Cutting Edge: TCR-β Selection Is Required at the CD4 + CD8 + Stage of Human T Cell Development

T cell development is predicated on the successful rearrangement of the TCR gene loci, which encode for Ag-specific receptors. Recombination-activating gene (RAG) 2 is required for TCR gene rearrangements, which occur during specific stages of T cell development. In this study, we differentiated hum...

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Veröffentlicht in:	The Journal of immunology (1950) 2021-05, Vol.206 (10), p.2271-2276
Hauptverfasser:	Chen, Edward L Y, Brauer, Patrick M, Martinez, Elisa C, Huang, Xiaotian, Yu, Ning, Anderson, Michele K, Li, Yang, Zúñiga-Pflücker, Juan Carlos
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD4 Antigens - metabolism CD8 Antigens - metabolism Cell Differentiation - genetics Cell Line, Tumor DNA-Binding Proteins - deficiency DNA-Binding Proteins - genetics Gene Knockout Techniques Gene Rearrangement, beta-Chain T-Cell Antigen Receptor - genetics Hematopoiesis - genetics Human Embryonic Stem Cells - cytology Humans Lymphocyte Activation - genetics Mice Mice, Inbred NOD Mice, SCID Nuclear Proteins - deficiency Nuclear Proteins - genetics Receptors, Antigen, T-Cell, alpha-beta - genetics Receptors, Antigen, T-Cell, alpha-beta - metabolism T-Lymphocytes - immunology Transduction, Genetic
Online-Zugang:	Volltext
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