Effects of exercise in patients with connective tissue disease receiving high-dose glucocorticoids: A pilot prospective cohort study
Purpose High doses of glucocorticoids induce skeletal muscle weakness. The aim of this study was to evaluate the effects of exercise therapy on skeletal muscle strength, mass, and exercise capacity in patients with connective tissue disease treated with high doses of glucocorticoids. Methods This pr...
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| Veröffentlicht in: | European journal of applied physiology 2021-08, Vol.121 (8), p.2253-2263 |
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| creator | Nagashima, Masaaki Takahashi, Daiki Mizushima, Takashi Yamauchi, Katsuya |
| description | Purpose
High doses of glucocorticoids induce skeletal muscle weakness. The aim of this study was to evaluate the effects of exercise therapy on skeletal muscle strength, mass, and exercise capacity in patients with connective tissue disease treated with high doses of glucocorticoids.
Methods
This prospective, observational, single-center, cohort study included 35 patients aged ≥ 15 years diagnosed with connective tissue disease who received high-dose glucocorticoids and physical training. Exercise therapy, including moderate aerobic and strength training, was performed five times a week. Knee extension strength, skeletal muscle mass, anaerobic threshold, and peak oxygen consumption were measured at the beginning of exercise therapy and at discharge.
Results
After 6 weeks of aerobic and strength exercises, skeletal muscle mass significantly decreased by 5.5%, right knee extension decreased by 11.6%, and left knee extension decreased by 9.7%. The anaerobic threshold and peak oxygen consumption significantly increased by 13.0% and 9.0%, respectively. The increase in glucocorticoid dose was inversely correlated with changes in knee extension strength.
Conclusion
In patients with connective tissue disease being treated with high-dose glucocorticoids, exercise therapy might attenuate the decrease in skeletal muscle mass and strength and increase the anaerobic threshold and peak oxygen consumption, thus moderating the side effects of high-dose glucocorticoid treatment.
Trial registration
The trial is registered with UMIN (University Hospital Medical Information Network), ID number UMIN000038836. |
| doi_str_mv | 10.1007/s00421-021-04697-2 |
| format | Article |
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High doses of glucocorticoids induce skeletal muscle weakness. The aim of this study was to evaluate the effects of exercise therapy on skeletal muscle strength, mass, and exercise capacity in patients with connective tissue disease treated with high doses of glucocorticoids.
Methods
This prospective, observational, single-center, cohort study included 35 patients aged ≥ 15 years diagnosed with connective tissue disease who received high-dose glucocorticoids and physical training. Exercise therapy, including moderate aerobic and strength training, was performed five times a week. Knee extension strength, skeletal muscle mass, anaerobic threshold, and peak oxygen consumption were measured at the beginning of exercise therapy and at discharge.
Results
After 6 weeks of aerobic and strength exercises, skeletal muscle mass significantly decreased by 5.5%, right knee extension decreased by 11.6%, and left knee extension decreased by 9.7%. The anaerobic threshold and peak oxygen consumption significantly increased by 13.0% and 9.0%, respectively. The increase in glucocorticoid dose was inversely correlated with changes in knee extension strength.
Conclusion
In patients with connective tissue disease being treated with high-dose glucocorticoids, exercise therapy might attenuate the decrease in skeletal muscle mass and strength and increase the anaerobic threshold and peak oxygen consumption, thus moderating the side effects of high-dose glucocorticoid treatment.
