Impact of a CD36 inhibitor on Porphyromonas gingivalis mediated atherosclerosis

•CD36 inhibitor, AP5055 abrogates atherosclerotic lesion burden associated with periodontal disease.•In vitro analysis showed that AP5055 inhibited the transcriptional activity of NF-κB.•AP5055 decreased levels of cholesterol in plasma.•AP5055 has a role in the reduction of pro-inflammatory cytokine...

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Veröffentlicht in:	Archives of oral biology 2021-06, Vol.126, p.105129-105129, Article 105129
Hauptverfasser:	Rekhi, Umar Rauf, Catunda, Raisa Queiroz, Alexiou, Maria, Sharma, Monika, Fong, Aaron, Febbraio, Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	AP5055 Atherosclerosis CD36 inhibitor Dentistry Dentistry, Oral Surgery & Medicine Life Sciences & Biomedicine Periodontal disease Porphyromonas gingivalis Science & Technology
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