Mast cell tryptases in allergic inflammation and immediate hypersensitivity

Dysregulated mast cell-mediated inflammation and/or activation have been linked to a number of human diseases, including asthma, anaphylaxis, chronic spontaneous urticaria, and mast cell activation syndromes. As a major mast cell granule protein, tryptase is a biomarker commonly used in clinical pra...

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Veröffentlicht in:	Current opinion in immunology 2021-10, Vol.72, p.94-106
Hauptverfasser:	Lyons, Jonathan J., Yi, Tangsheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Capillary Permeability - genetics Capillary Permeability - immunology Disease Susceptibility - immunology Enzyme Activation Gene Expression Regulation Genetic Predisposition to Disease Genotype Humans Hypersensitivity - diagnosis Hypersensitivity - etiology Hypersensitivity - metabolism Hypersensitivity, Immediate - diagnosis Hypersensitivity, Immediate - etiology Hypersensitivity, Immediate - metabolism Inflammation - diagnosis Inflammation - etiology Inflammation - metabolism Isoenzymes Mast Cells - immunology Mast Cells - metabolism Mutation Phenotype Structure-Activity Relationship Substrate Specificity Tryptases - genetics Tryptases - metabolism
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