High incidence of NMDAR encephalitis among Austronesians: A population-based study in Sabah, Malaysia
NMDAR encephalitis may be more common among non-Caucasians. A population-based study was conducted to estimate its incidence in Sabah, Malaysia, where the population consists predominantly of Austronesians (84%), and with a Chinese minority. Registries of NMDAR encephalitis at neurology referral cen...
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| Veröffentlicht in: | Journal of neuroimmunology 2021-07, Vol.356, p.577584-577584, Article 577584 |
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| creator | Wong, Chee Keong Hor, Jyh Yung Loo, Yin Pin Heng, Hock Sin Lee, Shirley Perianen, Presaad Pillai Ong, Sheila Ai Mei Majawit, Elyssa Milus Chang, Alison Yen Pin Chia, Yuen Kang Leite, M. Isabel |
| description | NMDAR encephalitis may be more common among non-Caucasians. A population-based study was conducted to estimate its incidence in Sabah, Malaysia, where the population consists predominantly of Austronesians (84%), and with a Chinese minority. Registries of NMDAR encephalitis at neurology referral centers were reviewed for case ascertainment. The annual incidence was 2.29/million (Austronesians: 2.56/million, Chinese: 1.31/million). Among pediatric population, the incidence was: Austronesians: 3.63/million, Chinese: 2.59/million. Our study demonstrated a higher incidence of NMDAR encephalitis among Austronesians than the predominantly Caucasian populations in Europe (0.5–0.9/million; pediatric: 0.7–1.5/million). Racial and genetic factors may contribute to risks of developing NMDAR encephalitis.
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•NMDAR encephalitis was observed to be more common among non-Caucasians.•High annual incidence (2.56/million) among Austronesians in Sabah, Malaysia.•In Sabah Austronesian pediatric population, the annual incidence was 3.63/million.•This was higher than in European populations ( |
| doi_str_mv | 10.1016/j.jneuroim.2021.577584 |
| format | Article |
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•NMDAR encephalitis was observed to be more common among non-Caucasians.•High annual incidence (2.56/million) among Austronesians in Sabah, Malaysia.•In Sabah Austronesian pediatric population, the annual incidence was 3.63/million.•This was higher than in European populations (<1/million; pediatric: 0.7–1.5/million).•Racial and genetic factors may contribute to risks of developing NMDAR encephalitis.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/j.jneuroim.2021.577584</identifier><identifier>PMID: 33933821</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Asia ; Epidemiology ; Incidence ; NMDA receptor encephalitis ; Population study</subject><ispartof>Journal of neuroimmunology, 2021-07, Vol.356, p.577584-577584, Article 577584</ispartof><rights>2021 Elsevier B.V.</rights><rights>Copyright © 2021 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-d2842bd668c0f93606c6070831612e08ea40bbdb17cba7c76ece368d900648fa3</citedby><cites>FETCH-LOGICAL-c368t-d2842bd668c0f93606c6070831612e08ea40bbdb17cba7c76ece368d900648fa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0165572821001119$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33933821$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wong, Chee Keong</creatorcontrib><creatorcontrib>Hor, Jyh Yung</creatorcontrib><creatorcontrib>Loo, Yin Pin</creatorcontrib><creatorcontrib>Heng, Hock Sin</creatorcontrib><creatorcontrib>Lee, Shirley</creatorcontrib><creatorcontrib>Perianen, Presaad Pillai</creatorcontrib><creatorcontrib>Ong, Sheila Ai Mei</creatorcontrib><creatorcontrib>Majawit, Elyssa Milus</creatorcontrib><creatorcontrib>Chang, Alison Yen Pin</creatorcontrib><creatorcontrib>Chia, Yuen Kang</creatorcontrib><creatorcontrib>Leite, M. Isabel</creatorcontrib><title>High incidence of NMDAR encephalitis among Austronesians: A population-based study in Sabah, Malaysia</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>NMDAR encephalitis may be more common among non-Caucasians. A population-based study was conducted to estimate its incidence in Sabah, Malaysia, where the population consists predominantly of Austronesians (84%), and with a Chinese minority. Registries of NMDAR encephalitis at neurology referral centers were reviewed for case ascertainment. The annual incidence was 2.29/million (Austronesians: 2.56/million, Chinese: 1.31/million). Among pediatric population, the incidence was: Austronesians: 3.63/million, Chinese: 2.59/million. Our study demonstrated a higher incidence of NMDAR encephalitis among Austronesians than the predominantly Caucasian populations in Europe (0.5–0.9/million; pediatric: 0.7–1.5/million). Racial and genetic factors may contribute to risks of developing NMDAR encephalitis.
