Characterization of the chemical profile and the effects of ethanolic extracts of Maytenus ilicifolia Mart. ex Reissek on glucose metabolism in normal hyperglycemic rats
Maytenus ilicifolia Mart. ex Reissek, Celastraceae, is popularly known as “espinheira-santa” and used to treat pathologies related to the stomach. However, in popular culture, this species has also been used to treat other disorders such as diabetes, but without scientific evidence, requiring more p...
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| Veröffentlicht in: | Journal of ethnopharmacology 2021-08, Vol.276, p.114173-114173, Article 114173 |
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| creator | Schindler, Monica Santin Zanatta Calisto, Jean Felipe Fossá Marins, Katiuska Regginato, Alissara Mezzomo, Hemilli Zanatta, Ana Paula Radunz, Andre Luiz Mariot, Márcio Paim Dal Magro, Jacir Zanatta, Leila |
| description | Maytenus ilicifolia Mart. ex Reissek, Celastraceae, is popularly known as “espinheira-santa” and used to treat pathologies related to the stomach. However, in popular culture, this species has also been used to treat other disorders such as diabetes, but without scientific evidence, requiring more phytochemical and pharmacological studies on the plant.
This work aims to investigate the anti-hyperglycemic potential of ethanolic extracts obtained from leaves from two different accessions of Maytenus ilicifolia (MIA and MIB) in normal hyperglycemic rats.
The animals were divided into different experimental groups: normal hyperglycemic (negative control); MIA (treatment of Maytenus ilicifolia extract from access 116); MIB (treatment with Maytenus ilicifolia extract from access 122; and glipizide (positive control). At 30 min after treatment, all animals received glucose overload orally. Blood collection occurred at different periods for the assessment of blood glucose (0, 60, 90 and 210 min after treatment) and at the end of the experiment blood was collected through cardiac puncture and the liver, muscle, pancreas and intestine were dissected for further analysis.
Chromatographic analysis identified oleic and palmitic acid as the most common constituents, and both extracts of Maytenus ilicifolia caused a reduction in blood glucose levels within 60 min after administration of glucose overload when compared to the normal hyperglycemic group. No significant changes were observed in hepatic and muscular glycogen levels, plasma insulin concentration and disaccharidases activity with none of the extracts in the model employed. However, hyperglycemic rats treated with the extracts showed a marked increase in triglyceride and HDL cholesterol levels.
Our data suggest that Maytenus ilicifolia extracts from different locations showed differences in chemical composition which did not reflect significant differences in the results of biological tests. In addition, it was possible to conclude that the treatment with Maytenus ilicifolia had a discreet anti-hyperglycemic effect; however, it was not possible to identify the responsible mechanism, being necessary, therefore, new studies using different technologies in order to determine the possible mechanisms of action of the extract.
[Display omitted] |
| doi_str_mv | 10.1016/j.jep.2021.114173 |
| format | Article |
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This work aims to investigate the anti-hyperglycemic potential of ethanolic extracts obtained from leaves from two different accessions of Maytenus ilicifolia (MIA and MIB) in normal hyperglycemic rats.
The animals were divided into different experimental groups: normal hyperglycemic (negative control); MIA (treatment of Maytenus ilicifolia extract from access 116); MIB (treatment with Maytenus ilicifolia extract from access 122; and glipizide (positive control). At 30 min after treatment, all animals received glucose overload orally. Blood collection occurred at different periods for the assessment of blood glucose (0, 60, 90 and 210 min after treatment) and at the end of the experiment blood was collected through cardiac puncture and the liver, muscle, pancreas and intestine were dissected for further analysis.
Chromatographic analysis identified oleic and palmitic acid as the most common constituents, and both extracts of Maytenus ilicifolia caused a reduction in blood glucose levels within 60 min after administration of glucose overload when compared to the normal hyperglycemic group. No significant changes were observed in hepatic and muscular glycogen levels, plasma insulin concentration and disaccharidases activity with none of the extracts in the model employed. However, hyperglycemic rats treated with the extracts showed a marked increase in triglyceride and HDL cholesterol levels.
Our data suggest that Maytenus ilicifolia extracts from different locations showed differences in chemical composition which did not reflect significant differences in the results of biological tests. In addition, it was possible to conclude that the treatment with Maytenus ilicifolia had a discreet anti-hyperglycemic effect; however, it was not possible to identify the responsible mechanism, being necessary, therefore, new studies using different technologies in order to determine the possible mechanisms of action of the extract.
