au><au>Matía-Martín, Pilar</au><au>Vidal, Josep</au><au>Mas-Fontao, Sebastian</au><au>Daimiel, Lidia</au><au>Ros, Emilio</au><au>Jenkins, David J.A.</au><au>Toledo, Estefania</au><au>Sorlí, José V.</au><au>Castañer, Olga</au><au>Abete, Itziar</au><au>Rodriguez, Anai Moreno</au><au>Barceló, Olga Fernández</au><au>Oncina-Canovas, Alejandro</au><au>Konieczna, Jadwiga</au><au>Garcia-Rios, Antonio</au><au>Casas, Rosa</au><au>Gómez-Pérez, Ana Maria</au><au>Santos-Lozano, José Manuel</au><au>Vazquez-Ruiz, Zenaida</au><au>Portolés, Olga</au><au>Schröder, Helmut</au><au>Zulet, Maria A.</au><au>Eguaras, Sonia</au><au>Lete, Itziar Salaverria</au><au>Zomeño, María Dolores</au><au>Sievenpiper, John L.</au><au>Salas-Salvadó, Jordi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longitudinal changes in adherence to the portfolio and DASH dietary patterns and cardiometabolic risk factors in the PREDIMED-Plus study</atitle><jtitle>Clinical nutrition (Edinburgh, Scotland)</jtitle><addtitle>Clin Nutr</addtitle><date>2021-05-01</date><risdate>2021</risdate><volume>40</volume><issue>5</issue><spage>2825</spage><epage>2836</epage><pages>2825-2836</pages><issn>0261-5614</issn><eissn>1532-1983</eissn><abstract><![CDATA[The Portfolio and Dietary Approaches to Stop Hypertension (DASH) diets have been shown to lower cardiometabolic risk factors in randomized controlled trials (RCTs). However, the Portfolio diet has only been assessed in RCTs of hyperlipidemic patients. Therefore, to assess the Portfolio diet in a population with metabolic syndrome (MetS), we conducted a longitudinal analysis of one-year data of changes in the Portfolio and DASH diet scores and their association with cardiometabolic risk factors in Prevención con Dieta Mediterránea (PREDIMED)-Plus trial.
PREDIMED-Plus is an ongoing clinical trial (Trial registration: ISRCTN89898) conducted in Spain that includes 6874 older participants (mean age 65 y, 48% women) with overweight/obesity fulfilling at least three criteria for MetS. Data for this analysis were collected at baseline, six months and one year. Adherence to the Portfolio and DASH diet scores were derived from a validated 143-item food frequency questionnaire. We used linear mixed models to examine the associations of 1-SD increase and quartile changes in the diet scores with concomitant changes in cardiometabolic risk factors.
After adjusting for several potential confounders, a 1-SD increase in the Portfolio diet score was significantly associated with lower HbA1c (β [95% CI]: −0.02% [−0.02, −0.01], P < 0.001), fasting glucose (−0.47 mg/dL [−0.83, −0.11], P = 0.01), triglycerides (−1.29 mg/dL [−2.31, −0.28], P = 0.01), waist circumference (WC) (−0.51 cm [−0.59, −0.43], P < 0.001), and body mass index (BMI) (−0.17 kg/m2 [−0.19, −0.15], P < 0.001). A 1-SD increase in the DASH diet score was significantly associated with lower HbA1c (−0.03% [−0.04, −0.02], P < 0.001), glucose (−0.84 mg/dL [−1.18, −0.51], P < 0.001), triglycerides (−3.38 mg/dL [−4.37, −2.38], P < 0.001), non-HDL-cholesterol (−0.47 mg/dL [−0.91, −0.04], P = 0.03), WC (−0.69 cm [−0.76, −0.60 cm], P < 0.001), BMI (−0.25 kg/m2 [−0.28, −0.26 kg/m2], P < 0.001), systolic blood pressure (−0.57 mmHg [−0.81, −0.32 mmHg], P < 0.001), diastolic blood pressure (−0.15 mmHg [−0.29, −0.01 mmHg], P = 0.03), and with higher HDL-cholesterol (0.21 mg/dL [0.09, 0.34 mg/dL, P = 0.001]). Similar associations were seen when both diet scores were assessed as quartiles, comparing extreme categories of adherence.
Among older adults at high cardiovascular risk with MetS, greater adherence to the Portfolio and DASH diets showed significant favourable prospective associations with several clinically relevant cardiometabolic risk factors. Both diets are likely beneficial for cardiometabolic risk reduction.]]></abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>33933749</pmid><doi>10.1016/j.clnu.2021.03.016</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-0211-9166</orcidid><orcidid>https://orcid.org/0000-0002-0649-3016</orcidid><orcidid>https://orcid.org/0000-0002-6940-0761</orcidid><orcidid>https://orcid.org/0000-0001-9898-6629</orcidid><orcidid>https://orcid.org/0000-0002-3270-5772</orcidid><orcidid>https://orcid.org/0000-0001-6604-3327</orcidid><orcidid>https://orcid.org/0000-0001-6286-964X</orcidid><orcidid>https://orcid.org/0000-0002-6828-9627</orcidid><orcidid>https://orcid.org/0000-0002-3926-0892</orcidid><orcidid>https://orcid.org/0000-0002-2947-1338</orcidid><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0261-5614 |
ispartof | Clinical nutrition (Edinburgh, Scotland), 2021-05, Vol.40 (5), p.2825-2836 |
issn | 0261-5614 1532-1983 |
language | eng |
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source | Elsevier ScienceDirect Journals |
subjects | age body mass index Cardiometabolic risk clinical nutrition clinical trials DASH diet diastolic blood pressure Dietary Approaches to Stop Hypertension diet Dietary patterns food frequency questionnaires glucose high density lipoprotein cholesterol hypertension longitudinal studies Metabolic syndrome obesity population PORTFOLIO diet PREDIMED-Plus trial risk risk reduction Spain systolic blood pressure waist circumference |
title | Longitudinal changes in adherence to the portfolio and DASH dietary patterns and cardiometabolic risk factors in the PREDIMED-Plus study |
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