Prevalence of extracapsular extension in metastatic sentinel lymph nodes in breast cancer
Axillary lymph node involvement is recognized as a key prognostic factor for invasive breast cancer. Retrospective analyzes have shown that extracapsular extension (ECE) is correlated with negative prognostic factors in this neoplasia. to evaluate the measurement of ECE and its relationship with the...
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| Veröffentlicht in: | Surgical oncology 2021-09, Vol.38, p.101594-101594, Article 101594 |
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| creator | Layse de Menezes Dantas, Macerly Hugo da Silva Santos, Ythalo Alcântara da Silva, Pedro Henrique Medeiros de Azevedo, Fábio Petta, Tirzah Braz Sampaio Marinho Navarro, Diana Taissa |
| description | Axillary lymph node involvement is recognized as a key prognostic factor for invasive breast cancer. Retrospective analyzes have shown that extracapsular extension (ECE) is correlated with negative prognostic factors in this neoplasia.
to evaluate the measurement of ECE and its relationship with the number of affected non-sentinel lymph nodes, as well as to investigate the association between ECE with other clinical and pathological prognostic factors.
This is a cross-sectional observational study carried out from January 2015 to June 2019, at the Breast Surgical Oncology service of Liga Contra o Cancer (LIGA), in Natal, Brazil. A total of 150 patients were included in the study and were divided into three groups: absence of ECE, ECE less than or equal to 2 mm and ECE greater than 2 mm.
The mean age was 58 years for the group with ECE and 57 years for the group without ECE. Most of the patients were mixed race (66.7%), had no family history of breast cancer (64%) and underwent quadrantectomy (64.5%). Regarding the characteristics of the disease, most presented a histological report compatible with Invasive Carcinoma of the non-special type (IC NST) (87.5%), histological grade II (52.7%), negative Lymphovascular invasion (LVI) (52.7%), Tumor Size T1 ( 2 mm is associated with high axillary nodal load. |
| doi_str_mv | 10.1016/j.suronc.2021.101594 |
| format | Article |
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to evaluate the measurement of ECE and its relationship with the number of affected non-sentinel lymph nodes, as well as to investigate the association between ECE with other clinical and pathological prognostic factors.
This is a cross-sectional observational study carried out from January 2015 to June 2019, at the Breast Surgical Oncology service of Liga Contra o Cancer (LIGA), in Natal, Brazil. A total of 150 patients were included in the study and were divided into three groups: absence of ECE, ECE less than or equal to 2 mm and ECE greater than 2 mm.
The mean age was 58 years for the group with ECE and 57 years for the group without ECE. Most of the patients were mixed race (66.7%), had no family history of breast cancer (64%) and underwent quadrantectomy (64.5%). Regarding the characteristics of the disease, most presented a histological report compatible with Invasive Carcinoma of the non-special type (IC NST) (87.5%), histological grade II (52.7%), negative Lymphovascular invasion (LVI) (52.7%), Tumor Size T1 (<2.0 cm) (52%) and Luminal B molecular subtype (36.7%). Regarding sentinel lymph nodes: 103 patients (68.7%) had ECE and 1 positive sentinel lymph node was identified in most cases. There was a statistically significant association between the presence of ECE and of being mixed race (p = 0.03), between ECE and LVI (p = 0.05) and between ECE and a greater number of positive non-sentinel lymph nodes (p < 0.001).
Our study showed that ECE> 2 mm is associated with increased axillary nodal load compared to groups without ECE and ECE ≤ 2 mm in sentinel node biopsy in patients who met the Z0011 criteria.
