Microcirculatory Changes in Pediatric Patients During Congenital Heart Defect Corrective Surgery
A prospective, observational single-center study was carried out. Pediatric patients undergoing congenital heart defect surgery were evaluated before, during, and after surgery. At each time point, sublingual microcirculation and clinical parameters were assessed, along with analytical variables. Tw...
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| Veröffentlicht in: | Journal of cardiovascular translational research 2021-12, Vol.14 (6), p.1173-1185 |
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| creator | González Cortés, Rafael Urbano Villaescusa, Javier Solana García, María J. López González, Jorge Fernández Lafever, Sarah N. Ramírez Gómez, Blanca Fuentes Moran, José R. Hidalgo García, Irene Peleteiro Pensado, Ana Pérez-Caballero Martínez, Ramón Pardo Prado, Carlos A. Rodríguez Ogando, Alejandro López Blazquez, María López-Herce Cid, Jesús |
| description | A prospective, observational single-center study was carried out. Pediatric patients undergoing congenital heart defect surgery were evaluated before, during, and after surgery. At each time point, sublingual microcirculation and clinical parameters were assessed, along with analytical variables. Twenty-four patients were included. All microcirculatory parameters worsened during cardiopulmonary bypass and returned to baseline values after surgery (
p
≤ 0.001). In the intraoperative evaluation, body temperature correlated with perfused small vessel density (
p
= 0.014), proportion of perfused small vessels (
p
< 0.001), small vessel microvascular flow index (
p
= 0.003), and small vessel heterogeneity index (
p
< 0.002). Patients with cyanotic disease exhibited higher small vessel density (
p
< 0.008) and higher density of perfused small vessels (
p
< 0.022) at baseline, and a lower microvascular flow index (
p
= 0.022) and higher heterogeneity (
p
= 0.026) in the intraoperative phase. Children with congenital heart disease exhibited decreased vascular density and microvascular blood flow and increased heterogeneity during cardiopulmonary bypass. All these parameters returned to baseline values after surgery.
Graphical abstract |
| doi_str_mv | 10.1007/s12265-021-10132-w |
| format | Article |
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p
≤ 0.001). In the intraoperative evaluation, body temperature correlated with perfused small vessel density (
p
= 0.014), proportion of perfused small vessels (
p
< 0.001), small vessel microvascular flow index (
p
= 0.003), and small vessel heterogeneity index (
p
< 0.002). Patients with cyanotic disease exhibited higher small vessel density (
p
< 0.008) and higher density of perfused small vessels (
p
< 0.022) at baseline, and a lower microvascular flow index (
p
= 0.022) and higher heterogeneity (
p
= 0.026) in the intraoperative phase. Children with congenital heart disease exhibited decreased vascular density and microvascular blood flow and increased heterogeneity during cardiopulmonary bypass. All these parameters returned to baseline values after surgery.
Graphical abstract</description><identifier>ISSN: 1937-5387</identifier><identifier>EISSN: 1937-5395</identifier><identifier>DOI: 10.1007/s12265-021-10132-w</identifier><identifier>PMID: 33948868</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adolescent ; Biomedical Engineering and Bioengineering ; Biomedicine ; Blood Flow Velocity ; Cardiology ; Cardiopulmonary Bypass ; Child ; Child, Preschool ; Female ; Heart Defects, Congenital - surgery ; Human Genetics ; Humans ; Infant ; Intraoperative Period ; Male ; Medicine ; Medicine & Public Health ; Microcirculation ; Original Article ; Prospective Studies</subject><ispartof>Journal of cardiovascular translational research, 2021-12, Vol.14 (6), p.1173-1185</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-ee7fb3ec1edcdd0f8e817b1866c706e4cc548e01b1f94cff778c4f1a4661338f3</citedby><cites>FETCH-LOGICAL-c347t-ee7fb3ec1edcdd0f8e817b1866c706e4cc548e01b1f94cff778c4f1a4661338f3</cites><orcidid>0000-0002-3259-7898</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12265-021-10132-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12265-021-10132-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33948868$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>González Cortés, Rafael</creatorcontrib><creatorcontrib>Urbano Villaescusa, Javier</creatorcontrib><creatorcontrib>Solana García, María J.