Longitudinal changes in adherence to the portfolio and DASH dietary patterns and cardiometabolic risk factors in the PREDIMED-Plus study

The Portfolio and Dietary Approaches to Stop Hypertension (DASH) diets have been shown to lower cardiometabolic risk factors in randomized controlled trials (RCTs). However, the Portfolio diet has only been assessed in RCTs of hyperlipidemic patients. Therefore, to assess the Portfolio diet in a pop...

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Veröffentlicht in:Clinical nutrition (Edinburgh, Scotland) Scotland), 2021-05, Vol.40 (5), p.2825-2836
Hauptverfasser: Glenn, Andrea J., Hernández-Alonso, Pablo, Kendall, Cyril W.C., Martínez-González, Miguel Ángel, Corella, Dolores, Fitó, Montserrat, Martínez, J.Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J., Lapetra, José, Serra-Majem, J. Luís, Bueno-Cavanillas, Aurora, Tur, Josep A., Celada, Sofia Reguero, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Mas-Fontao, Sebastian, Daimiel, Lidia, Ros, Emilio, Jenkins, David J.A., Toledo, Estefania, Sorlí, José V., Castañer, Olga, Abete, Itziar, Rodriguez, Anai Moreno, Barceló, Olga Fernández, Oncina-Canovas, Alejandro, Konieczna, Jadwiga, Garcia-Rios, Antonio, Casas, Rosa, Gómez-Pérez, Ana Maria, Santos-Lozano, José Manuel, Vazquez-Ruiz, Zenaida, Portolés, Olga, Schröder, Helmut, Zulet, Maria A., Eguaras, Sonia, Lete, Itziar Salaverria, Zomeño, María Dolores, Sievenpiper, John L., Salas-Salvadó, Jordi
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container_issue 5
container_start_page 2825
container_title Clinical nutrition (Edinburgh, Scotland)
container_volume 40
creator Glenn, Andrea J.
Hernández-Alonso, Pablo
Kendall, Cyril W.C.
Martínez-González, Miguel Ángel
Corella, Dolores
Fitó, Montserrat
Martínez, J.Alfredo
Alonso-Gómez, Ángel M.
Wärnberg, Julia
Vioque, Jesús
Romaguera, Dora
López-Miranda, José
Estruch, Ramon
Tinahones, Francisco J.
Lapetra, José
Serra-Majem, J. Luís
Bueno-Cavanillas, Aurora
Tur, Josep A.
Celada, Sofia Reguero
Pintó, Xavier
Delgado-Rodríguez, Miguel
Matía-Martín, Pilar
Vidal, Josep
Mas-Fontao, Sebastian
Daimiel, Lidia
Ros, Emilio
Jenkins, David J.A.
Toledo, Estefania
Sorlí, José V.
Castañer, Olga
Abete, Itziar
Rodriguez, Anai Moreno
Barceló, Olga Fernández
Oncina-Canovas, Alejandro
Konieczna, Jadwiga
Garcia-Rios, Antonio
Casas, Rosa
Gómez-Pérez, Ana Maria
Santos-Lozano, José Manuel
Vazquez-Ruiz, Zenaida
Portolés, Olga
Schröder, Helmut
Zulet, Maria A.
Eguaras, Sonia
Lete, Itziar Salaverria
Zomeño, María Dolores
Sievenpiper, John L.