•The majority of patients had ECE and 1 SLN+.•The presence of ECE was related to mixed race, LVI and greater number of SLN+.•Patient who met Z0011 criteria ECE> 2 mm is associated with high axillary nodal load.</description><identifier>ISSN: 0960-7404</identifier><identifier>EISSN: 1879-3320</identifier><identifier>DOI: 10.1016/j.suronc.2021.101594</identifier><identifier>PMID: 33930842</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biopsy ; Breast cancer ; Breast Neoplasms - pathology ; Breast Neoplasms - surgery ; Cancer therapies ; Cross-Sectional Studies ; Extracapsular extension ; Extranodal Extension - diagnosis ; Female ; Follow-Up Studies ; Genetics ; Humans ; Invasiveness ; Lymph Node Excision ; Lymph nodes ; Lymphatic Metastasis - diagnosis ; Lymphatic system ; Medical prognosis ; Metastases ; Metastasis ; Middle Aged ; Patients ; Prevalence ; Prognosis ; Race ; Sentinel Lymph Node - pathology ; Sentinel Lymph Node - surgery ; Sentinel Lymph Node Biopsy ; Sentinel lymph nodes ; Statistical analysis ; Tumors ; Womens health</subject><ispartof>Surgical oncology, 2021-09, Vol.38, p.101594-101594, Article 101594</ispartof><rights>2021 Elsevier Ltd</rights><rights>Copyright © 2021 Elsevier Ltd. All rights reserved.</rights><rights>2021. Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-fcb316c0607a5d31fd63857f1636511516ce4bd9cbcaf23ece80117a8a58440e3</citedby><cites>FETCH-LOGICAL-c390t-fcb316c0607a5d31fd63857f1636511516ce4bd9cbcaf23ece80117a8a58440e3</cites><orcidid>0000-0003-0890-9430</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0960740421000839$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33930842$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Layse de Menezes Dantas, Macerly</creatorcontrib><creatorcontrib>Hugo da Silva Santos, Ythalo</creatorcontrib><creatorcontrib>Alcântara da Silva, Pedro Henrique</creatorcontrib><creatorcontrib>Medeiros de Azevedo, Fábio</creatorcontrib><creatorcontrib>Petta, Tirzah Braz</creatorcontrib><creatorcontrib>Sampaio Marinho Navarro, Diana Taissa</creatorcontrib><title>Prevalence of extracapsular extension in metastatic sentinel lymph nodes in breast cancer</title><title>Surgical oncology</title><addtitle>Surg Oncol</addtitle><description>Axillary lymph node involvement is recognized as a key prognostic factor for invasive breast cancer. Retrospective analyzes have shown that extracapsular extension (ECE) is correlated with negative prognostic factors in this neoplasia.
to evaluate the measurement of ECE and its relationship with the number of affected non-sentinel lymph nodes, as well as to investigate the association between ECE with other clinical and pathological prognostic factors.
This is a cross-sectional observational study carried out from January 2015 to June 2019, at the Breast Surgical Oncology service of Liga Contra o Cancer (LIGA), in Natal, Brazil. A total of 150 patients were included in the study and were divided into three groups: absence of ECE, ECE less than or equal to 2 mm and ECE greater than 2 mm.
The mean age was 58 years for the group with ECE and 57 years for the group without ECE. Most of the patients were mixed race (66.7%), had no family history of breast cancer (64%) and underwent quadrantectomy (64.5%). Regarding the characteristics of the disease, most presented a histological report compatible with Invasive Carcinoma of the non-special type (IC NST) (87.5%), histological grade II (52.7%), negative Lymphovascular invasion (LVI) (52.7%), Tumor Size T1 (<2.0 cm) (52%) and Luminal B molecular subtype (36.7%). Regarding sentinel lymph nodes: 103 patients (68.7%) had ECE and 1 positive sentinel lymph node was identified in most cases. There was a statistically significant association between the presence of ECE and of being mixed race (p = 0.03), between ECE and LVI (p = 0.05) and between ECE and a greater number of positive non-sentinel lymph nodes (p < 0.001).
Our study showed that ECE> 2 mm is associated with increased axillary nodal load compared to groups without ECE and ECE ≤ 2 mm in sentinel node biopsy in patients who met the Z0011 criteria.