Trial registration
The trial is registered with UMIN (University Hospital Medical Information Network), ID number UMIN000038836.</description><identifier>ISSN: 1439-6319</identifier><identifier>EISSN: 1439-6327</identifier><identifier>DOI: 10.1007/s00421-021-04697-2</identifier><identifier>PMID: 33914153</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Anaerobic threshold ; Assessment of cardiovascular function during human activities ; Biomedical and Life Sciences ; Biomedicine ; Cohort analysis ; Connective tissue diseases ; Drug dosages ; Exercise ; Glucocorticoids ; Human Physiology ; Knee ; Life Sciences & Biomedicine ; Muscle strength ; Musculoskeletal system ; Occupational Medicine/Industrial Medicine ; Original Article ; Oxygen consumption ; Patients ; Physical fitness ; Physical training ; Physiology ; Science & Technology ; Skeletal muscle ; Sport Sciences ; Sports Medicine</subject><ispartof>European journal of applied physiology, 2021-08, Vol.121 (8), p.2253-2263</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>5</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000645475700001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c424t-3992ead0e68ab247aad5c5c808a4d5642c41cb0717bc7cabc1a29546c7df2e2b3</citedby><cites>FETCH-LOGICAL-c424t-3992ead0e68ab247aad5c5c808a4d5642c41cb0717bc7cabc1a29546c7df2e2b3</cites><orcidid>0000-0001-5837-3350</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00421-021-04697-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00421-021-04697-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33914153$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nagashima, Masaaki</creatorcontrib><creatorcontrib>Takahashi, Daiki</creatorcontrib><creatorcontrib>Mizushima, Takashi</creatorcontrib><creatorcontrib>Yamauchi, Katsuya</creatorcontrib><title>Effects of exercise in patients with connective tissue disease receiving high-dose glucocorticoids: A pilot prospective cohort study</title><title>European journal of applied physiology</title><addtitle>Eur J Appl Physiol</addtitle><addtitle>EUR J APPL PHYSIOL</addtitle><addtitle>Eur J Appl Physiol</addtitle><description>Purpose
High doses of glucocorticoids induce skeletal muscle weakness. The aim of this study was to evaluate the effects of exercise therapy on skeletal muscle strength, mass, and exercise capacity in patients with connective tissue disease treated with high doses of glucocorticoids.
Methods
This prospective, observational, single-center, cohort study included 35 patients aged ≥ 15 years diagnosed with connective tissue disease who received high-dose glucocorticoids and physical training. Exercise therapy, including moderate aerobic and strength training, was performed five times a week. Knee extension strength, skeletal muscle mass, anaerobic threshold, and peak oxygen consumption were measured at the beginning of exercise therapy and at discharge.
Results
After 6 weeks of aerobic and strength exercises, skeletal muscle mass significantly decreased by 5.5%, right knee extension decreased by 11.6%, and left knee extension decreased by 9.7%. The anaerobic threshold and peak oxygen consumption significantly increased by 13.0% and 9.0%, respectively. The increase in glucocorticoid dose was inversely correlated with changes in knee extension strength.
Conclusion
In patients with connective tissue disease being treated with high-dose glucocorticoids, exercise therapy might attenuate the decrease in skeletal muscle mass and strength and increase the anaerobic threshold and peak oxygen consumption, thus moderating the side effects of high-dose glucocorticoid treatment.
Trial registration
The trial is registered with UMIN (University Hospital Medical Information Network), ID number UMIN000038836.</description><subject>Anaerobic threshold</subject><subject>Assessment of cardiovascular function during human activities</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cohort analysis</subject><subject>Connective tissue diseases</subject><subject>Drug dosages</subject><subject>Exercise</subject><subject>Glucocorticoids</subject><subject>Human Physiology</subject><subject>Knee</subject><subject>Life Sciences & Biomedicine</subject><subject>Muscle strength</subject><subject>Musculoskeletal system</subject><subject>Occupational Medicine/Industrial Medicine</subject><subject>Original Article</subject><subject>Oxygen consumption</subject><subject>Patients</subject><subject>Physical fitness</subject><subject>Physical training</subject><subject>Physiology</subject><subject>Science & Technology</subject><subject>Skeletal muscle</subject><subject>Sport Sciences</subject><subject>Sports Medicine</subject><issn>1439-6319</issn><issn>1439-6327</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkU2LFDEQhhtR3HX1D3iQgBdBWpN0utPxtgzrByx40XOTrlTPZOlJ2k56P-7-cGvocQQP4qFIKJ63qOIpipeCvxOc6_eJcyVFyQ-lGqNL-ag4F6oyZVNJ_fj0F-aseJbSDee8laJ9WpxVlRFK1NV58fNqGBByYnFgeI8z-ITMBzbZ7DFQ_87nHYMYAlH-Fln2KS3IHHGW0BkB_a0PW7bz213pIvW24wIR4pw9RO_SB3bJJj_GzKY5puk4B-KOCJby4h6eF08GOyZ8cXwviu8fr75tPpfXXz992Vxel6CkymVljETrODat7aXS1roaamh5a5WrGyVBCei5FroHDbYHYaWpVQPaDRJlX10Ub9a5tMiPBVPu9j4BjqMNGJfUyVqYlptGGEJf_4XexGUOtB1Rqm2N4ZUgSq4U0GVpxqGbZr-380MneHdw1K2OOn6og6NOUujVcfTS79GdIr-lENCuwB32cUhAIgBPGFlsVK10renHxcZnUhXDJi4hU_Tt_0eJrlY6ERG2OP858h_7_wJAn7_S</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Nagashima, Masaaki</creator><creator>Takahashi, Daiki</creator><creator>Mizushima, Takashi</creator><creator>Yamauchi, Katsuya</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature</general><general>Springer