[Display omitted]
•NMDAR encephalitis was observed to be more common among non-Caucasians.•High annual incidence (2.56/million) among Austronesians in Sabah, Malaysia.•In Sabah Austronesian pediatric population, the annual incidence was 3.63/million.•This was higher than in European populations (<1/million; pediatric: 0.7–1.5/million).•Racial and genetic factors may contribute to risks of developing NMDAR encephalitis.</description><subject>Asia</subject><subject>Epidemiology</subject><subject>Incidence</subject><subject>NMDA receptor encephalitis</subject><subject>Population study</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqFkEtP3DAURq2qVZlS_gLysotm6kdiO10xAloqzYBUYG059g3jURIHO0Gaf1-PBrpldXWl893HQeickiUlVPzYLXcDzDH4fskIo8tKykqVH9CCKskKVTL6ES0yWBWVZOoEfUlpRwiteFl_Riec15wrRhcIbvzTFvvBegeDBRxafLu5Wv3Fh27cms5PPmHTh-EJr-Y0xTBA8mZIP_EKj2GcOzP5MBSNSeBwmma3z9PwvWnM9jvemM7sM_4VfWpNl-DstZ6ix1_XD5c3xfru95_L1bqwXKipcCwf3jghlCVtzQURVhBJFKeCMiAKTEmaxjVU2sZIKwVYyEFXEyJK1Rp-ir4d544xPM-QJt37ZKHrzABhTppVjJa1pFWdUXFEbQwpRWj1GH1v4l5Tog-K9U6_KdYHxfqoOAfPX3fMTQ_uf-zNaQYujgDkT188RJ2sP-h0PoKdtAv-vR3_AABbkGs</recordid><startdate>20210715</startdate><enddate>20210715</enddate><creator>Wong, Chee Keong</creator><creator>Hor, Jyh Yung</creator><creator>Loo, Yin Pin</creator><creator>Heng, Hock Sin</creator><creator>Lee, Shirley</creator><creator>Perianen, Presaad Pillai</creator><creator>Ong, Sheila Ai Mei</creator><creator>Majawit, Elyssa Milus</creator><creator>Chang, Alison Yen Pin</creator><creator>Chia, Yuen Kang</creator><creator>Leite, M. Isabel</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20210715</creationdate><title>High incidence of NMDAR encephalitis among Austronesians: A population-based study in Sabah, Malaysia</title><author>Wong, Chee Keong ; Hor, Jyh Yung ; Loo, Yin Pin ; Heng, Hock Sin ; Lee, Shirley ; Perianen, Presaad Pillai ; Ong, Sheila Ai Mei ; Majawit, Elyssa Milus ; Chang, Alison Yen Pin ; Chia, Yuen Kang ; Leite, M. Isabel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-d2842bd668c0f93606c6070831612e08ea40bbdb17cba7c76ece368d900648fa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Asia</topic><topic>Epidemiology</topic><topic>Incidence</topic><topic>NMDA receptor encephalitis</topic><topic>Population study</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wong, Chee Keong</creatorcontrib><creatorcontrib>Hor, Jyh Yung</creatorcontrib><creatorcontrib>Loo, Yin Pin</creatorcontrib><creatorcontrib>Heng, Hock Sin</creatorcontrib><creatorcontrib>Lee, Shirley</creatorcontrib><creatorcontrib>Perianen, Presaad Pillai</creatorcontrib><creatorcontrib>Ong, Sheila Ai Mei</creatorcontrib><creatorcontrib>Majawit, Elyssa Milus</creatorcontrib><creatorcontrib>Chang, Alison Yen Pin</creatorcontrib><creatorcontrib>Chia, Yuen Kang</creatorcontrib><creatorcontrib>Leite, M. Isabel</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wong, Chee Keong</au><au>Hor, Jyh Yung</au><au>Loo, Yin Pin</au><au>Heng, Hock Sin</au><au>Lee, Shirley</au><au>Perianen, Presaad Pillai</au><au>Ong, Sheila Ai Mei</au><au>Majawit, Elyssa Milus</au><au>Chang, Alison Yen Pin</au><au>Chia, Yuen Kang</au><au>Leite, M. Isabel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High incidence of NMDAR encephalitis among Austronesians: A population-based study in Sabah, Malaysia</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>2021-07-15</date><risdate>2021</risdate><volume>356</volume><spage>577584</spage><epage>577584</epage><pages>577584-577584</pages><artnum>577584</artnum><issn>0165-5728</issn><eissn>1872-8421</eissn><abstract>NMDAR encephalitis may be more common among non-Caucasians. A population-based study was conducted to estimate its incidence in Sabah, Malaysia, where the population consists predominantly of Austronesians (84%), and with a Chinese minority. Registries of NMDAR encephalitis at neurology referral centers were reviewed for case ascertainment. The annual incidence was 2.29/million (Austronesians: 2.56/million, Chinese: 1.31/million). Among pediatric population, the incidence was: Austronesians: 3.63/million, Chinese: 2.59/million. Our study demonstrated a higher incidence of NMDAR encephalitis among Austronesians than the predominantly Caucasian populations in Europe (0.5–0.9/million; pediatric: 0.7–1.5/million). Racial and genetic factors may contribute to risks of developing NMDAR encephalitis.
[Display omitted]
•NMDAR encephalitis was observed to be more common among non-Caucasians.•High annual incidence (2.56/million) among Austronesians in Sabah, Malaysia.•In Sabah Austronesian pediatric population, the annual incidence was 3.63/million.•This was higher than in European populations (<1/million; pediatric: 0.7–1.5/million).•Racial and genetic factors may contribute to risks of developing NMDAR encephalitis.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>33933821</pmid><doi>10.1016/j.jneuroim.2021.577584</doi><tpages>1</tpages></addata></record> |
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| subjects | Asia Epidemiology Incidence NMDA receptor encephalitis Population study |
| title | High incidence of NMDAR encephalitis among Austronesians: A population-based study in Sabah, Malaysia |
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