Utilizing neutron generators in boron neutron capture therapy

Neutron capture therapy (NCT) is a radiotherapeutic technique that is designed to utilize the neutron capture reaction and damage the tumor cells through the energy release from the reaction. Nuclear reactors are typically utilized in this therapy because of the high neutron fluence rate that can be achieved. There has been minimal work to evaluate the effectiveness of neutron generators in NCT. This work presents the preliminary simulation results of utilizing of a deuterium-deuterium generator in boron neutron capture therapy. MCNP 6.1 was used to model the detailed geometry of the neutron generator and the phantom. Neutron moderators and photon shielding were used to optimize the neutron fluence rate in the tumor and decrease the photon dose in the phantom respectively. The study showed that a good localization of the neutron dose can be achieved in the tumor area with a reduction of the photon dose in the surrounding areas. •A Deuteron-Deuteron neutron generator was investigated for neutron capture therapy.•A good localization of the neutron dose was achieved in the tumor area.•Neutron moderators and photon shielding were effectively used in the dose localization.