Lgr4 promotes aerobic glycolysis and differentiation in osteoblasts via the canonical Wnt/β‐catenin pathway

ABSTRACT Lgr4, a G‐protein‐coupled receptor, is associated with various physiological and pathological processes including oncogenesis, energy metabolism, and bone remodeling. However, whether Lgr4 is involved in osteoblasts' metabolism is not clear. Here we uncover that in preosteoblast cell l...

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Veröffentlicht in:	Journal of bone and mineral research 2021-08, Vol.36 (8), p.1605-1620
Hauptverfasser:	Yang, Yu‐ying, Zhou, Yan‐man, Xu, Jing‐zun, Sun, Li‐hao, Tao, Bei, Wang, Wei‐qing, Wang, Ji‐qiu, Zhao, Hong‐yan, Liu, Jian‐min
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta Catenin - metabolism Bone growth Bone mass BONE REMODELING Catenin Cell Differentiation Energy metabolism GLYCOLYSIS Lactic acid Lgr4 Metabolism Mice Osteoblastogenesis OSTEOBLASTS Osteoblasts - metabolism Osteogenesis OSTEOPOROSIS Pyruvic acid Receptors, G-Protein-Coupled - genetics Tumorigenesis Wnt protein Wnt Signaling Pathway
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