Protonation State of a Histidine Residue in Human Oligopeptide Transporter 1 (hPEPT1) Regulates hPEPT1-Mediated Efflux Activity

To clarify the role of an amino acid residue in the pH-dependent efflux process in Chinese hamster ovary (CHO) cells expressing the human oligopeptide transporter hPEPT1 (CHO/hPEPT1), we determined the effect of extracellular pH on the hPEPT1-mediated efflux process. The efflux of glycylsarcosine (G...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2021/05/01, Vol.44(5), pp.678-685
Hauptverfasser:	Omori, Akiko, Fujisawa, Yuki, Sasaki, Shotaro, Shimono, Kazumi, Kikukawa, Takashi, Miyauchi, Seiji
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Chemical modification Histidine pH effects pH-dependent efflux activity proton-dependent oligopeptide transporter Protons
Online-Zugang:	Volltext
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