Patient-Specific Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells as a Model to Study Autosomal Recessive Hypercholesterolemia

Autosomal recessive hypercholesterolemia (ARH) is a rare monogenic disorder caused by pathogenic variants in the low-density lipoprotein receptor (LDLR) adaptor protein 1 ( LDLRAP1 ) gene, encoding for the LDLRAP1 protein, which impairs internalization of hepatic LDLR. There are variable responses o...

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Veröffentlicht in:	Stem cells and development 2021-07, Vol.30 (14), p.714-724
Hauptverfasser:	Nikasa, Parisa, Tricot, Tine, Mahdieh, Nejat, Baharvand, Hossein, Totonchi, Mehdi, Hejazi, Mohammad Saeid, Verfaillie, Catherine M
Format:	Artikel
Sprache:	eng
Schlagworte:	Original Research Reports
Online-Zugang:	Volltext
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