</creatorcontrib><creatorcontrib>López González, Jorge</creatorcontrib><creatorcontrib>Fernández Lafever, Sarah N.</creatorcontrib><creatorcontrib>Ramírez Gómez, Blanca</creatorcontrib><creatorcontrib>Fuentes Moran, José R.</creatorcontrib><creatorcontrib>Hidalgo García, Irene</creatorcontrib><creatorcontrib>Peleteiro Pensado, Ana</creatorcontrib><creatorcontrib>Pérez-Caballero Martínez, Ramón</creatorcontrib><creatorcontrib>Pardo Prado, Carlos A.</creatorcontrib><creatorcontrib>Rodríguez Ogando, Alejandro</creatorcontrib><creatorcontrib>López Blazquez, María</creatorcontrib><creatorcontrib>López-Herce Cid, Jesús</creatorcontrib><title>Microcirculatory Changes in Pediatric Patients During Congenital Heart Defect Corrective Surgery</title><title>Journal of cardiovascular translational research</title><addtitle>J. of Cardiovasc. Trans. Res</addtitle><addtitle>J Cardiovasc Transl Res</addtitle><description>A prospective, observational single-center study was carried out. Pediatric patients undergoing congenital heart defect surgery were evaluated before, during, and after surgery. At each time point, sublingual microcirculation and clinical parameters were assessed, along with analytical variables. Twenty-four patients were included. All microcirculatory parameters worsened during cardiopulmonary bypass and returned to baseline values after surgery (
p
≤ 0.001). In the intraoperative evaluation, body temperature correlated with perfused small vessel density (
p
= 0.014), proportion of perfused small vessels (
p
< 0.001), small vessel microvascular flow index (
p
= 0.003), and small vessel heterogeneity index (
p
< 0.002). Patients with cyanotic disease exhibited higher small vessel density (
p
< 0.008) and higher density of perfused small vessels (
p
< 0.022) at baseline, and a lower microvascular flow index (
p
= 0.022) and higher heterogeneity (
p
= 0.026) in the intraoperative phase. Children with congenital heart disease exhibited decreased vascular density and microvascular blood flow and increased heterogeneity during cardiopulmonary bypass. All these parameters returned to baseline values after surgery.
Graphical abstract</description><subject>Adolescent</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedicine</subject><subject>Blood Flow Velocity</subject><subject>Cardiology</subject><subject>Cardiopulmonary Bypass</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Heart Defects, Congenital - surgery</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Infant</subject><subject>Intraoperative Period</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microcirculation</subject><subject>Original Article</subject><subject>Prospective Studies</subject><issn>1937-5387</issn><issn>1937-5395</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtO5DAQRS3EaHjND7BAXrIJuOzEdpaoeUqMBglYe9xOuTFKJ43tgPrvx0wDS1ZVKp17pTqEHAI7AcbUaQLOZVMxDhUwELx62yK70ApVNaJttr92rXbIXkrPjEnOlPpJdoRoa62l3iV_fwcXRxeim3qbx7imsyc7LDDRMNA77ILNMTh6Z3PAISd6PsUwLOhsLMwQsu3pNdqY6Tl6dLncYywzvCK9n-IC4_qA_PC2T_jrY-6Tx8uLh9l1dfvn6mZ2dls5UatcISo_F-gAO9d1zGvUoOagpXSKSayda2qNDObg29p5r5R2tQdbSwlCaC_2yfGmdxXHlwlTNsuQHPa9HXCckuEN56KVGqCgfIOWz1OK6M0qhqWNawPMvJs1G7OmmDX_zZq3Ejr66J_mS-y-Ip8qCyA2QFq9K8JonscpDuXn72r_AWaBhj4</recordid><startdate>20211201</startdate><enddate>20211201</enddate><creator>González Cortés, Rafael</creator><creator>Urbano Villaescusa, Javier</creator><creator>Solana García, María J.</creator><creator>López González, Jorge</creator><creator>Fernández Lafever, Sarah N.</creator><creator>Ramírez Gómez, Blanca</creator><creator>Fuentes Moran, José R.</creator><creator>Hidalgo García, Irene</creator><creator>Peleteiro Pensado, Ana</creator><creator>Pérez-Caballero Martínez, Ramón</creator><creator>Pardo Prado, Carlos A.</creator><creator>Rodríguez Ogando, Alejandro</creator><creator>López Blazquez, María</creator><creator>López-Herce Cid, Jesús</creator><general>Springer US</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3259-7898</orcidid></search><sort><creationdate>20211201</creationdate><title>Microcirculatory Changes in Pediatric Patients During Congenital Heart Defect Corrective Surgery</title><author>González Cortés, Rafael ; Urbano Villaescusa, Javier ; Solana García, María J. ; López González, Jorge ; Fernández Lafever, Sarah N. ; Ramírez Gómez, Blanca ; Fuentes Moran, José R. ; Hidalgo García, Irene ; Peleteiro Pensado, Ana ; Pérez-Caballero Martínez, Ramón ; Pardo Prado, Carlos A. ; Rodríguez Ogando, Alejandro ; López Blazquez, María ; López-Herce