Salas-Salvadó, Jordi
description The Portfolio and Dietary Approaches to Stop Hypertension (DASH) diets have been shown to lower cardiometabolic risk factors in randomized controlled trials (RCTs). However, the Portfolio diet has only been assessed in RCTs of hyperlipidemic patients. Therefore, to assess the Portfolio diet in a population with metabolic syndrome (MetS), we conducted a longitudinal analysis of one-year data of changes in the Portfolio and DASH diet scores and their association with cardiometabolic risk factors in Prevención con Dieta Mediterránea (PREDIMED)-Plus trial. PREDIMED-Plus is an ongoing clinical trial (Trial registration: ISRCTN89898) conducted in Spain that includes 6874 older participants (mean age 65 y, 48% women) with overweight/obesity fulfilling at least three criteria for MetS. Data for this analysis were collected at baseline, six months and one year. Adherence to the Portfolio and DASH diet scores were derived from a validated 143-item food frequency questionnaire. We used linear mixed models to examine the associations of 1-SD increase and quartile changes in the diet scores with concomitant changes in cardiometabolic risk factors. After adjusting for several potential confounders, a 1-SD increase in the Portfolio diet score was significantly associated with lower HbA1c (β [95% CI]: −0.02% [−0.02, −0.01], P 
doi_str_mv 10.1016/j.clnu.2021.03.016
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Luís ; Bueno-Cavanillas, Aurora ; Tur, Josep A. ; Celada, Sofia Reguero ; Pintó, Xavier ; Delgado-Rodríguez, Miguel ; Matía-Martín, Pilar ; Vidal, Josep ; Mas-Fontao, Sebastian ; Daimiel, Lidia ; Ros, Emilio ; Jenkins, David J.A. ; Toledo, Estefania ; Sorlí, José V. ; Castañer, Olga ; Abete, Itziar ; Rodriguez, Anai Moreno ; Barceló, Olga Fernández ; Oncina-Canovas, Alejandro ; Konieczna, Jadwiga ; Garcia-Rios, Antonio ; Casas, Rosa ; Gómez-Pérez, Ana Maria ; Santos-Lozano, José Manuel ; Vazquez-Ruiz, Zenaida ; Portolés, Olga ; Schröder, Helmut ; Zulet, Maria A. ; Eguaras, Sonia ; Lete, Itziar Salaverria ; Zomeño, María Dolores ; Sievenpiper, John L. ; Salas-Salvadó, Jordi</creator><creatorcontrib>Glenn, Andrea J. ; Hernández-Alonso, Pablo ; Kendall, Cyril W.C. ; Martínez-González, Miguel Ángel ; Corella, Dolores ; Fitó, Montserrat ; Martínez, J.Alfredo ; Alonso-Gómez, Ángel M. ; Wärnberg, Julia ; Vioque, Jesús ; Romaguera, Dora ; López-Miranda, José ; Estruch, Ramon ; Tinahones, Francisco J. ; Lapetra, José ; Serra-Majem, J. Luís ; Bueno-Cavanillas, Aurora ; Tur, Josep A. ; Celada, Sofia Reguero ; Pintó, Xavier ; Delgado-Rodríguez, Miguel ; Matía-Martín, Pilar ; Vidal, Josep ; Mas-Fontao, Sebastian ; Daimiel, Lidia ; Ros, Emilio ; Jenkins, David J.A. ; Toledo, Estefania ; Sorlí, José V. ; Castañer, Olga ; Abete, Itziar ; Rodriguez, Anai Moreno ; Barceló, Olga Fernández ; Oncina-Canovas, Alejandro ; Konieczna, Jadwiga ; Garcia-Rios, Antonio ; Casas, Rosa ; Gómez-Pérez, Ana Maria ; Santos-Lozano, José Manuel ; Vazquez-Ruiz, Zenaida ; Portolés, Olga ; Schröder, Helmut ; Zulet, Maria A. ; Eguaras, Sonia ; Lete, Itziar Salaverria ; Zomeño, María Dolores ; Sievenpiper, John L. ; Salas-Salvadó, Jordi</creatorcontrib><description><![CDATA[The Portfolio and Dietary Approaches to Stop Hypertension (DASH) diets have been shown to lower cardiometabolic risk factors in randomized controlled trials (RCTs). However, the Portfolio diet has only been assessed in RCTs of hyperlipidemic patients. Therefore, to assess the Portfolio diet in a population with metabolic syndrome (MetS), we conducted a longitudinal