Juglone regulates gut microbiota and Th17/Treg balance in DSS-induced ulcerative colitis

•Juglone was first confirmed to protect mice against DSS-induced UC.•Juglone affected the composition of gut microbiota in UC mice.•Juglone regulated the levels of IL-6, STAT3, RORγt and FOXP3, restored Th17/Treg balance.•Juglone modulated the protein expressions of pro- and anti-inflammatory factor...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International immunopharmacology 2021-08, Vol.97, p.107683-107683, Article 107683
Hauptverfasser:	Hua, Yongzhi, Liu, Ruiqi, Lu, Min, Guan, Xueneng, Zhuang, Suyang, Tian, Yaozhou, Zhang, Zhenhai, Cui, Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Abundance Animals Anticancer properties Colitis, Ulcerative - chemically induced Colitis, Ulcerative - drug therapy Colitis, Ulcerative - immunology Colitis, Ulcerative - microbiology Colon - drug effects Colon - immunology Colon - microbiology Dextran Sulfate - administration & dosage Dextran Sulfate - toxicity Disease Models, Animal Drug Evaluation, Preclinical Foxp3 protein Gastrointestinal Microbiome - drug effects Gastrointestinal Microbiome - immunology Gut microbiota Helper cells Homeostasis Humans IL-1β Inflammatory bowel disease Interleukin 10 Interleukin 6 Intestinal microflora Intestinal Mucosa - drug effects Intestinal Mucosa - immunology Intestinal Mucosa - microbiology Juglans mandshurica Juglone Lymphocytes T Male Mice Microbiota Microorganisms Naphthoquinones - pharmacology Naphthoquinones - therapeutic use Proteins Stat3 protein T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology Th17 Cells - drug effects Th17 Cells - immunology Th17/Treg Tumor necrosis factor-α Ulcerative colitis Walnuts
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!