CaMKII activation persistently segregates postsynaptic proteins via liquid phase separation

Transient information input to the brain leads to persistent changes in synaptic circuits, contributing to the formation of memory engrams. Pre- and postsynaptic structures undergo coordinated functional and structural changes during this process, but how such changes are achieved by their component...

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Veröffentlicht in:	Nature neuroscience 2021-06, Vol.24 (6), p.777-785
Hauptverfasser:	Hosokawa, Tomohisa, Liu, Pin-Wu, Cai, Qixu, Ferreira, Joana S., Levet, Florian, Butler, Corey, Sibarita, Jean-Baptiste, Choquet, Daniel, Groc, Laurent, Hosy, Eric, Zhang, Mingjie, Hayashi, Yasunori
Format:	Artikel
Sprache:	eng
Schlagworte:	14/19 14/35 38/70 631/378/2591 631/378/340 82/1 82/29 82/80 82/83 Amino Acid Sequence Animal Genetics and Genomics Animals Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Brain research Ca2+/calmodulin-dependent protein kinase II Calcium channels Calcium ions Calcium signalling Calcium-Calmodulin-Dependent Protein Kinase Type 2 - analysis Calcium-Calmodulin-Dependent Protein Kinase Type 2 - genetics Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism Cellular signal transduction Chemical properties Enzyme Activation - physiology Female Glutamic acid receptors Glutamic acid receptors (ionotropic) Kinases Liquid phases Liquid-Liquid Extraction - methods Male Membrane Proteins - analysis Membrane Proteins - genetics Membrane Proteins - metabolism Memory Mice Microscopy N-Methyl-D-aspartic acid receptors Neural transmission Neurobiology Neurosciences Phase separation Phase transformations (Statistical physics) Physiological aspects Plasticity Protein kinases Proteins Rats Rats, Sprague-Dawley Receptors Receptors, AMPA - analysis Receptors, AMPA - genetics Receptors, AMPA - metabolism Receptors, N-Methyl-D-Aspartate - analysis Receptors, N-Methyl-D-Aspartate - genetics Receptors, N-Methyl-D-Aspartate - metabolism Science Selective binding Structure-function relationships Synaptic plasticity Synaptic transmission α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors
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