analysis of one-year data of changes in the Portfolio and DASH diet scores and their association with cardiometabolic risk factors in Prevención con Dieta Mediterránea (PREDIMED)-Plus trial. PREDIMED-Plus is an ongoing clinical trial (Trial registration: ISRCTN89898) conducted in Spain that includes 6874 older participants (mean age 65 y, 48% women) with overweight/obesity fulfilling at least three criteria for MetS. Data for this analysis were collected at baseline, six months and one year. Adherence to the Portfolio and DASH diet scores were derived from a validated 143-item food frequency questionnaire. We used linear mixed models to examine the associations of 1-SD increase and quartile changes in the diet scores with concomitant changes in cardiometabolic risk factors. After adjusting for several potential confounders, a 1-SD increase in the Portfolio diet score was significantly associated with lower HbA1c (β [95% CI]: −0.02% [−0.02, −0.01], P < 0.001), fasting glucose (−0.47 mg/dL [−0.83, −0.11], P = 0.01), triglycerides (−1.29 mg/dL [−2.31, −0.28], P = 0.01), waist circumference (WC) (−0.51 cm [−0.59, −0.43], P < 0.001), and body mass index (BMI) (−0.17 kg/m2 [−0.19, −0.15], P < 0.001). A 1-SD increase in the DASH diet score was significantly associated with lower HbA1c (−0.03% [−0.04, −0.02], P < 0.001), glucose (−0.84 mg/dL [−1.18, −0.51], P < 0.001), triglycerides (−3.38 mg/dL [−4.37, −2.38], P < 0.001), non-HDL-cholesterol (−0.47 mg/dL [−0.91, −0.04], P = 0.03), WC (−0.69 cm [−0.76, −0.60 cm], P < 0.001), BMI (−0.25 kg/m2 [−0.28, −0.26 kg/m2], P < 0.001), systolic blood pressure (−0.57 mmHg [−0.81, −0.32 mmHg], P < 0.001), diastolic blood pressure (−0.15 mmHg [−0.29, −0.01 mmHg], P = 0.03), and with higher HDL-cholesterol (0.21 mg/dL [0.09, 0.34 mg/dL, P = 0.001]). Similar associations were seen when both diet scores were assessed as quartiles, comparing extreme categories of adherence. Among older adults at high cardiovascular risk with MetS, greater adherence to the Portfolio and DASH diets showed significant favourable prospective associations with several clinically relevant cardiometabolic risk factors. Both diets are likely beneficial for cardiometabolic risk reduction.]]></description><identifier>ISSN: 0261-5614</identifier><identifier>EISSN: 1532-1983</identifier><identifier>DOI: 10.1016/j.clnu.2021.03.016</identifier><identifier>PMID: 33933749</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>age ; body mass index ; Cardiometabolic risk ; clinical nutrition ; clinical trials ; DASH diet ; diastolic blood pressure ; Dietary Approaches to Stop Hypertension diet ; Dietary patterns ; food frequency questionnaires ; glucose ; high density lipoprotein cholesterol ; hypertension ; longitudinal studies ; Metabolic syndrome ; obesity ; population ; PORTFOLIO diet ; PREDIMED-Plus trial ; risk ; risk reduction ; Spain ; systolic blood pressure ; waist circumference</subject><ispartof>Clinical nutrition (Edinburgh, Scotland), 2021-05, Vol.40 (5), p.2825-2836</ispartof><rights>2021 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism</rights><rights>Copyright © 2021 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c433t-e744d8387433164d15c39f22d6e14d41ceb7ee7b08cb86d6f169b608fab55eb13</citedby><cites>FETCH-LOGICAL-c433t-e744d8387433164d15c39f22d6e14d41ceb7ee7b08cb86d6f169b608fab55eb13</cites><orcidid>0000-0002-0211-9166 ; 0000-0002-0649-3016 ; 0000-0002-6940-0761 ; 0000-0001-9898-6629 ; 0000-0002-3270-5772 ; 0000-0001-6604-3327 ; 0000-0001-6286-964X ; 0000-0002-6828-9627 ; 0000-0002-3926-0892 ; 0000-0002-2947-1338</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0261561421001552$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33933749$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Glenn, Andrea J.