Arginine and lysine methylation of MRPS23 promotes breast cancer metastasis through regulating OXPHOS

Mitochondrial oxidative phosphorylation (OXPHOS) is a vital regulator of tumor metastasis. However, the mechanisms governing OXPHOS to facilitate tumor metastasis remain unclear. In this study, we discovered that arginine 21(R21) and lysine 108 (K108) of mitochondrial ribosomal protein S23 (MRPS23)...

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Veröffentlicht in:	Oncogene 2021-05, Vol.40 (20), p.3548-3563
Hauptverfasser:	Liu, Lingxia, Zhang, Xiliu, Ding, Huayi, Liu, Xin, Cao, Donghui, Liu, Yingqi, Liu, Jiwei, Lin, Cong, Zhang, Na, Wang, Guannan, Hou, Jingyao, Huang, Baiqu, Zhang, Yu, Lu, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	101/58 13 13/1 13/2 13/31 13/51 13/89 38 38/77 38/90 631/67/1347 631/67/2327 64/60 82/83 Apoptosis Arginine Arginine - chemistry Breast cancer Breast carcinoma Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Cell Biology Cell Line, Tumor Cell Proliferation - physiology Cell survival Development and progression Female Genetic aspects Genetic regulation Health aspects Human Genetics Humans Internal Medicine Lysine Lysine - chemistry Medicine Medicine & Public Health Metastases Metastasis Methylation Mitochondria Mitochondria - metabolism Mitochondria - pathology Neoplasm Metastasis Oncology Oncology, Experimental Organoids Oxidative Phosphorylation Phosphorylation Protein arginine methyltransferase Protein Methyltransferases - genetics Protein Methyltransferases - metabolism Protein Processing, Post-Translational Protein-Arginine N-Methyltransferases - genetics Protein-Arginine N-Methyltransferases - metabolism Proteins Ribosomal proteins Ubiquitin
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