Nature B.V</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5837-3350</orcidid></search><sort><creationdate>20210801</creationdate><title>Effects of exercise in patients with connective tissue disease receiving high-dose glucocorticoids: A pilot prospective cohort study</title><author>Nagashima, Masaaki ; Takahashi, Daiki ; Mizushima, Takashi ; Yamauchi, Katsuya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-3992ead0e68ab247aad5c5c808a4d5642c41cb0717bc7cabc1a29546c7df2e2b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Anaerobic threshold</topic><topic>Assessment of cardiovascular function during human activities</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cohort analysis</topic><topic>Connective tissue diseases</topic><topic>Drug dosages</topic><topic>Exercise</topic><topic>Glucocorticoids</topic><topic>Human Physiology</topic><topic>Knee</topic><topic>Life Sciences & Biomedicine</topic><topic>Muscle strength</topic><topic>Musculoskeletal system</topic><topic>Occupational Medicine/Industrial Medicine</topic><topic>Original Article</topic><topic>Oxygen consumption</topic><topic>Patients</topic><topic>Physical fitness</topic><topic>Physical training</topic><topic>Physiology</topic><topic>Science & Technology</topic><topic>Skeletal muscle</topic><topic>Sport Sciences</topic><topic>Sports Medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nagashima, Masaaki</creatorcontrib><creatorcontrib>Takahashi, Daiki</creatorcontrib><creatorcontrib>Mizushima, Takashi</creatorcontrib><creatorcontrib>Yamauchi, Katsuya</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of applied physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nagashima, Masaaki</au><au>Takahashi, Daiki</au><au>Mizushima, Takashi</au><au>Yamauchi, Katsuya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of exercise in patients with connective tissue disease receiving high-dose glucocorticoids: A pilot prospective cohort study</atitle><jtitle>European journal of applied physiology</jtitle><stitle>Eur J Appl Physiol</stitle><stitle>EUR J APPL PHYSIOL</stitle><addtitle>Eur J Appl Physiol</addtitle><date>2021-08-01</date><risdate>2021</risdate><volume>121</volume><issue>8</issue><spage>2253</spage><epage>2263</epage><pages>2253-2263</pages><issn>1439-6319</issn><eissn>1439-6327</eissn><abstract>Purpose
High doses of glucocorticoids induce skeletal muscle weakness. The aim of this study was to evaluate the effects of exercise therapy on skeletal muscle strength, mass, and exercise capacity in patients with connective tissue disease treated with high doses of glucocorticoids.
Methods
This prospective, observational, single-center, cohort study included 35 patients aged ≥ 15 years diagnosed with connective tissue disease who received high-dose glucocorticoids and physical training. Exercise therapy, including moderate aerobic and strength training, was performed five times a week. Knee extension strength, skeletal muscle mass, anaerobic threshold, and peak oxygen consumption were measured at the beginning of exercise therapy and at discharge.
Results
After 6 weeks of aerobic and strength exercises, skeletal muscle mass significantly decreased by 5.5%, right knee extension decreased by 11.6%, and left knee extension decreased by 9.7%. The anaerobic threshold and peak oxygen consumption significantly increased by 13.0% and 9.0%, respectively. The increase in glucocorticoid dose was inversely correlated with changes in knee extension strength.
Conclusion
In patients with connective tissue disease being treated with high-dose glucocorticoids, exercise therapy might attenuate the decrease in skeletal muscle mass and strength and increase the anaerobic threshold and peak oxygen consumption, thus moderating the side effects of high-dose glucocorticoid treatment.
Trial registration
The trial is registered with UMIN (University Hospital Medical Information Network), ID number UMIN000038836.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33914153</pmid><doi>10.1007/s00421-021-04697-2</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-5837-3350</orcidid></addata></record> |
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| subjects | Anaerobic threshold Assessment of cardiovascular function during human activities Biomedical and Life Sciences Biomedicine Cohort analysis Connective tissue diseases Drug dosages Exercise Glucocorticoids Human Physiology Knee Life Sciences & Biomedicine Muscle strength Musculoskeletal system Occupational Medicine/Industrial Medicine Original Article Oxygen consumption Patients Physical fitness Physical training Physiology Science & Technology Skeletal muscle Sport Sciences Sports Medicine |
| title | Effects of exercise in patients with connective tissue disease receiving high-dose glucocorticoids: A pilot prospective cohort study |
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