</creatorcontrib><creatorcontrib>Hernández-Alonso, Pablo</creatorcontrib><creatorcontrib>Kendall, Cyril W.C.</creatorcontrib><creatorcontrib>Martínez-González, Miguel Ángel</creatorcontrib><creatorcontrib>Corella, Dolores</creatorcontrib><creatorcontrib>Fitó, Montserrat</creatorcontrib><creatorcontrib>Martínez, J.Alfredo</creatorcontrib><creatorcontrib>Alonso-Gómez, Ángel M.</creatorcontrib><creatorcontrib>Wärnberg, Julia</creatorcontrib><creatorcontrib>Vioque, Jesús</creatorcontrib><creatorcontrib>Romaguera, Dora</creatorcontrib><creatorcontrib>López-Miranda, José</creatorcontrib><creatorcontrib>Estruch, Ramon</creatorcontrib><creatorcontrib>Tinahones, Francisco J.</creatorcontrib><creatorcontrib>Lapetra, José</creatorcontrib><creatorcontrib>Serra-Majem, J. Luís</creatorcontrib><creatorcontrib>Bueno-Cavanillas, Aurora</creatorcontrib><creatorcontrib>Tur, Josep A.</creatorcontrib><creatorcontrib>Celada, Sofia Reguero</creatorcontrib><creatorcontrib>Pintó, Xavier</creatorcontrib><creatorcontrib>Delgado-Rodríguez, Miguel</creatorcontrib><creatorcontrib>Matía-Martín, Pilar</creatorcontrib><creatorcontrib>Vidal, Josep</creatorcontrib><creatorcontrib>Mas-Fontao, Sebastian</creatorcontrib><creatorcontrib>Daimiel, Lidia</creatorcontrib><creatorcontrib>Ros, Emilio</creatorcontrib><creatorcontrib>Jenkins, David J.A.</creatorcontrib><creatorcontrib>Toledo, Estefania</creatorcontrib><creatorcontrib>Sorlí, José V.</creatorcontrib><creatorcontrib>Castañer, Olga</creatorcontrib><creatorcontrib>Abete, Itziar</creatorcontrib><creatorcontrib>Rodriguez, Anai Moreno</creatorcontrib><creatorcontrib>Barceló, Olga Fernández</creatorcontrib><creatorcontrib>Oncina-Canovas, Alejandro</creatorcontrib><creatorcontrib>Konieczna, Jadwiga</creatorcontrib><creatorcontrib>Garcia-Rios, Antonio</creatorcontrib><creatorcontrib>Casas, Rosa</creatorcontrib><creatorcontrib>Gómez-Pérez, Ana Maria</creatorcontrib><creatorcontrib>Santos-Lozano, José Manuel</creatorcontrib><creatorcontrib>Vazquez-Ruiz, Zenaida</creatorcontrib><creatorcontrib>Portolés, Olga</creatorcontrib><creatorcontrib>Schröder, Helmut</creatorcontrib><creatorcontrib>Zulet, Maria A.</creatorcontrib><creatorcontrib>Eguaras, Sonia</creatorcontrib><creatorcontrib>Lete, Itziar Salaverria</creatorcontrib><creatorcontrib>Zomeño, María Dolores</creatorcontrib><creatorcontrib>Sievenpiper, John L.</creatorcontrib><creatorcontrib>Salas-Salvadó, Jordi</creatorcontrib><title>Longitudinal changes in adherence to the portfolio and DASH dietary patterns and cardiometabolic risk factors in the PREDIMED-Plus study</title><title>Clinical nutrition (Edinburgh, Scotland)</title><addtitle>Clin Nutr</addtitle><description><![CDATA[The Portfolio and Dietary Approaches to Stop Hypertension (DASH) diets have been shown to lower cardiometabolic risk factors in randomized controlled trials (RCTs). However, the Portfolio diet has only been assessed in RCTs of hyperlipidemic patients. Therefore, to assess the Portfolio diet in a population with metabolic syndrome (MetS), we conducted a longitudinal analysis of one-year data of changes in the Portfolio and DASH diet scores and their association with cardiometabolic risk factors in Prevención con Dieta Mediterránea (PREDIMED)-Plus trial. PREDIMED-Plus is an ongoing clinical trial (Trial registration: ISRCTN89898) conducted in Spain that includes 6874 older