[Display omitted]</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2021.114173</identifier><identifier>PMID: 33932519</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Alanine Transaminase - blood ; Animals ; Antidiabetic activity ; Antioxidant potential ; Blood Glucose - drug effects ; Disaccharides - metabolism ; Espinheira-santa ; Ethanol - chemistry ; Glipizide - pharmacology ; Glipizide - therapeutic use ; Glucose - metabolism ; Glycogen - metabolism ; HDL cholesterol ; Hyperglycemia - drug therapy ; Hyperglycemic rats ; Insulin - blood ; Lipids - blood ; Male ; Maytenus - chemistry ; Oxidative Stress - drug effects ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Plant Leaves - chemistry ; Rats ; Rats, Wistar ; Urea - blood</subject><ispartof>Journal of ethnopharmacology, 2021-08, Vol.276, p.114173-114173, Article 114173</ispartof><rights>2021 Elsevier B.V.</rights><rights>Copyright © 2021 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-5e63aa97bb646decf0156f84defb5bc315d75ec3984640a4003856e2c6271d1b3</citedby><cites>FETCH-LOGICAL-c353t-5e63aa97bb646decf0156f84defb5bc315d75ec3984640a4003856e2c6271d1b3</cites><orcidid>0000-0003-0935-4190</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jep.2021.114173$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33932519$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schindler, Monica Santin Zanatta</creatorcontrib><creatorcontrib>Calisto, Jean Felipe Fossá</creatorcontrib><creatorcontrib>Marins, Katiuska</creatorcontrib><creatorcontrib>Regginato, Alissara</creatorcontrib><creatorcontrib>Mezzomo, Hemilli</creatorcontrib><creatorcontrib>Zanatta, Ana Paula</creatorcontrib><creatorcontrib>Radunz, Andre Luiz</creatorcontrib><creatorcontrib>Mariot, Márcio Paim</creatorcontrib><creatorcontrib>Dal Magro, Jacir</creatorcontrib><creatorcontrib>Zanatta, Leila</creatorcontrib><title>Characterization of the chemical profile and the effects of ethanolic extracts of Maytenus ilicifolia Mart. ex Reissek on glucose metabolism in normal hyperglycemic rats</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>Maytenus ilicifolia Mart. ex Reissek, Celastraceae, is popularly known as “espinheira-santa” and used to treat pathologies related to the stomach. However, in popular culture, this species has also been used to treat other disorders such as diabetes, but without scientific evidence, requiring more phytochemical and pharmacological studies on the plant.
This work aims to investigate the anti-hyperglycemic potential of ethanolic extracts obtained from leaves from two different accessions of Maytenus ilicifolia (MIA and MIB) in normal hyperglycemic rats.
The animals were divided into different experimental groups: normal hyperglycemic (negative control); MIA (treatment of Maytenus ilicifolia extract from access 116); MIB (treatment with Maytenus ilicifolia extract from access 122; and glipizide (positive control). At 30 min after treatment, all animals received glucose overload orally. Blood collection occurred at different periods for the assessment of blood glucose (0, 60, 90 and 210 min after treatment) and at the end of the experiment blood was collected through cardiac puncture and the liver, muscle, pancreas and intestine were dissected for further analysis.
Chromatographic analysis identified oleic and palmitic acid as the most common constituents, and both extracts of Maytenus ilicifolia caused a reduction in blood glucose levels within 60 min after administration of glucose overload when compared to the normal hyperglycemic group. No significant changes were observed in hepatic and muscular glycogen levels, plasma insulin concentration and disaccharidases activity with none of the extracts in the model employed. However, hyperglycemic rats treated with the extracts showed a marked increase in triglyceride and HDL cholesterol levels.
Our data suggest that Maytenus ilicifolia extracts from different locations showed differences in chemical composition which did not reflect significant differences in the results of biological tests. In addition, it was possible to conclude that the treatment with Maytenus ilicifolia had a discreet anti-hyperglycemic effect; however, it was not possible to identify the responsible mechanism, being necessary, therefore, new studies using different technologies in order to determine the possible mechanisms of action of the extract.
