The material-enabled oxygen control in thiol-ene microfluidic channels and its feasibility for subcellular drug metabolism assays under hypoxia in vitro

Tissue oxygen levels are known to be critical to regulation of many cellular processes, including the hepatic metabolism of therapeutic drugs, but its impact is often ignored in in vitro assays. In this study, the material-induced oxygen scavenging property of off-stoichiometric thiol-enes (OSTE) wa...

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Veröffentlicht in:	Lab on a chip 2021-05, Vol.21 (9), p.1820-1831
Hauptverfasser:	Kiiski, Iiro, Järvinen, Päivi, Ollikainen, Elisa, Jokinen, Ville, Sikanen, Tiina
Format:	Artikel
Sprache:	eng
Schlagworte:	Depletion Hypoxia Liver Mechanical properties Metabolism Metabolites Microchannels Microfluidic devices Monomers Oxygen Scavenging flow Zidovudine
Online-Zugang:	Volltext
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