Medioresinol as a novel PGC-1α activator prevents pyroptosis of endothelial cells in ischemic stroke through PPARα-GOT1 axis

Brain microvascular endothelial cells (BMVECs), as the important structure of blood-brain barrier (BBB), play a vital role in ischemic stroke. Pyroptosis of different cells in the brain may aggravate cerebral ischemic injury, and PGC-1α plays a major role in pyroptosis. However, it is not known whet...

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Veröffentlicht in:	Pharmacological research 2021-07, Vol.169, p.105640-105640, Article 105640
Hauptverfasser:	Wang, Yunjie, Guan, Xin, Gao, Cheng-Long, Ruan, Wenchen, Zhao, Shunyi, Kai, Guoyin, Li, Fei, Pang, Tao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aspartate Aminotransferase, Cytoplasmic - metabolism Chromatin Immunoprecipitation Disease Models, Animal Endothelial cells Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Fluorescent Antibody Technique Gas Chromatography-Mass Spectrometry HEK293 Cells - drug effects Humans Ischemic stroke Ischemic Stroke - drug therapy Lignans - pharmacology Lignans - therapeutic use Male Medioresinol Membrane Potential, Mitochondrial - drug effects Mice Mice, Inbred ICR Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - agonists PGC-1α Phenylalanine PPAR alpha - metabolism PPARα Pyroptosis Pyroptosis - drug effects Rats Rats, Sprague-Dawley
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