Concurrent zinc and vitamin B6 deficiencies in acutely exacerbated inflammatory bowel disease: Case reports
Background Limited evidence is available to describe the prevalence, causes, and consequences of zinc and vitamin B6 deficiencies in those with acutely exacerbated inflammatory bowel disease (IBD). Zinc is important for immune function and wound healing, and B6 is needed for metabolic and neurologic...
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Veröffentlicht in: | Nutrition in clinical practice 2022-02, Vol.37 (1), p.203-208 |
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creator | Moon, Nabeel Figgins, Bradley Altshuler, Ellery Pham, Angela Kamel, Amir Y. |
description | Background
Limited evidence is available to describe the prevalence, causes, and consequences of zinc and vitamin B6 deficiencies in those with acutely exacerbated inflammatory bowel disease (IBD). Zinc is important for immune function and wound healing, and B6 is needed for metabolic and neurological function. Patients with IBD are at risk of micronutrient deficiencies, particularly during flares.
Presentations
The cases of 2 patients with IBD exacerbations were reviewed in which deficiencies of both zinc and vitamin B6 were identified.
Conclusions
These cases highlight the need for increased screening for zinc and pyridoxine deficiencies in IBD population, especially during disease exacerbation. Therefore, we recommend a comprehensive nutrition workup with physical exam, diet history, and a complete micronutrient panel while ruling out contributing factors. If patients are susceptible to deficiencies during flares, prophylactic oral zinc and pyridoxine supplementation may be considered, with close monitoring for subsequent iron and copper deficiencies. |
doi_str_mv | 10.1002/ncp.10665 |
format | Article |
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Limited evidence is available to describe the prevalence, causes, and consequences of zinc and vitamin B6 deficiencies in those with acutely exacerbated inflammatory bowel disease (IBD). Zinc is important for immune function and wound healing, and B6 is needed for metabolic and neurological function. Patients with IBD are at risk of micronutrient deficiencies, particularly during flares.
Presentations
The cases of 2 patients with IBD exacerbations were reviewed in which deficiencies of both zinc and vitamin B6 were identified.
Conclusions
These cases highlight the need for increased screening for zinc and pyridoxine deficiencies in IBD population, especially during disease exacerbation. Therefore, we recommend a comprehensive nutrition workup with physical exam, diet history, and a complete micronutrient panel while ruling out contributing factors. If patients are susceptible to deficiencies during flares, prophylactic oral zinc and pyridoxine supplementation may be considered, with close monitoring for subsequent iron and copper deficiencies.</description><identifier>ISSN: 0884-5336</identifier><identifier>EISSN: 1941-2452</identifier><identifier>DOI: 10.1002/ncp.10665</identifier><language>eng</language><subject>Crohn's disease ; inflammatory bowel disease ; nutrient deficiency ; pyridoxine ; vitamin B6 deficiency ; zinc</subject><ispartof>Nutrition in clinical practice, 2022-02, Vol.37 (1), p.203-208</ispartof><rights>2021 American Society for Parenteral and Enteral Nutrition</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0003-1811-317X ; 0000-0002-7295-1185</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fncp.10665$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fncp.10665$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids></links><search><creatorcontrib>Moon, Nabeel</creatorcontrib><creatorcontrib>Figgins, Bradley</creatorcontrib><creatorcontrib>Altshuler, Ellery</creatorcontrib><creatorcontrib>Pham, Angela</creatorcontrib><creatorcontrib>Kamel, Amir Y.</creatorcontrib><title>Concurrent zinc and vitamin B6 deficiencies in acutely exacerbated inflammatory bowel disease: Case reports</title><title>Nutrition in clinical practice</title><description>Background
Limited evidence is available to describe the prevalence, causes, and consequences of zinc and vitamin B6 deficiencies in those with acutely exacerbated inflammatory bowel disease (IBD). Zinc is important for immune function and wound healing, and B6 is needed for metabolic and neurological function. Patients with IBD are at risk of micronutrient deficiencies, particularly during flares.
Presentations
The cases of 2 patients with IBD exacerbations were reviewed in which deficiencies of both zinc and vitamin B6 were identified.
