Mitophagy reporter mouse analysis reveals increased mitophagy activity in disuse‐induced muscle atrophy

Muscle disuse induces atrophy through increased reactive oxygen species (ROS) released from damaged mitochondria. Mitophagy, the autophagic degradation of mitochondria, is associated with increased ROS production. However, the mitophagy activity status during disuse‐induced muscle atrophy has been a...

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Veröffentlicht in:	Journal of cellular physiology 2021-11, Vol.236 (11), p.7612-7624
Hauptverfasser:	Yamashita, Shun‐Ichi, Kyuuma, Masanao, Inoue, Keiichi, Hata, Yuki, Kawada, Ryu, Yamabi, Masaki, Fujii, Yasuyuki, Sakagami, Junko, Fukuda, Tomoyuki, Furukawa, Kentaro, Tsukamoto, Satoshi, Kanki, Tomotake
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Atrophy BNIP3 protein Disease Models, Animal disuse‐induced muscle atrophy Gene expression Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism hindlimb immobilization Hindlimb Suspension Immobilization Luminescent Proteins - genetics Luminescent Proteins - metabolism Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Inbred C57BL Mice, Transgenic Mitochondria Mitochondria, Heart - genetics Mitochondria, Heart - metabolism Mitochondria, Heart - pathology Mitochondria, Muscle - genetics Mitochondria, Muscle - metabolism Mitochondria, Muscle - pathology Mitophagy Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Muscles Muscular Atrophy - genetics Muscular Atrophy - metabolism Muscular Atrophy - pathology Myocardium - metabolism Myocardium - pathology Reactive oxygen species Reactive Oxygen Species - metabolism Red Fluorescent Protein ROS Signal Transduction Skeletal muscle Starvation Therapeutic targets Time Factors
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