CF3SO3H-enabled cascade ring-opening/dearomatization of indole derivatives to polycyclic heterocycles

A novel dearomatization process to produce fused polycyclic indolines via a CF3SO3H-mediated cascade ring-opening of a β-lactam and hydroaminative cyclization is demonstrated. It provides a new strategy for the synthesis of important polycyclic indoline-2-amine derivatives in moderate to excellent y...

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Veröffentlicht in:	Organic & biomolecular chemistry 2021-05, Vol.19 (20), p.4469-4473
Hauptverfasser:	Yao, Zhengdong, Feng, Huangdi, Xi, Hui, Xi, Chuanjun, Liu, Weiping
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides Functional groups Heterocyclic compounds Indoles Ring opening Triflic acid β-Lactam antibiotics
Online-Zugang:	Volltext
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