participants (mean age 65 y, 48% women) with overweight/obesity fulfilling at least three criteria for MetS. Data for this analysis were collected at baseline, six months and one year. Adherence to the Portfolio and DASH diet scores were derived from a validated 143-item food frequency questionnaire. We used linear mixed models to examine the associations of 1-SD increase and quartile changes in the diet scores with concomitant changes in cardiometabolic risk factors. After adjusting for several potential confounders, a 1-SD increase in the Portfolio diet score was significantly associated with lower HbA1c (β [95% CI]: −0.02% [−0.02, −0.01], P < 0.001), fasting glucose (−0.47 mg/dL [−0.83, −0.11], P = 0.01), triglycerides (−1.29 mg/dL [−2.31, −0.28], P = 0.01), waist circumference (WC) (−0.51 cm [−0.59, −0.43], P < 0.001), and body mass index (BMI) (−0.17 kg/m2 [−0.19, −0.15], P < 0.001). A 1-SD increase in the DASH diet score was significantly associated with lower HbA1c (−0.03% [−0.04, −0.02], P < 0.001), glucose (−0.84 mg/dL [−1.18, −0.51], P < 0.001), triglycerides (−3.38 mg/dL [−4.37, −2.38], P < 0.001), non-HDL-cholesterol (−0.47 mg/dL [−0.91, −0.04], P = 0.03), WC (−0.69 cm [−0.76, −0.60 cm], P < 0.001), BMI (−0.25 kg/m2 [−0.28, −0.26 kg/m2], P < 0.001), systolic blood pressure (−0.57 mmHg [−0.81, −0.32 mmHg], P < 0.001), diastolic blood pressure (−0.15 mmHg [−0.29, −0.01 mmHg], P = 0.03), and with higher HDL-cholesterol (0.21 mg/dL [0.09, 0.34 mg/dL, P = 0.001]). Similar associations were seen when both diet scores were assessed as quartiles, comparing extreme categories of adherence. Among older adults at high cardiovascular risk with MetS, greater adherence to the Portfolio and DASH diets showed significant favourable prospective associations with several clinically relevant cardiometabolic risk factors. Both diets are likely beneficial for cardiometabolic risk reduction.]]></description><subject>age</subject><subject>body mass index</subject><subject>Cardiometabolic risk</subject><subject>clinical nutrition</subject><subject>clinical trials</subject><subject>DASH diet</subject><subject>diastolic blood pressure</subject><subject>Dietary Approaches to Stop Hypertension diet</subject><subject>Dietary patterns</subject><subject>food frequency questionnaires</subject><subject>glucose</subject><subject>high density lipoprotein cholesterol</subject><subject>hypertension</subject><subject>longitudinal studies</subject><subject>Metabolic syndrome</subject><subject>obesity</subject><subject>population</subject><subject>PORTFOLIO diet</subject><subject>PREDIMED-Plus trial</subject><subject>risk</subject><subject>risk reduction</subject><subject>Spain</subject><subject>systolic blood pressure</subject><subject>waist circumference</subject><issn>0261-5614</issn><issn>1532-1983</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqNkc9u1DAQxi0EosvCC3BAPnJJ6n9xEolL1V1opa1aFThbjj3pesnGi-1U6hvw2DjdlmPFZayZ-eZn6fsQ-khJSQmVp7vSDONUMsJoSXiZR6_QglacFbRt-Gu0IEzSopJUnKB3Me4IIRWvm7fohPOW81q0C_Rn48c7lybrRj1gs9XjHUTsRqztFgKMBnDyOG0BH3xIvR-cx3q0eHX2_QJbB0mHB3zQKUEY4-PG6GCd3-dNl9UGBxd_4V6b5MMjeGbd3K5Xl1frVXEzTBHH_P3De_Sm10OED0_vEv38uv5xflFsrr9dnp9tCiM4TwXUQtiGN3XuqBSWVoa3PWNWAhVWUANdDVB3pDFdI63sqWw7SZped1UFHeVL9PnIPQT_e4KY1N5FA8OgR_BTVKxiGd3IXP9DSkXLaTZzidhRaoKPMUCvDsHtszeKEjWHpXZqDkvNYSnCVR7lo09P_Knbg_138pxOFnw5CiAbcu8gqGjcnIl1AUxS1ruX-H8BimKmXw</recordid><startdate>20210501</startdate><enddate>20210501</enddate><creator>Glenn, Andrea J.</creator><creator>Hernández-Alonso, Pablo</creator><creator>Kendall, Cyril W.C.