Cid, Jesús</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-ee7fb3ec1edcdd0f8e817b1866c706e4cc548e01b1f94cff778c4f1a4661338f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescent</topic><topic>Biomedical Engineering and Bioengineering</topic><topic>Biomedicine</topic><topic>Blood Flow Velocity</topic><topic>Cardiology</topic><topic>Cardiopulmonary Bypass</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Heart Defects, Congenital - surgery</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Infant</topic><topic>Intraoperative Period</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Microcirculation</topic><topic>Original Article</topic><topic>Prospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>González Cortés, Rafael</creatorcontrib><creatorcontrib>Urbano Villaescusa, Javier</creatorcontrib><creatorcontrib>Solana García, María J.</creatorcontrib><creatorcontrib>López González, Jorge</creatorcontrib><creatorcontrib>Fernández Lafever, Sarah N.</creatorcontrib><creatorcontrib>Ramírez Gómez, Blanca</creatorcontrib><creatorcontrib>Fuentes Moran, José R.</creatorcontrib><creatorcontrib>Hidalgo García, Irene</creatorcontrib><creatorcontrib>Peleteiro Pensado, Ana</creatorcontrib><creatorcontrib>Pérez-Caballero Martínez, Ramón</creatorcontrib><creatorcontrib>Pardo Prado, Carlos A.</creatorcontrib><creatorcontrib>Rodríguez Ogando, Alejandro</creatorcontrib><creatorcontrib>López Blazquez, María</creatorcontrib><creatorcontrib>López-Herce Cid, Jesús</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiovascular translational research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>González Cortés, Rafael</au><au>Urbano Villaescusa, Javier</au><au>Solana García, María J.</au><au>López González, Jorge</au><au>Fernández Lafever, Sarah N.</au><au>Ramírez Gómez, Blanca</au><au>Fuentes Moran, José R.</au><au>Hidalgo García, Irene</au><au>Peleteiro Pensado, Ana</au><au>Pérez-Caballero Martínez, Ramón</au><au>Pardo Prado, Carlos A.</au><au>Rodríguez Ogando, Alejandro</au><au>López Blazquez, María</au><au>López-Herce Cid, Jesús</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microcirculatory Changes in Pediatric Patients During Congenital Heart Defect Corrective Surgery</atitle><jtitle>Journal of cardiovascular translational research</jtitle><stitle>J. of Cardiovasc. Trans. Res</stitle><addtitle>J Cardiovasc Transl Res</addtitle><date>2021-12-01</date><risdate>2021</risdate><volume>14</volume><issue>6</issue><spage>1173</spage><epage>1185</epage><pages>1173-1185</pages><issn>1937-5387</issn><eissn>1937-5395</eissn><abstract>A prospective, observational single-center study was carried out. Pediatric patients undergoing congenital heart defect surgery were evaluated before, during, and after surgery. At each time point, sublingual microcirculation and clinical parameters were assessed, along with analytical variables. Twenty-four patients were included. All microcirculatory parameters worsened during cardiopulmonary bypass and returned to baseline values after surgery (
p
≤ 0.001). In the intraoperative evaluation, body temperature correlated with perfused small vessel density (
p
= 0.014), proportion of perfused small vessels (
p
< 0.001), small vessel microvascular flow index (
p
= 0.003), and small vessel heterogeneity index (
p
< 0.002). Patients with cyanotic disease exhibited higher small vessel density (
p
< 0.008) and higher density of perfused small vessels (
p
< 0.022) at baseline, and a lower microvascular flow index (
p
= 0.022) and higher heterogeneity (
p
= 0.026) in the intraoperative phase. Children with congenital heart disease exhibited decreased vascular density and microvascular blood flow and increased heterogeneity during cardiopulmonary bypass. All these parameters returned to baseline values after surgery.
Graphical abstract</abstract><cop>New York</cop><pub>Springer US</pub><pmid>33948868</pmid><doi>10.1007/s12265-021-10132-w</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-3259-7898</orcidid></addata></record> |
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| subjects | Adolescent Biomedical Engineering and Bioengineering Biomedicine Blood Flow Velocity Cardiology Cardiopulmonary Bypass Child Child, Preschool Female Heart Defects, Congenital - surgery Human Genetics Humans Infant Intraoperative Period Male Medicine Medicine & Public Health Microcirculation Original Article Prospective Studies |
| title | Microcirculatory Changes in Pediatric Patients During Congenital Heart Defect Corrective Surgery |
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