Membrane supply and remodeling during autophagosome biogenesis

The de novo generation of double-membrane autophagosomes is the hallmark of autophagy. The initial membranous precursor cisterna, the phagophore, is very likely generated by the fusion of vesicles and acts as a membrane seed for the subsequent expansion into an autophagosome. This latter step requir...

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Veröffentlicht in:	Current opinion in cell biology 2021-08, Vol.71, p.112-119
Hauptverfasser:	Gómez-Sánchez, Rubén, Tooze, Sharon A., Reggiori, Fulvio
Format:	Artikel
Sprache:	eng
Schlagworte:	ATG proteins Autophagy Isolation membrane Lipid source Lipids Membrane contact site Membrane origin Omegasome Phagophore Vesicular transport
Online-Zugang:	Volltext
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