</creator><creator>Martínez-González, Miguel Ángel</creator><creator>Corella, Dolores</creator><creator>Fitó, Montserrat</creator><creator>Martínez, J.Alfredo</creator><creator>Alonso-Gómez, Ángel M.</creator><creator>Wärnberg, Julia</creator><creator>Vioque, Jesús</creator><creator>Romaguera, Dora</creator><creator>López-Miranda, José</creator><creator>Estruch, Ramon</creator><creator>Tinahones, Francisco J.</creator><creator>Lapetra, José</creator><creator>Serra-Majem, J. 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Luís ; Bueno-Cavanillas, Aurora ; Tur, Josep A. ; Celada, Sofia Reguero ; Pintó, Xavier ; Delgado-Rodríguez, Miguel ; Matía-Martín, Pilar ; Vidal, Josep ; Mas-Fontao, Sebastian ; Daimiel, Lidia ; Ros, Emilio ; Jenkins, David J.A. ; Toledo, Estefania ; Sorlí, José V. ; Castañer, Olga ; Abete, Itziar ; Rodriguez, Anai Moreno ; Barceló, Olga Fernández ; Oncina-Canovas, Alejandro ; Konieczna, Jadwiga ; Garcia-Rios, Antonio ; Casas, Rosa ; Gómez-Pérez, Ana Maria ; Santos-Lozano, José Manuel ; Vazquez-Ruiz, Zenaida ; Portolés, Olga ; Schröder, Helmut ; Zulet, Maria A. ; Eguaras, Sonia ; Lete, Itziar Salaverria ; Zomeño, María Dolores ; Sievenpiper, John L. ; Salas-Salvadó, Jordi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c433t-e744d8387433164d15c39f22d6e14d41ceb7ee7b08cb86d6f169b608fab55eb13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>age</topic><topic>body mass index</topic><topic>Cardiometabolic risk</topic><topic>clinical nutrition</topic><topic>clinical trials</topic><topic>DASH diet</topic><topic>diastolic blood pressure</topic><topic>Dietary Approaches to Stop Hypertension diet</topic><topic>Dietary patterns</topic><topic>food frequency questionnaires</topic><topic>glucose</topic><topic>high density lipoprotein cholesterol</topic><topic>hypertension</topic><topic>longitudinal studies</topic><topic>Metabolic syndrome</topic><topic>obesity</topic><topic>population</topic><topic>PORTFOLIO diet</topic><topic>PREDIMED-Plus trial</topic><topic>risk</topic><topic>risk reduction</topic><topic>Spain</topic><topic>systolic blood pressure</topic><topic>waist circumference</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Glenn, Andrea J.</creatorcontrib><creatorcontrib>Hernández-Alonso, Pablo</creatorcontrib><creatorcontrib>Kendall, Cyril W.C.</creatorcontrib><creatorcontrib>Martínez-González, Miguel Ángel</creatorcontrib><creatorcontrib>Corella, Dolores</creatorcontrib><creatorcontrib>Fitó, Montserrat</creatorcontrib><creatorcontrib>Martínez, J.Alfredo</creatorcontrib><creatorcontrib>Alonso-Gómez, Ángel M.</creatorcontrib><creatorcontrib>Wärnberg, Julia</creatorcontrib><creatorcontrib>Vioque, Jesús</creatorcontrib><creatorcontrib>Romaguera, Dora</creatorcontrib><creatorcontrib>López-Miranda, José</creatorcontrib><creatorcontrib>Estruch, Ramon</creatorcontrib><creatorcontrib>Tinahones, Francisco J.</creatorcontrib><creatorcontrib>Lapetra, José</creatorcontrib><creatorcontrib>Serra-Majem, J. Luís</creatorcontrib><creatorcontrib>Bueno-Cavanillas, Aurora</creatorcontrib><creatorcontrib>Tur, Josep A.</creatorcontrib><creatorcontrib>Celada, Sofia Reguero</creatorcontrib><creatorcontrib>Pintó, Xavier</creatorcontrib><creatorcontrib>Delgado-Rodríguez, Miguel</creatorcontrib><creatorcontrib>Matía-Martín, Pilar</creatorcontrib><creatorcontrib>Vidal, Josep</creatorcontrib><creatorcontrib>Mas-Fontao, Sebastian</creatorcontrib><creatorcontrib>Daimiel, Lidia</creatorcontrib><creatorcontrib>Ros, Emilio</creatorcontrib><creatorcontrib>Jenkins, David J.A.</creatorcontrib><creatorcontrib>Toledo, Estefania</creatorcontrib><creatorcontrib>Sorlí, José V.