•The majority of patients had ECE and 1 SLN+.•The presence of ECE was related to mixed race, LVI and greater number of SLN+.•Patient who met Z0011 criteria ECE> 2 mm is associated with high axillary nodal load.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biopsy</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - surgery</subject><subject>Cancer therapies</subject><subject>Cross-Sectional Studies</subject><subject>Extracapsular extension</subject><subject>Extranodal Extension - diagnosis</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Genetics</subject><subject>Humans</subject><subject>Invasiveness</subject><subject>Lymph Node Excision</subject><subject>Lymph nodes</subject><subject>Lymphatic Metastasis - diagnosis</subject><subject>Lymphatic system</subject><subject>Medical prognosis</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Patients</subject><subject>Prevalence</subject><subject>Prognosis</subject><subject>Race</subject><subject>Sentinel Lymph Node - pathology</subject><subject>Sentinel Lymph Node - surgery</subject><subject>Sentinel Lymph Node Biopsy</subject><subject>Sentinel lymph nodes</subject><subject>Statistical analysis</subject><subject>Tumors</subject><subject>Womens health</subject><issn>0960-7404</issn><issn>1879-3320</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1q3DAUhUVJSCZp3qAUQzbZeHL1Y9neFMLQ_MBAskgXXQlZvqYytjSV7NC8fWWcdpFFVkLSd869fIR8obClQOV1v41z8M5sGTC6PBW1-EQ2tCrrnHMGR2QDtYS8FCBOyVmMPQDIktETcsp5zaESbEN-PgV80QM6g5nvMvwzBW30Ic6DDssNXbTeZdZlI046TnqyJovoJutwyIbX8fArc77FuCBNwIRkRqe28Jkcd3qIePF2npMft9-fd_f5_vHuYXezzw2vYco703AqDUgoddFy2rWSV0XZUcllQWmR_lA0bW0aozvG0WAFlJa60kUlBCA_J1dr7yH43zPGSY02GhwG7dDPUbGCQVUCA5nQy3do7-fg0naJkhUTTFKaKLFSJvgYA3bqEOyow6uioBb1qlererWoV6v6FPv6Vj43I7b_Q_9cJ-DbCmCy8WIxqGjsIr61Ac2kWm8_nvAXWZSW1g</recordid><startdate>202109</startdate><enddate>202109</enddate><creator>Layse de Menezes Dantas, Macerly</creator><creator>Hugo da Silva Santos, Ythalo</creator><creator>Alcântara da Silva, Pedro Henrique</creator><creator>Medeiros de Azevedo, Fábio</creator><creator>Petta, Tirzah Braz</creator><creator>Sampaio Marinho Navarro, Diana Taissa</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0890-9430</orcidid></search><sort><creationdate>202109</creationdate><title>Prevalence of extracapsular extension in metastatic sentinel lymph nodes in breast cancer</title><author>Layse de Menezes Dantas, Macerly ; 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Retrospective analyzes have shown that extracapsular extension (ECE) is correlated with negative prognostic factors in this neoplasia.
to evaluate the measurement of ECE and its relationship with the number of affected non-sentinel lymph nodes, as well as to investigate the association between ECE with other clinical and pathological prognostic factors.
This is a cross-sectional observational study carried out from January 2015 to June 2019, at the Breast Surgical Oncology service of Liga Contra o Cancer (LIGA), in Natal, Brazil. A total of 150 patients were included in the study and were divided into three groups: absence of ECE, ECE less than or equal to 2 mm and ECE greater than 2 mm.
The mean age was 58 years for the group with ECE and 57 years for the group without ECE. Most of the patients were mixed race (66.7%), had no family history of breast cancer (64%) and underwent quadrantectomy (64.5%). Regarding the characteristics of the disease, most presented a histological report compatible with Invasive Carcinoma of the non-special type (IC NST) (87.5%), histological grade II (52.7%), negative Lymphovascular invasion (LVI) (52.7%), Tumor Size T1 (<2.0 cm) (52%) and Luminal B molecular subtype (36.7%). Regarding sentinel lymph nodes: 103 patients (68.7%) had ECE and 1 positive sentinel lymph node was identified in most cases. There was a statistically significant association between the presence of ECE and of being mixed race (p = 0.03), between ECE and LVI (p = 0.05) and between ECE and a greater number of positive non-sentinel lymph nodes (p < 0.001).
Our study showed that ECE> 2 mm is associated with increased axillary nodal load compared to groups without ECE and ECE ≤ 2 mm in sentinel node biopsy in patients who met the Z0011 criteria.
•The majority of patients had ECE and 1 SLN+.•The presence of ECE was related to mixed race, LVI and greater number of SLN+.•Patient who met Z0011 criteria ECE> 2 mm is associated with high axillary nodal load.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>33930842</pmid><doi>10.1016/j.suronc.2021.101594</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-0890-9430</orcidid></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Biopsy Breast cancer Breast Neoplasms - pathology Breast Neoplasms - surgery Cancer therapies Cross-Sectional Studies Extracapsular extension Extranodal Extension - diagnosis Female Follow-Up Studies Genetics Humans Invasiveness Lymph Node Excision Lymph nodes Lymphatic Metastasis - diagnosis Lymphatic system Medical prognosis Metastases Metastasis Middle Aged Patients Prevalence Prognosis Race Sentinel Lymph Node - pathology Sentinel Lymph Node - surgery Sentinel Lymph Node Biopsy Sentinel lymph nodes Statistical analysis Tumors Womens health |
| title | Prevalence of extracapsular extension in metastatic sentinel lymph nodes in breast cancer |
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