Conclusions
These cases highlight the need for increased screening for zinc and pyridoxine deficiencies in IBD population, especially during disease exacerbation. Therefore, we recommend a comprehensive nutrition workup with physical exam, diet history, and a complete micronutrient panel while ruling out contributing factors. If patients are susceptible to deficiencies during flares, prophylactic oral zinc and pyridoxine supplementation may be considered, with close monitoring for subsequent iron and copper deficiencies.</description><subject>Crohn's disease</subject><subject>inflammatory bowel disease</subject><subject>nutrient deficiency</subject><subject>pyridoxine</subject><subject>vitamin B6 deficiency</subject><subject>zinc</subject><issn>0884-5336</issn><issn>1941-2452</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNotkLtOxDAURC0EEstCwR-4pAnrR-x46SDiJa2AAmrLca4lQ-IEO2EJX0_YpZg7o9HoFgehc0ouKSFsFWw_BynFAVrQdU4zlgt2iBZEqTwTnMtjdJLSOyFU8UIt0EfZBTvGCGHAPz5YbEKNv_xgWh_wjcQ1OG89hFkJz5Wx4wDNhOHbWIiVGaCea9eYtjVDFydcdVtocO0TmARXuJwvjtB3cUin6MiZJsHZvy_R293ta_mQbZ7vH8vrTdbTnIvMMekcV8aaiudcUWd5BaRW6xxMLSnQqoLCktrWTggu1pV0nEgiDXdFAdTwJbrY_-1j9zlCGnTrk4WmMQG6MWkmGFEFo4zP09V-uvUNTLqPvjVx0pToP5p6pql3NPVT-bIL_Bf9Zmv8</recordid><startdate>202202</startdate><enddate>202202</enddate><creator>Moon, Nabeel</creator><creator>Figgins, Bradley</creator><creator>Altshuler, Ellery</creator><creator>Pham, Angela</creator><creator>Kamel, Amir Y.</creator><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1811-317X</orcidid><orcidid>https://orcid.org/0000-0002-7295-1185</orcidid></search><sort><creationdate>202202</creationdate><title>Concurrent zinc and vitamin B6 deficiencies in acutely exacerbated inflammatory bowel disease: Case reports</title><author>Moon, Nabeel ; Figgins, Bradley ; Altshuler, Ellery ; Pham, Angela ; Kamel, Amir Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p1435-f26ff38acab34381fc3be0d894ead61e1bbe7c0dcdf55359b6f30606a3f77e1a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Crohn's disease</topic><topic>inflammatory bowel disease</topic><topic>nutrient deficiency</topic><topic>pyridoxine</topic><topic>vitamin B6 deficiency</topic><topic>zinc</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moon, Nabeel</creatorcontrib><creatorcontrib>Figgins, Bradley</creatorcontrib><creatorcontrib>Altshuler, Ellery</creatorcontrib><creatorcontrib>Pham, Angela</creatorcontrib><creatorcontrib>Kamel, Amir Y.</creatorcontrib><collection>MEDLINE - Academic</collection><jtitle>Nutrition in clinical practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moon, Nabeel</au><au>Figgins, Bradley</au><au>Altshuler, Ellery</au><au>Pham, Angela</au><au>Kamel, Amir Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Concurrent zinc and vitamin B6 deficiencies in acutely exacerbated inflammatory bowel disease: Case reports</atitle><jtitle>Nutrition in clinical practice</jtitle><date>2022-02</date><risdate>2022</risdate><volume>37</volume><issue>1</issue><spage>203</spage><epage>208</epage><pages>203-208</pages><issn>0884-5336</issn><eissn>1941-2452</eissn><abstract>Background
Limited evidence is available to describe the prevalence, causes, and consequences of zinc and vitamin B6 deficiencies in those with acutely exacerbated inflammatory bowel disease (IBD). Zinc is important for immune function and wound healing, and B6 is needed for metabolic and neurological function. Patients with IBD are at risk of micronutrient deficiencies, particularly during flares.
Presentations
The cases of 2 patients with IBD exacerbations were reviewed in which deficiencies of both zinc and vitamin B6 were identified.
Conclusions
These cases highlight the need for increased screening for zinc and pyridoxine deficiencies in IBD population, especially during disease exacerbation. Therefore, we recommend a comprehensive nutrition workup with physical exam, diet history, and a complete micronutrient panel while ruling out contributing factors. If patients are susceptible to deficiencies during flares, prophylactic oral zinc and pyridoxine supplementation may be considered, with close monitoring for subsequent iron and copper deficiencies.</abstract><doi>10.1002/ncp.10665</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-1811-317X</orcidid><orcidid>https://orcid.org/0000-0002-7295-1185</orcidid></addata></record> |
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subjects | Crohn's disease inflammatory bowel disease nutrient deficiency pyridoxine vitamin B6 deficiency zinc |
title | Concurrent zinc and vitamin B6 deficiencies in acutely exacerbated inflammatory bowel disease: Case reports |
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