</creatorcontrib><creatorcontrib>Castañer, Olga</creatorcontrib><creatorcontrib>Abete, Itziar</creatorcontrib><creatorcontrib>Rodriguez, Anai Moreno</creatorcontrib><creatorcontrib>Barceló, Olga Fernández</creatorcontrib><creatorcontrib>Oncina-Canovas, Alejandro</creatorcontrib><creatorcontrib>Konieczna, Jadwiga</creatorcontrib><creatorcontrib>Garcia-Rios, Antonio</creatorcontrib><creatorcontrib>Casas, Rosa</creatorcontrib><creatorcontrib>Gómez-Pérez, Ana Maria</creatorcontrib><creatorcontrib>Santos-Lozano, José Manuel</creatorcontrib><creatorcontrib>Vazquez-Ruiz, Zenaida</creatorcontrib><creatorcontrib>Portolés, Olga</creatorcontrib><creatorcontrib>Schröder, Helmut</creatorcontrib><creatorcontrib>Zulet, Maria A.</creatorcontrib><creatorcontrib>Eguaras, Sonia</creatorcontrib><creatorcontrib>Lete, Itziar Salaverria</creatorcontrib><creatorcontrib>Zomeño, María Dolores</creatorcontrib><creatorcontrib>Sievenpiper, John L.</creatorcontrib><creatorcontrib>Salas-Salvadó, Jordi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Clinical nutrition (Edinburgh, Scotland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Glenn, Andrea J.</au><au>Hernández-Alonso, Pablo</au><au>Kendall, Cyril W.C.</au><au>Martínez-González, Miguel Ángel</au><au>Corella, Dolores</au><au>Fitó, Montserrat</au><au>Martínez, J.Alfredo</au><au>Alonso-Gómez, Ángel M.</au><au>Wärnberg, Julia</au><au>Vioque, Jesús</au><au>Romaguera, Dora</au><au>López-Miranda, José</au><au>Estruch, Ramon</au><au>Tinahones, Francisco J.</au><au>Lapetra, José</au><au>Serra-Majem, J. Luís</au><au>Bueno-Cavanillas, Aurora</au><au>Tur, Josep A.</au><au>Celada, Sofia Reguero</au><au>Pintó, Xavier</au><au>Delgado-Rodríguez, Miguel</au><au>Matía-Martín, Pilar</au><au>Vidal, Josep</au><au>Mas-Fontao, Sebastian</au><au>Daimiel, Lidia</au><au>Ros, Emilio</au><au>Jenkins, David J.A.</au><au>Toledo, Estefania</au><au>Sorlí, José V.</au><au>Castañer, Olga</au><au>Abete, Itziar</au><au>Rodriguez, Anai Moreno</au><au>Barceló, Olga Fernández</au><au>Oncina-Canovas, Alejandro</au><au>Konieczna, Jadwiga</au><au>Garcia-Rios, Antonio</au><au>Casas, Rosa</au><au>Gómez-Pérez, Ana Maria</au><au>Santos-Lozano, José Manuel</au><au>Vazquez-Ruiz, Zenaida</au><au>Portolés, Olga</au><au>Schröder, Helmut</au><au>Zulet, Maria A.</au><au>Eguaras, Sonia</au><au>Lete, Itziar Salaverria</au><au>Zomeño, María Dolores</au><au>Sievenpiper, John L.</au><au>Salas-Salvadó, Jordi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longitudinal changes in adherence to the portfolio and DASH dietary patterns and cardiometabolic risk factors in the PREDIMED-Plus study</atitle><jtitle>Clinical nutrition (Edinburgh, Scotland)</jtitle><addtitle>Clin Nutr</addtitle><date>2021-05-01</date><risdate>2021</risdate><volume>40</volume><issue>5</issue><spage>2825</spage><epage>2836</epage><pages>2825-2836</pages><issn>0261-5614</issn><eissn>1532-1983</eissn><abstract><![CDATA[The Portfolio and Dietary Approaches to Stop Hypertension (DASH) diets have been shown to lower cardiometabolic risk factors in randomized controlled trials (RCTs). However, the Portfolio diet has only been assessed in RCTs of hyperlipidemic patients. Therefore, to assess the Portfolio diet in a population with metabolic syndrome (MetS), we conducted a longitudinal analysis of one-year data of changes in the Portfolio and DASH diet scores and their association with cardiometabolic risk factors in Prevención con Dieta Mediterránea (PREDIMED)-Plus trial. PREDIMED-Plus is an ongoing clinical trial (Trial registration: ISRCTN89898) conducted in Spain that includes 6874 older participants (mean age 65 y, 48% women) with overweight/obesity fulfilling at least three criteria for MetS. Data for this analysis were collected at baseline, six months and one year. Adherence to the Portfolio and DASH diet scores were derived from a validated 143-item food frequency questionnaire. We used linear mixed models to examine the associations of 1-SD increase and quartile changes in the diet scores with concomitant changes in cardiometabolic risk factors. After adjusting for several potential confounders, a 1-SD increase in the Portfolio diet score was significantly associated with lower HbA1c (β [95% CI]: −0.02% [−0.02, −0.01], P < 0.001), fasting glucose (−0.47 mg/dL [−0.83, −0.11], P = 0.01), triglycerides (−1.29 mg/dL [−2.31, −0.28], P = 0.01), waist circumference (WC) (−0.51 cm [−0.59, −0.43], P < 0.001), and body mass index (BMI) (−0.17 kg/m2 [−0.19, −0.15], P < 0.001). A 1-SD increase in the DASH diet score was significantly associated with lower HbA1c (−0.03% [−0.04, −0.02], P < 0.001), glucose (−0.84 mg/dL [−1.18, −0.51], P < 0.001), triglycerides (−3.38 mg/dL [−4.37, −2.38], P < 0.001), non-HDL-cholesterol (−0.47 mg/dL [−0.91, −0.04], P = 0.03), WC (−0.69 cm [−0.76, −0.60 cm], P < 0.001), BMI (−0.25 kg/m2 [−0.28, −0.26 kg/m2], P < 0.001), systolic blood pressure (−0.57 mmHg [−0.81, −0.32 mmHg], P < 0.001), diastolic blood pressure (−0.15 mmHg [−0.29, −0.01 mmHg], P = 0.03), and with higher HDL-cholesterol (0.21 mg/dL [0.09, 0.34 mg/dL, P = 0.001]). Similar associations were seen when both diet scores were assessed as quartiles, comparing extreme categories of adherence. Among older adults at high cardiovascular risk with MetS, greater adherence to the Portfolio and DASH diets showed significant favourable prospective associations with several clinically relevant cardiometabolic risk factors. Both diets are likely beneficial for cardiometabolic risk reduction.]]></abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>33933749</pmid><doi>10.1016/j.clnu.2021.03.016</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-0211-9166</orcidid><orcidid>https://orcid.org/0000-0002-0649-3016</orcidid><orcidid>https://orcid.org/0000-0002-6940-0761</orcidid><orcidid>https://orcid.org/0000-0001-9898-6629</orcidid><orcidid>https://orcid.org/0000-0002-3270-5772</orcidid><orcidid>https://orcid.org/0000-0001-6604-3327</orcidid><orcidid>https://orcid.org/0000-0001-6286-964X</orcidid><orcidid>https://orcid.org/0000-0002-6828-9627</orcidid><orcidid>https://orcid.org/0000-0002-3926-0892</orcidid><orcidid>https://orcid.org/0000-0002-2947-1338</orcidid><oa>free_for_read</oa></addata></record>
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identifier ISSN: 0261-5614
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issn 0261-5614
1532-1983
language eng
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source Elsevier ScienceDirect Journals
subjects age
body mass index
Cardiometabolic risk
clinical nutrition
clinical trials
DASH diet
diastolic blood pressure
Dietary Approaches to Stop Hypertension diet
Dietary patterns
food frequency questionnaires
glucose
high density lipoprotein cholesterol
hypertension
longitudinal studies
Metabolic syndrome
obesity
population
PORTFOLIO diet
PREDIMED-Plus trial
risk
risk reduction
Spain
systolic blood pressure
waist circumference
title Longitudinal changes in adherence to the portfolio and DASH dietary patterns and cardiometabolic risk factors in the PREDIMED-Plus study
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