[Display omitted]</description><subject>Alanine Transaminase - blood</subject><subject>Animals</subject><subject>Antidiabetic activity</subject><subject>Antioxidant potential</subject><subject>Blood Glucose - drug effects</subject><subject>Disaccharides - metabolism</subject><subject>Espinheira-santa</subject><subject>Ethanol - chemistry</subject><subject>Glipizide - pharmacology</subject><subject>Glipizide - therapeutic use</subject><subject>Glucose - metabolism</subject><subject>Glycogen - metabolism</subject><subject>HDL cholesterol</subject><subject>Hyperglycemia - drug therapy</subject><subject>Hyperglycemic rats</subject><subject>Insulin - blood</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Maytenus - chemistry</subject><subject>Oxidative Stress - drug effects</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Leaves - chemistry</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Urea - blood</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu1DAQhi0EokvhAbggH7kkeOI4zooTWhWKVFQJtWfLccaNlyRebKdieaO-JU63cORkaeabfzz_T8hbYCUwaD7syz0eyopVUALUIPkzsoFWVoUUkj8nG8ZlW7SyhjPyKsY9Y0xCzV6SM863vBKw3ZCH3aCDNgmD-62T8zP1lqYBqRlwckaP9BC8dSNSPfePDbQWTYorh2nQsx-dofgrrSqP1W_6mHBeInW542zu61wLqcwU_Y4uRvxB86K7cTE-Ip0w6S5TcaJuprMPU946HA8Y7sajWX9Bg07xNXlh9RjxzdN7Tm4_X9zsLour6y9fd5-uCsMFT4XAhmu9lV3X1E2PxjIQjW3rHm0nOsNB9FKg4du2bmqma8Z4KxqsTFNJ6KHj5-T9STcf_nPBmNTkosFx1DP6JapKVCx7nL3NKJxQE3yMAa06BDfpcFTA1JqQ2quckFoTUqeE8sy7J_mlm7D_N_E3kgx8PAGYj7x3GFQ0DmeDvQvZeNV79x_5P7hRpKs</recordid><startdate>20210810</startdate><enddate>20210810</enddate><creator>Schindler, Monica Santin Zanatta</creator><creator>Calisto, Jean Felipe Fossá</creator><creator>Marins, Katiuska</creator><creator>Regginato, Alissara</creator><creator>Mezzomo, Hemilli</creator><creator>Zanatta, Ana Paula</creator><creator>Radunz, Andre Luiz</creator><creator>Mariot, Márcio Paim</creator><creator>Dal Magro, Jacir</creator><creator>Zanatta, Leila</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0935-4190</orcidid></search><sort><creationdate>20210810</creationdate><title>Characterization of the chemical profile and the effects of ethanolic extracts of Maytenus ilicifolia Mart. ex Reissek on glucose metabolism in normal hyperglycemic rats</title><author>Schindler, Monica Santin Zanatta ; Calisto, Jean Felipe Fossá ; Marins, Katiuska ; Regginato, Alissara ; Mezzomo, Hemilli ; Zanatta, Ana Paula ; Radunz, Andre Luiz ; Mariot, Márcio Paim ; Dal Magro, Jacir ; Zanatta, Leila</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-5e63aa97bb646decf0156f84defb5bc315d75ec3984640a4003856e2c6271d1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Alanine Transaminase - blood</topic><topic>Animals</topic><topic>Antidiabetic activity</topic><topic>Antioxidant potential</topic><topic>Blood Glucose - drug effects</topic><topic>Disaccharides - metabolism</topic><topic>Espinheira-santa</topic><topic>Ethanol - chemistry</topic><topic>Glipizide - pharmacology</topic><topic>Glipizide - therapeutic use</topic><topic>Glucose - metabolism</topic><topic>Glycogen - metabolism</topic><topic>HDL cholesterol</topic><topic>Hyperglycemia - drug therapy</topic><topic>Hyperglycemic rats</topic><topic>Insulin - blood</topic><topic>Lipids - blood</topic><topic>Male</topic><topic>Maytenus - chemistry</topic><topic>Oxidative Stress - drug effects</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plant Leaves - chemistry</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Urea - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schindler, Monica Santin Zanatta</creatorcontrib><creatorcontrib>Calisto, Jean Felipe Fossá</creatorcontrib><creatorcontrib>Marins, Katiuska</creatorcontrib><creatorcontrib>Regginato, Alissara</creatorcontrib><creatorcontrib>Mezzomo, Hemilli</creatorcontrib><creatorcontrib>Zanatta, Ana Paula</creatorcontrib><creatorcontrib>Radunz, Andre Luiz</creatorcontrib><creatorcontrib>Mariot, Márcio Paim</creatorcontrib><creatorcontrib>Dal Magro, Jacir</creatorcontrib><creatorcontrib>Zanatta, Leila</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schindler, Monica Santin Zanatta</au><au>Calisto, Jean Felipe