Traumatic Brain Injury: Mechanistic Insight on Pathophysiology and Potential Therapeutic Targets

Traumatic brain injury (TBI) causes brain damage, which involves primary and secondary injury mechanisms. Primary injury causes local brain damage, while secondary damage begins with inflammatory activity followed by disruption of the blood–brain barrier (BBB), peripheral blood cells infiltration, b...

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Veröffentlicht in:	Journal of molecular neuroscience 2021-09, Vol.71 (9), p.1725-1742
Hauptverfasser:	Thapa, Komal, Khan, Heena, Singh, Thakur Gurjeet, Kaur, Amarjot
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biomedical and Life Sciences Biomedicine Blood cells Blood-brain barrier Brain damage Brain Injuries, Traumatic - drug therapy Brain Injuries, Traumatic - metabolism Cell Biology Chemical compounds Chemotactic factors Cognition Decision making Drug therapy Edema Head injuries Hemorrhage Humans Inflammation Interleukins Neurochemistry Neurology Neuroprotective Agents - therapeutic use Neurosciences NF-kappa B - metabolism Oxidative Stress Pathophysiology Peripheral blood Pharmacology Proteomics Signal Transduction Traumatic brain injury
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