Fossá</au><au>Marins, Katiuska</au><au>Regginato, Alissara</au><au>Mezzomo, Hemilli</au><au>Zanatta, Ana Paula</au><au>Radunz, Andre Luiz</au><au>Mariot, Márcio Paim</au><au>Dal Magro, Jacir</au><au>Zanatta, Leila</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of the chemical profile and the effects of ethanolic extracts of Maytenus ilicifolia Mart. ex Reissek on glucose metabolism in normal hyperglycemic rats</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2021-08-10</date><risdate>2021</risdate><volume>276</volume><spage>114173</spage><epage>114173</epage><pages>114173-114173</pages><artnum>114173</artnum><issn>0378-8741</issn><eissn>1872-7573</eissn><abstract>Maytenus ilicifolia Mart. ex Reissek, Celastraceae, is popularly known as “espinheira-santa” and used to treat pathologies related to the stomach. However, in popular culture, this species has also been used to treat other disorders such as diabetes, but without scientific evidence, requiring more phytochemical and pharmacological studies on the plant.
This work aims to investigate the anti-hyperglycemic potential of ethanolic extracts obtained from leaves from two different accessions of Maytenus ilicifolia (MIA and MIB) in normal hyperglycemic rats.
The animals were divided into different experimental groups: normal hyperglycemic (negative control); MIA (treatment of Maytenus ilicifolia extract from access 116); MIB (treatment with Maytenus ilicifolia extract from access 122; and glipizide (positive control). At 30 min after treatment, all animals received glucose overload orally. Blood collection occurred at different periods for the assessment of blood glucose (0, 60, 90 and 210 min after treatment) and at the end of the experiment blood was collected through cardiac puncture and the liver, muscle, pancreas and intestine were dissected for further analysis.
Chromatographic analysis identified oleic and palmitic acid as the most common constituents, and both extracts of Maytenus ilicifolia caused a reduction in blood glucose levels within 60 min after administration of glucose overload when compared to the normal hyperglycemic group. No significant changes were observed in hepatic and muscular glycogen levels, plasma insulin concentration and disaccharidases activity with none of the extracts in the model employed. However, hyperglycemic rats treated with the extracts showed a marked increase in triglyceride and HDL cholesterol levels.
Our data suggest that Maytenus ilicifolia extracts from different locations showed differences in chemical composition which did not reflect significant differences in the results of biological tests. In addition, it was possible to conclude that the treatment with Maytenus ilicifolia had a discreet anti-hyperglycemic effect; however, it was not possible to identify the responsible mechanism, being necessary, therefore, new studies using different technologies in order to determine the possible mechanisms of action of the extract.
[Display omitted]</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>33932519</pmid><doi>10.1016/j.jep.2021.114173</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-0935-4190</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-8741 |
| ispartof | Journal of ethnopharmacology, 2021-08, Vol.276, p.114173-114173, Article 114173 |
| issn | 0378-8741 1872-7573 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Alanine Transaminase - blood Animals Antidiabetic activity Antioxidant potential Blood Glucose - drug effects Disaccharides - metabolism Espinheira-santa Ethanol - chemistry Glipizide - pharmacology Glipizide - therapeutic use Glucose - metabolism Glycogen - metabolism HDL cholesterol Hyperglycemia - drug therapy Hyperglycemic rats Insulin - blood Lipids - blood Male Maytenus - chemistry Oxidative Stress - drug effects Plant Extracts - chemistry Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Leaves - chemistry Rats Rats, Wistar Urea - blood |
| title | Characterization of the chemical profile and the effects of ethanolic extracts of Maytenus ilicifolia Mart. ex Reissek on glucose metabolism in normal hyperglycemic rats |
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